Conserved Protein Domain Family
UPAR_LY6_2

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pfam16975: UPAR_LY6_2 
Ly6/PLAUR domain-containing protein 6, Lypd6
UPAR_LY6_2 is a family of higher eukaryotic proteins expressed in neurons. It modulates nicotinic acetylcholine receptors by selectively increasing Ca2+-influx through this ion channel. The family carries an LU protein domain - about 80 amino acids long characterized by a conserved pattern of 10 cysteine residues. The family is a positive feedback regulator of Wnt/beta-catenin signalling, eg for patterning of the mesoderm and neuroectoderm in zebrafish gastrulation, where Lypd6 is GPI-anchored to the plasma-membrane and interacts with the Wnt receptor Frizzled8 and the co-receptor Lrp6.
Statistics
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PSSM-Id: 435685
Aligned: 15 rows
Threshold Bit Score: 157.121
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006003854  40 TPFLYSFKCFTCDSAPDNYNCNRWAEDKWCPQDTDYCLTIHHFTSHGKSKSVTKRCAKKEECHFVGCHhhHHRDFGHTEC 119
AFJ71300      40 TTPYPGGFKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGC--RDSEHEGHKV 117
AAI54707      40 TTPYPGGFKCFTCEKAADNYDCNRWAPDIFCPRETRYCYTQHIMNATGESVSVTKRCAALEHCLNSGC--RDSINKDQKV 117
Q66IA6        40 TTPYPGGFKCFTCEDAPDNYECNRWAPDLYCPRESRYCYTHHKMSWDGNTVSVTKRCVPLEDCLQTGC--SDIDHEGNRV 117 zebrafish
XP_008116044  40 TTPYPGGFKCFTCEQAVDNYECNQWAPDIYCPRVTRYCYTQHTLEANGKSVSVTKRCVPLEDCLATGC--IDLQHKGLRV 117
XP_013053574  40 TTPFPHGFKCFTCEKAADNYECNRWAPDVYCPRGTRYCFSQHMMKVTGESVSVTKRCVPLEDCLSTGC--TYVKHEEYKV 117
XP_006003864  40 TTPYPGGFKCFTCENASDNYECNRWAPDVYCPRGTKYCYTQHRMDSNGMSISVTKQCMSLEGCMSTGC--SETKLEGHKV 117
XP_003440959  40 TTPYPGGFKCFTCQDAVDNYDCNRWAPDVYCPKDTKYCSTLHMMDRSGESVSVTKRCATMEECLFTGC--ADVADTGYQV 117
XP_422156     39 PTPFPNSFKCFTCDNAVDNYNCNRWAEDRWCPESTQYCLTVHLFTDHGKSTSVTKKCATGDECHFVGC--HHHRESGHTE 116
XP_016155453  39 PTPFPNSFKCFTCDNAVDNYNCNRWAEDRWCPASTRYCLTAHLFTARGQSTSVTKKCATGEECHLVGC--HRHGDSGHTE 116
XP_006003854 120 TSCCEGMICNVDVPTNHTNAVFAVIQSG 147
AFJ71300     118 CTSCCEGNICNLPLPRNETDATFATTSP 145
AAI54707     118 CTSCCEGNICNLPLPRNETDAIFATTSP 145
Q66IA6       118 CTACCEGNICNLPLPRNETDAIFSTTSP 145 zebrafish
XP_008116044 118 CTSCCEGNICNLPLPRNASDAIFATTTP 145
XP_013053574 118 CTSCCEGSICNLPLPRNTTDAVFTTLSP 145
XP_006003864 118 CTSCCEGNICNLPLPWNASDAIFATISP 145
XP_003440959 118 CSSCCEGNICNVLVPRNDSSAIFSSISP 145
XP_422156    117 CVSCCEGMICNVEIPTNHTNAVFAVLHA 144
XP_016155453 117 RVSCCEGMICNVQIPTNATNAVLAVLQA 144
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