Conserved Protein Domain Family
TMEM127

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pfam20517: TMEM127 
Transmembrane protein 127
TMEM127 modulates mTOR function in the endolysosome. Its interaction with early endosomal GTPase Rab5 to inhibit mTOR signalling seems to be related with its tumour-suppressing properties.
Statistics
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PSSM-Id: 466666
Aligned: 15 rows
Threshold Bit Score: 117.36
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008478170 104 CLSNDVIRLMQVIIFLCFLAVFYSLFGFFLDLFGPKQKLFKILRRNAVPSILCVLTIMCIVAVSYMVTEAMQANAIPEDS 183
PAA59744     160 CVNNDVVITVRTVLTLLLVAVAFTIMQLLLDLFAPNARLLKVVQFNATGSITTSLVCVTACGLAYWAAELIRGVQEATQL 239
PIK61926     104 CFDDQSTPIMRSIVAMLFLSVTTTLFAFTLDTLGPSGKILKGMRRYAVGNILTVIICVITCLLSFWAAIVLEDMLRKDPI 183
PVD30802     159 CITDRGVLLFKAVIAFTFMAIICSLCSFLIDLIGPSQRFFKLIRRSSIFNVITVILCVVVTLFMYWITVVVLTLQQEV-- 236
CDW55412     103 CVTPEIVDIFHALIGVIFITLMLAFSNVIVSACELNRGPFRWIRTNSVFNVFLVFFCVFTIGISYWVSQLIENFQRS-TT 181
KOB71733      61 HMMQGVYQTTIVLILLCFMVLLCSSVGTLINLTSLNSRAIRILRRNAVPSIMCVFWVIAIVGVCYYATVELGNG-----S 135
OWR53939      98 CITTEIITLMRILILLCFMVLLSSCIGVLINLINHNSKALKMLRRNAVPSIMCVFWVIAIVGVCYYTTV-VLGNANN--- 173
PNF23554     102 CVTPEIASLMRVIIILCFMAMICSLVGFFLDIVGPTKKAMKVIQRNSIPSIFTVLWVIAIIGVCYDVTKLIE-------- 173
XP_018325690  78 CINNTVVNLMRIILLLCFMAIIFSLGGFILDISQLQNKVLIYIQQYALCSSFTVFWVMAIVSFCYYTTLVIQ--ESLDNL 155
KRT80650      78 CIDGVIVNLMRVIILLCFMGIIFSLYGFFLHIVGPKSSIYNFIRKHALASTCTVIWILSIISTCYYIAI--LLEDSLAVH 155
XP_008478170 184 sPKHYILQVTYDNGYYLITIAGAFAIVTTACNLL 217
PAA59744     240 -RPDSHVTVSLCSGYYLVGAAGLLSILAAAFNCL 272
PIK61926     184 -APTSRTVVTFDTGYFLMVMSGALSILISATNLL 216
PVD30802     237 --ESTEVQVSFDVSFYLITAAGVTSVVAVAFSCL 268
CDW55412     182 -DAPELVHVSFGEGFYLIVAAACFFICAFVSNIV 214
KOB71733     136 -GDSNAIQVDYEYGFYTITGAGALALLASAANLW 168
OWR53939     174 -SDPNTIQVDYEYGFYTITGAGALALVASAANLW 206
PNF23554     174 -VSGIQVYYEY--GCYTITAAGAVAVCATACNLL 204
XP_018325690 156 -YPKLETSVTYGLGFYLVAITGGVALLGNLCSLI 188
KRT80650     156 -YPKINATVSYGYGFYVITAAGSVSVTGTFWTLI 188
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