Conserved Protein Domain Family
rpa1

?
TIGR00617: rpa1 
replication factor-a protein 1 (rpa1)
All proteins in this family for which functions are known are part of a multiprotein complex made up of homologs of RPA1, RPA2 and RPA3 that bind ssDNA and function in the recognition of DNA damage for nucleotide excision repairThis family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Statistics
?
PSSM-Id: 273177
Aligned: 7 rows
Threshold Bit Score: 837.076
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q19537    12 NKYHTNGKLRLTTGYvqeaIENNgypgHDGIVQVLKGKVEQGEQLGh-aFTFRIRISDGvFQYNALMSADIDDQIKREVE 90  Caenorhabditis elegans
P27694     2 VGQLSEGAIAAIMQK----GDTN----IKPILQVINIRPITTGNSP---PRYRLLMSDGlNTLSSFMLATQLNPLVEEEQ 70  human
Q24492     3 LASLSTGVIARIMH-----GEVV----DAPVLQILAIKKINSAADS---ERYRILISDGkYFNSYAMLASQLNVMQHNGE 70  fruit fly
CAA16702   3 EVSLTAGAIGKIMN-----GEVTteadMIPVLQVTDLKQIMAQQDPt-rERFRMVLSDG-TYLHQGMLGTDLNNLVKEGT 75  thale cress
Q92372     2 AERLSVGALRIINT-----SDASsf-pPNPILQVLTVKELNSNPTSgapKRYRVVLSDS-INYAQSMLSTQLNHLVAENK 74  Schizosaccharomyces...
P22336     3 SVQLSRGDFHSIFTN----KQRYdn-pTGGVYQVYNTRKSDGANSN---RKNLIMISDG-IYHMKALLRNQAASKFQSME 73  Saccharomyces cerev...
AAB71836   6 APSVTPGAVAFVLENas-pDAATgvpvPEIVLQVVDLKPIGT-------RFTFLASDGK--DKIKTMLLTQLAPEVRSGN 75  long-grained rice
Q19537    91 hLVEGTIIALTKFEIYDQgEGakncflikGYKILSRYHQVLTSPEVKPRSHSGKPDEHKGYrpniiiedvWPEAEGMAAD 170 Caenorhabditis elegans
P27694    71 -LSSNCVCQIHRFIVNTL-KD--------GRRVVILMELEVLKSAEAVGVKIGNPVPYNEG---------LGQPQVAPPA 131 human
Q24492    71 -LEEFTIVQLDKYVTSLVgKDg------aGKRVLIISELTVVNPGAEVKSKIGEPVTYEN-----------AAKQDLAPK 132 fruit fly
CAA16702  76 -LQPGSIVRLTRFVGDVI-K---------GRRIVIVPQLEVLK---QISDIIGHPVPGGK-----------HNDQRGADS 130 thale cress
Q92372    75 -LQKGAFVQLTQFTVNVM-KE---------RKILIVLGLNVLT-ELGVMDKIGNPAGLETVdal----rqQQNEQNNASA 138 Schizosaccharomyces...
P22336    74 -LQRGDIIRVIIAEPAIVrER--------KKYVLLVDDFELVQ---SRADMVNQTSTFLDNyf------sEHPNETLKDE 135 Saccharomyces cerev...
AAB71836  76 -IQNLGVIRVLDYTCNTIgEK--------QEKVLIITKLEVVFKALDSEIKCEAEKQEEKPail----lsPKEESVVLSK 142 long-grained rice
Q19537   171 YQENMANPPAAKAPKREfg--eEASYNRAAAPEATraraVPPPARRTASNTeRgVMPIAMVTPYVSNFKIHGMVSRKEEI 248 Caenorhabditis elegans
P27694   132 PAASPAASSRPQPQNGSsgmgsTVSKAYGASKTFGka-aGPSLSHTSGGTQsK-VVPIASLTPYQSKWTICARVTNKSQI 209 human
Q24492   133 PAVTSNSKP---IAKKE------PSHNNNNNIVMN-------SSINSGMTH-----PISSLSPYQNKWVIKARVTSKSGI 191 fruit fly
CAA16702 131 -GIKFNTTE----QQGSg-----IRQVNNIEPGRS----NAAISPQVGAPP-K-IIPVNALSPYSGRWTIKARVTNKAAL 194 thale cress
Q92372   139 PRTGISTSTNSFYGNNA------AATAPAPPPMMK-----KPAAPNSLSTI---IYPIEGLSPYQNKWTIRARVTNKSEV 204 Schizosaccharomyces...
P22336   136 DITDSGNVANQTNASNAg----VPDMLHSNSNLNAnerkFANENPNSQKTR-P-IFAIEQLSPYQNVWTIKARVSYKGEI 209 Saccharomyces cerev...
