Conserved Protein Domain Family
Arl9_Arfrp2_like
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cd04162: Arl9_Arfrp2_like 
Arf-like 9 (Arl9)/Arfrp2-like GTPase
Arl9/Arfrp2-like subfamily. Arl9 (Arf-like 9) was first identified as part of the Human Cancer Genome Project. It maps to chromosome 4q12 and is sometimes referred to as Arfrp2 (Arf-related protein 2). This is a novel subfamily identified in human cancers that is uncharacterized to date.
Links
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Statistics
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PSSM-Id: 133362
Aligned: 8 rows
Threshold Bit Score: 250.443
Created: 26-Sep-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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  next features
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Based on alignment to Arl2
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #######               ##                     #                           
NP_001014943  34 DLVCIGLTGSGKTSLLSKLCSe-SPDSVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASS 112 cow
NP_061960     34 DLVCIGLTGSGKTSLLSKLCSe-SPDNVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASS 112 human
AAH75239      41 DIVCIGLTGSGKTSLLTHLCNe-SQENIVPTTGFSIKAIPFQSAIMNVKELGGATNIRKYWSRYYQGSQGVIFVLDSASS 119 African clawed ...
AAH59361      79 EVLVLGLDGAGKSTFLRVLSGkpPLEGHIPTWGFNSVRLPTKDFEVDLLEIGGSQNLRFYWKEFVSEVDVLVFVVDSADR 158 human
NP_775935     79 EVLVLGLDGAGKSTFLRVLSGkpPLEGHIPTWGFNSVRLPTKDFEVDLLEIGGSQNLRFYWKEFVSEVDVLVFVVDSADR 158 human
AAS07576      20 QILVLGLDGAGKTSVLHSLASnrVQHSVAPTQGFHAVCINTEDSQMEFLEIGGSKPFRSYWEMYLSKGLLLIFVVDSADH 99  human
DAA02254      52 QILVLGLDGAGKSSIIHALSTdtTRSSSAPTHGFNSAQILHQGLRIELLEVGGSHNLRTYWKQYLKNAHIMVFVVDSTDS 131 African clawed ...
NP_001016174  95 QILVLGLDGSGKTSVLNSIVTnrGNHSTVPTEGVHAVCITNGNSKMEFLEVGGSEQLRQFWERYLDRALALIYVVDSSDH 174 western clawed ...

Feature 1                                     ## #                                      ###      
NP_001014943 113 edDLETARNELHSALqhpqlctLPFLILANHQDKPaar--svqEVKKYFelep------largKRWILQPCSLDd----- 179 cow
NP_061960    113 edDLEAARNELHSALqhpqlctLPFLILANHQDKPaar--svqEIKKYFelep------largKRWILQPCSLDd----- 179 human
AAH75239     120 edDLETARNELHSALqhpqlctLPFLILANHQDKPaar--svqEIKKYFelep------largKRWILQPTSVDn----- 186 African clawed ...
AAH59361     159 l-RLPWARQELHKLLdkd--pdLPVVVVANKQVRAvrgqlgpgDIHSEMleqgqgalpgpmawRGWLRCCPHLFylcp-- 233 human
NP_775935    159 l-RLPWARQELHKLLdkd--pdLPVVVVANKQDLSeam--smgELQRELglqa------idnqREVFLLAASIApa---- 223 human
AAS07576     100 s-RLPEAKKYLHQLIaan--pvLPLVVFANKQDLEaay--hitDIHEALalse------vgndRKMFLFGTYLTkngsei 168 human
DAA02254     132 r-RLHLARQELHQLLhee--pdLPLMVLANKQDRTtal--clpEIHSELslhr------itseREVTLLGTSAIsdgaah 200 African clawed ...
NP_001016174 175 s-RLPLAKMHLHQLIqhs--ssLPLVVLANKQDLEnay--hitDIHDALalse------icekRKLYLIGTHVAtdgsel 243 western clawed ...

Feature 1                         
NP_001014943 180 ---mEALKDSFSQLINL 193 cow
NP_061960    180 ---mDALKDSFSQLINL 193 human
AAH75239     187 ---mEAVKDSFSMLLNL 200 African clawed frog
AAH59361     234 vlipASVFLPLCLPIIS 250 human
NP_775935    224 ---gPTFEEPGTVHIWK 237 human
AAS07576     169 pstmQDAKDLIAQLAAD 185 human
DAA02254     201 strlQTVKTLLEERLQS 217 African clawed frog
NP_001016174 244 pssiEDTRELLAQLLLE 260 western clawed frog

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