2IDL,1S12,2IDL,2G0J,2G0J,2G0I,4PEO,4PEO


Conserved Protein Domain Family
Prp-like
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cd16332: Prp-like 
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ribosomal-processing cysteine protease Prp and similar proteins
This model represents a family of cysteine proteases that include members found to cleave the N-terminus extension of ribosomal subunit L27 in eubacteria. Proteins in this family are distinguished by a pair of invariant histidine and cysteine residues with conserved spacing that form the classic catalytic dyad of a cysteine protease. Dependence of Staphylococcus aureus on L27 cleavage by Prp makes the enzyme a target for antibiotic development.
Links
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Statistics
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PSSM-Id: 381747
Aligned: 607 rows
Threshold Bit Score: 54.7919
Created: 31-Jul-2019
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic site [active site], 2 residue positions
Conserved feature residue pattern:H CClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                             #           #                                              
2IDL_A         4 MIQAVFERaedgelRSAEITGHAesgeyglDVVCASVSTLAINFINSIEkfagyepILELNedegGYLMVEIPkdlp--- 80  Streptococcus p...
WP_016525665   1 MIRAELTRaqngelHSCIIRGHAgfapkgkDIVCAAVSILARTALDVLHehg--glELKTDsaerGMLSFTVRrkarssp 78  Treponema malto...
WP_013758907   1 MTVVYLSRsrngqfRSCRAEGHSgyapsgsDIVCAAVTVLLRTTLQVLSesf--gsAVKTDitsrGNLAFRVDdfag--- 75  Treponema brenn...
WP_021687267   1 MIRVVLEClsdgalLSCKAQGHSmfapagqDIVCAAASVLLRTALSVLKdts--gfIIKTDkpkrGMLSFYVDcmqkdd- 77  Treponema lecit...
WP_021329152   1 MISVQLARakdgslASCRALGHArfaekgnDIVCSAVTVLLRTTMQALSete--gvFVRLDapdrGALDFDVSaesap-- 76  Treponema socra...
EIC03061       1 MTEVTLSCgrngavKTCEANGHAcssrkgsDVVCAAVSALLKTAMLVLShte--nvAFDADvsarGKLAFRADmqenlgg 78  Treponema sacch...
WP_013701109   1 MTEVLLVCgkdgalKSLKAFGHAsfaekgkDIVCAAESIILGTSVELLQstk--glVFNADtstrGFLEFRVEksav--- 75  Treponema succi...
WP_013968248   1 MVAVDVVLdpagliKSCKVSGHAgagprngDVVCAAVSVLSRTALRTLTktd--gvTARGKapqrGELFMEIDyte---- 74  Treponema caldaria
WP_015712081   1 MIQAEVVLdgg-llKSCRVQGHAgsgpkgsDIVCAAVSVLSRTVLRTLSrre--giTVRSEaperGILLLEAEgig---- 73  Treponema azoto...
WP_015706840   1 MIHIGAVLdgtgllRSCTVKGHAgagpkgdDIVCAAVSVLTRTALRILSeke--giMVQGEaperGLVRMEIDytg---- 74  Treponema primitia

Feature 1                                                  
2IDL_A        81 --------shqrEMTQLFFESFFLGMANLSENYs--eFVQTR 112 Streptococcus pneumoniae TIGR4
WP_016525665  79 dpqstrndgelsALLSYTADFLQKGFDSLQKEYp--aYVSAE 118 Treponema maltophilum
WP_013758907  76 ---------gksCRLIYAADFLRSGLTALQNEYp--dCVTMR 106 Treponema brennaborense
WP_021687267  78 -------avghrEILIYTAVFLQKGLSALQAEYp--sHLSLQ 110 Treponema lecithinolyticum
WP_021329152  77 --------pesrCALVYAGRFLEAGLASLAREYp--hNVELK 108 Treponema socranskii
EIC03061      79 -----pdkieaeSRLRCVADFIRSGVSSVSDEYp--gYVLLR 113 Treponema saccharophilum DSM 2985
WP_013701109  76 ---------savERLKCIGDFIRFAFIKLSAEYp--dNVRFQ 106 Treponema succinifaciens
WP_013968248  75 ---------askDQVAGITAFLLEGMLSVSEEFpehcCVRIQ 107 Treponema caldaria
WP_015712081  74 ---------gsrEFLAAAGAFLCEGLLSVAEEYp--eFCQVT 104 Treponema azotonutricium
WP_015706840  75 ---------egrEFLSAAGTFLLEGLKSISEEFp--eYCTMN 105 Treponema primitia

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