Conserved Protein Domain Family
Rep_trans

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pfam02486: Rep_trans 
Replication initiation factor
Plasmid replication is initiated by the replication initiation factor (REP). This family represents a probable topoisomerase that makes a sequence-specific single-stranded nick in the plasmid DNA at the origin of replication. Human proteins also belong to this family, including myelin transcription factor 2 and cerebrin-50.
Statistics
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PSSM-Id: 426796
Aligned: 34 rows
Threshold Bit Score: 129.765
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8DX40        188 MNVTRFDIAIDELylgkdreNEQF-HLSDMISKYyRHELDFESLRTWNYIGGGSLNFSDMeeie-qnrQGISLYFGSRQS 265 Streptococcus ...
Q9PCC2        171 ARITRCDVAYDDY-------QGELgTVRHHEAQA-RENLAPSGGCLLFASG-GTPPRTRFlddh-gggSGCTLYVGQKGH 240 Xylella fastid...
CBA16047      142 ARVTRCDIAYDDY-------DGVLgTVRDHEAQA-RANMSDTGGCLLFGSGPGAPPKTRFmddh-gngDGSTLYVGGKGH 212
jgi:M301_2558 190 AKITRWDGAVDDF-------IGLH-TVDSAVELY-IAGAFNAGGKRPSCDQRGNWLMPDG--------NGRTFYIGKREN 252
Q5F7M4        197 PKITRIDVAHDFF-------NGEY-TPDQAMLDH-DNGHYDVHNMRPKSECRGTAWRNEDg-------SGKTFYIGKRGN 260 Neisseria gono...
Q9JYD6        142 PRITRVDLALDFF-------DGEY-TPEQALLDH-DNGFFDNSNMRPKSEMVGTAWRREDg-------SGKTFYVGRKKN 205 Neisseria meni...
WP_011804175  144 PTITRVDLAKDFF-------EGEV-TIEEVVHLY-KHDEFSYRNRKPKYTTHGCWSLGHDadgmpmlgHSRTFQVGKRES 214 Acidovorax sp....
jgi:Daci_2103 143 PTITRIDAAKDFF-------AGEV-TIEEVVGLY-KDHKFSYRKRMPKYTTHGAWELGSTvddiplhgHSRTFQVGKRES 213
jgi:Aave_2407 199 GWLTRIDLALDFF-------DGLNgGMERVKADY-EAGLCDVGGRRLKCNMVGDWCGG----------KARSFYVGTKEV 260
CDA82212       98 LKITRLDVAFDDH-------TGVL-DIDQIVEDT-RRKHYVSRSDYWETVLSS---------------KGSTVQIGSPQS 153
Q8DX40        266 EMyFNFYEKRYEIAKQEGItveealeifELWNRYEIRLSQSKANAAVDEFI----SGVPIGEISRGLIVSKIDV-YDGKN 340 Streptococcus ...
Q9PCC2        241 KQ-LCIYDKGKQLGSPD-----------SPWVRYEVRFYGKHAVIPLDILVdsfrYLRGSYGYLDSLLSRVVSS------ 302 Xylella fastid...
CBA16047      213 KQ-LCIYEKGKQLGVCE-----------SPWVRYEARLYGKHAELPLEMLThpmrYLRGSYAYMDRLLATVGQG------ 274
jgi:M301_2558 253 GKmMRIYEKGMQLGEKW-----------SPWVRWEIELHNVDREIPWDVLLepgkYVAGAYPKATGWIQN---------- 311
Q5F7M4        261 SKfTRVYEKGRQLGDVD-----------SPWVRFE-----GDIEIPLDVLLysgsYLGGAYPICKEIFKT---------- 314 Neisseria gono...
Q9JYD6        206 SRfVRVYEKGRQLGDKE-----------SKWVRFEIQFNHGDMEIPLDILInqgsYFSGAFPICQKFKNMP--------- 265 Neisseria meni...
WP_011804175  215 GKlARFYEKGHQYSMMD-----------SRWLRAEAELRNVNRIIPWDTLIstadYFAGAYPALQLVANTD--------- 274 Acidovorax sp....
jgi:Daci_2103 214 GKlARFYEKDHQYGNFA-----------GSWLRAELELRNAGRVIPWDAVInaaeYYAGGYEALKLLCDRD--------- 273
jgi:Aave_2407 261 GKqTNVYEKGHQLFGDADT---------SAWIRAELRWGNKARFLPTDMLRrpadFFHGASDWHASLLREAEAI------ 325
CDA82212      154 KVlVRIYDKAAERHCEPG----------THWVRVEMQLRDDRAIQYSKIPL-------SIGEAFSGVLLNYLRYvIPDDT 216
Q8DX40        341 E--YGSFQADRKWQLMFG-GVEPLKF-VTKPEAYSIERTLRWLSDSVSPSLAMIREYDMIVDGDYLQTIL 406 Streptococcus agalactiae...
Q9PCC2        303 -------------------VSSRIHC-VVKHVEASGVAMVRWLRRQAGPAISLLRQSLGESFNDFIAQYI 352 Xylella fastidiosa
CBA16047      275 -------------------VATAVKI-SKRTVEATAEAMVRWAHRQVGPTLHCLREALGDQFGDFVVNhl 324
jgi:M301_2558 312 -------------------EMSRVRT-MQNTTRISYDHMTACTSLSFGKHLNVMLEVEG-SAEKVLQKLI 360
Q5F7M4        315 -------------------EAKRMEV-KVKNVNLIFDVKLFHARNQVGKMVNFLRDIGW-DDSRIVDELV 363 Neisseria gonorrhoeae FA...
Q9JYD6        266 -------------------NPERFDY-RKKVANLTFQHKLRYAKNAVGKLINFMFDMGF--DSDEIVRYL 313 Neisseria meningitidis s...
WP_011804175  275 -------------------TATRIPT-GKKVAEASAQRVVNWLQRVVAPTLVQVSKVMP--NEDWliglv 322 Acidovorax sp. JS42
jgi:Daci_2103 274 -------------------AGTVIPT-SVKAGEASADKFVRWIVRTVAPSLAQITKIMP--DEDWLHGiv 321
jgi:Aave_2407 326 --------------SFPEtVSCEAKR-QIETVEGEAVRNVRWLREVAAPSLALAFQHLD------FEHFL 374
CDA82212      217 DsnKWRWPMTDYWLDMLE-VLTPIKIyTAPGMDYNIDRCREYVVNQAGNAIDALLQIYG------IHEFQ 279
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