5DDT,1VGT,2XWL


Conserved Protein Domain Family
IspD

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COG1211: IspD 
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [Lipid transport and metabolism]
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Statistics
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PSSM-Id: 440824
Aligned: 948 rows
Threshold Bit Score: 75.9367
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5DDT_A         6 VIPAAGQGKRM------KAGR-----NKLFIELKGDPVIIHTLRVFDSHRQCDKIILVINEQERe----HFQ-QLLSdyp 69 
WP_015787781   7 LVPLGIEDVPE------T--------SGALARVRGATLLEHTVRRLIDSGHVDRVVVAGPHATRs----ACA-TALRgf- 66 
WP_105187231  12 VIVAAGRGVRF------GGPI-----PKPVTTLAGKAVVAMSVEAMAAGGCTHAIVVI-PRNGEh----HFQ-PVLAa-- 72 
WP_052809173  25 IVVAAGSGVRL------GNSSagghgPKALRKLSGVPLLRHSIDRLVAGG-VDRVVVVSRPEFRe----QMR-ATLAg-- 90 
WP_091803061   3 LVPLGNRD-RH------H--------SGALTRFRGEPLLSHAVRGLLRSGCVDRVVVAGPPHNVa----AYS-AALAlv- 61 
WP_011096372   6 LLLAAGVGSRL------SSSL-----PKAFVSVGGLDLIQWCLKNLGQLRTALEVVVTVPKGFVe----LCErNVLQslg 70 
WP_011736621  11 IVLAGDRGPDDpvasasG--Vg----CKALVPVAGRPMVLRVLDALDASPIIGPRILCGCSSRLlgssaELD-GLVA--- 80 
WP_015069579   9 VVVAGGLGSRF------GGPV-----PKQVRSLTGKAVVAVAVESLAAGGCTEAVVVV-KDGMHn----HFK-MALAa-- 69 
YP_003154369  16 ALAPPAPGLSR------GAAS-----P-CLEPLGGSRLIDRLLGTLR-GVGLPAPLLVTGEAAAp----QLR-AALGw-- 75 
WP_002521161  12 VVVAAGLGTRF------GGPV-----PKQVTSLTGKAVVAVAVESLAAGG-CDEAVVVVKEGMHn----HLQ-LALAa-- 72 
5DDT_A        70 fQTSIELVAGGDERQHSVYKGLKAvKQ-----E-KIVLVHDGARPFIKHEQIDELIAEAEQ-T--GAAILAVPVKDTIKR 140
WP_015787781  67 dDERVSLVPGGQDHQESVRCAVHStAAa----SgDVVLVHEPTRPFTPPETIGAVVAAVRDgA--TAAVPVEPMTDTVKV 140
WP_105187231  73 sPIPVTLVEGDETRQASVRQGIAAiRMkpelkGaHVVLVHDAVRPLVPATVVARVIGTIRGgA--VAVAPAIPVADSIRE 150
WP_052809173  91 iDVPITFTDGGATRTDSVRNGLRVlEG-----VpPVILVHDAARPLVPAEVVSRVIAAVRGgS--STVIPVISLIDSVRA 163
WP_091803061  62 nDAEVKVLAGGGDRIESMRSALTAsSPe----PtDLVLVHDASRPFTPTATFTAVVSELKAgA--VAAVPVEPVTDTIKI 135
WP_011096372  71 tLEKIKIVTGGATRQDSVGLGIRYfSA-----RiTKLLVHDVARAFTPPEIYLSVIKQLET-S--KAVIPVIAIVDSIKK 142
WP_011736621  81 -DGRVSWVENESSPSLSARAALASvPA-----D-QPALVTTADHALLTPPMVDHFCGRAAE-SgcDVVAG-LARADMVMA 151
WP_015069579  70 sPIPVRFVTGGATRQESVRNGLRAiAEsprlsKaGKVLIHDAVRPLVPAYVVKDVIEALGAgA--EAVTPSVPVIDTIRC 147
YP_003154369  76 -ELPVLAVPGERGQ--ALRAVLEA--T-----DeQLLLLHDAERALTPAQTIRDVLSALREdV--DAVVPVTALTDSVKE 143
WP_002521161  73 sPIPVHFVTGGNTRQESVRNGLRFiAQhhrlsDaTTVLIHDAVRPLVPAYVVENVIAAVENgA--VAVTPVVDVVDTIRQ 150
5DDT_A       141 V-QDLQ---V---------SETI--------ERSSLWAVQTPQAFRLSLLMKAHAEAERK--------------G----- 180
WP_015787781 141 VdTTGV---V---------RRTS--------DRDRLRRTQSPRGFTAEFLRRA--------------------------- 173
WP_105187231 151 EtDDGR---L----------VIV--------DRERLRAVQTPQGFDLDVLEASHDYADEQ--------------Q----- 190
WP_052809173 164 VePHG--------------SRVV--------DRSGLRAVQTPQGFDGATLIDAYDHLPAD-------------------- 201
WP_091803061 136 VdSDDV---I---------RGTR--------DRTLLRSIQAPQGFRAATLRGT--------------------------- 168
WP_011096372 143 VnMQDAyreVargpgepfhTKSVlh-----lDRREFFSAQTPQGFDRALLEAAHERSVAS--------------N----- 198
WP_011736621 152 AfPEGR--------------RTItrladggyCGCNLFAFLTPRARNAAIFWRRVEEQRKHplki------vrtlGllsvl 211
WP_015069579 148 VdSE-T---A---------SHVV--------DRSTLRAVQTPQGFDRQVITECHDRLAAD--------------G----- 187
YP_003154369 144 VrPDG----L----------LNI--------DRSTLAGLQSPRLLRRELLESVLSATASAsprpsapesgrvptG----- 196
WP_002521161 151 VdGD-----T---------SSVV--------DRSTLRAVQTPQGFKRDIITECHEQLSIE--------------G----- 189
5DDT_A       181 ------F--L------------GTD-DASLV-EQMeGGSVRVVEGSYTNIKLTTPDDLTSAE-A----I-M-E---S-E- 226
WP_015787781 174 ------------------------D-ITKAL-AFV-DLAVRTVPGHPHGMRVSTAFERTVAE-S----L-F-AewvG-E- 217
WP_105187231 191 ------I--A------------CTD-DISVC-EAA-GHPVRLVKGAMTSLKITSATDLDLAH-A----F-L-K---L-R- 235
WP_052809173 202 ------T--L------------FTD-DASVC-EAQ-GSEVALVEGSVLSMKITRPHDFLFAE-A----L-L-Q---A-G- 246
WP_091803061 169 ------------------------N-TGDPL-TEL-GAKVRTVAGHPHGMRLVSAFDLAVIE-A----L-L-A---A-E- 209
WP_011096372 199 ------E--Q------------FAD-DSVMV-AQI-EKDITLINGHEASFKVTNPCDLQRAE-FaassL-L-S---K--- 246
WP_011736621 212 rylcgrL--Tle---------qgLDrFSALMdARA-GA--VWMPDAEAAVDVDKLEDLRLVE-S----I-L-A---R-Qa 266
WP_015069579 188 ------L--D------------VTD-DVTCC-EHY-GYRVTLVEGSRMALKITEPLDLDIAE-T----L-V-K---A-T- 232
YP_003154369 197 ------LpgSgpspaeqggefgGFD-EVREA-LAR-GARVRTVHGSHAGFAVLDRLSLWQAQiS----LgLaRd-tShRh 262
WP_002521161 190 ------G--S------------VTD-DISCC-ERY-GHHATFVEGSRMSLKITEPVDLDVAE-V----F-A-K---A-A- 234
5DDT_A       227 ---SG 228
WP_015787781 218 ---GQ 219
WP_105187231 236 ---AG 237
WP_052809173 247 ---LA 248
WP_091803061 210 ---GT 211
WP_011096372 247 ---SN 248
WP_011736621 267 ---QR 268
WP_015069579 233 ---AG 234
YP_003154369 263 glaRH 267
WP_002521161 235 ---AG 236
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