AAB71836 143 PTNAPPLPPVVLKPKQE-----VKSASQIVNEQRG----NAAPAARLAMTR-R-VHPLISLNPYQGNWIIKVRVTSKGNL 211 long-grained rice
Q19537   249 RTFPAKN--TKVFNFEITDsNGDTIRCTAFNEVAESLYTTITENLSYYLSGGSVKQANKKFNNTGHDYEITLRSDSIIEA 326 Caenorhabditis elegans
P27694   210 RTWSNSRgeGKLFSLELVD-ESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMP 288 human
Q24492   192 RTWSNARgeGKLFSMDLMD-ESGEIRATAFKEQCDKFYDLIQVDSVYYISKCQLKPANKQYSSLNNAYEMTFSGETVVQL 270 fruit fly
CAA16702 195 KQYSNPRgeGKVFNFDLLDaDGGEIRVTCFNAVADQFYDQIVVGNLYLISRGSLRPAQKNFNHLRNDYEIMLDNASTIKQ 274 thale cress
Q92372   205 KHWHNQRgeGKLFSVNLLD-ESGEIRATGFNDQVDAFYDILQEGSVYYISRCRVNIAKKQYTNVQNEYELMFERDTEIRK 283 Schizosaccharomyces...
P22336   210 KTWHNQRgdGKLFNVNFLD-TSGEIRATAFNDFATKFNEILQEGKVYYVSKAKLQPAKPQFTNLTHPYELNLDRDTVIEE 288 Saccharomyces cerev...
AAB71836 212 RTYKNARgeGCVFNVELTDvDGTQIQATMFNEAAKKFYPMFELGKVYYISKGSLRVANKQFKTVHNDYEMTLNENAVVEE 291 long-grained rice
Q19537   327 GGELLA--APKLILKRVKLGEIAGYAGQ--LIDVLVVVEKMDPEATEFTSKAGKSLIKREMELIDESGALVRLTLWGDEA 402 Caenorhabditis elegans
P27694   289 CEDDHH--LPTVQFDFTGIDDLENKSKDs-LVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDA 365 human
Q24492   271 CEDTDDdpIPEIKYNLVPISDVSGMENKa-AVDTIGICKEVGELQSFVARTTNKEFKKRDITLVDMSNSAISLTLWGDDA 349 fruit fly
CAA16702 275 CYEEDAa-IPRHQFHFRTIGDIESMENNc-IVDVIGIVSSISPTVTIT-RKNGTATPKRSLQLKDMSGRSVEVTMWGDFQ 351 thale cress
Q92372   284 AEDQTA--VPVAKFSFVSLQEVGDVAKDa-VIDVIGVLQNVGPVQQITSRATSRGFDKRDITIVDQTGYEMRVTLWGKTA 360 Schizosaccharomyces...
P22336   289 CFDESN--VPKTHFNFIKLDAIQNQEVNs-NVDVLGIIQTINPHFELTSRAG-KKFDRRDITIVDDSGFSISVGLWNQQA 364 Saccharomyces cerev...
AAB71836 292 AEGETF--IPQIQYNFVKIDQLGPYVGGreLVDVIGVVQSVSPTLSVRRKIDNETIPKRDIVVADDSSKTVTISLWNDLA 369 long-grained rice
Q19537   403 TKALv----dDYVQKVIAFKGVIPREFnGGFSLGTGSATRIISVPEIAGVSELYDWYANVKP-------TTEVKMMSQAA 471 Caenorhabditis elegans
P27694   366 DKFD------GSRQPVLAIKGARVSDF-GGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQal---dgVSISDLKSGGV 435 human
Q24492   350 VNFD------GHVQPVILVKGTRINEFnGGKSLSLGGGSIMKINPDIPEAHKLRGWFDNGGg-------DSVANMVSART 416 fruit fly
CAA16702 352 SLCD------SGVFPVLAVKAGRISEF-NGKTVSTIGSSQLFIDPDFVEAEKLKNWFEREGKsv---pcISLSREFSG-- 419 thale cress
Q92372   361 IEFS------VSEESILAFKGVKVNDF-QGRSLSMLTSSTMSVDPDIQESHLLKGWYDGQGRgqefakhSVISSTLST-- 431 Schizosaccharomyces...
P22336   365 LDFN------LPEGSVAAIKGVRVTDF-GGKSLSMGFSSTLIPNPEIPEAYALKGWYDSKGRn-----aNFITLKQEPGM 432 Saccharomyces cerev...
AAB71836 370 TTTGqelldmVDSAPIIAIKSLKVSDF-QGLSLSTVGRSTIVVNPDLPEAEQLRAWYDSEGKgts--maSIGSDMGASRV 446 long-grained rice
Q19537   472 GGS--------NEAPRTIAGLQEMQFGKdSDKGDYATVKAMITRVNPT-NALYRGCASEg----CQKKLVGEN-GDYRCE 537 Caenorhabditis elegans
P27694   436 GGS--------NTNWKTLYEVKSENLGQ-GDKPDYFSSVATVVYLRKE-NCMYQACPTQd----CNKKVIDQQnGLYRCE 501 human
Q24492   417 GGGs------fSTEWMTLKDARARNLGS-GDKPDYFQCKAVVHIVKQE-NAFYRACPQSd----CNKKVVDEGnDQFRCE 484 fruit fly
CAA16702 420 SGK--------VDVRKTISQIKDEKLGT-SEKPDWITVSATILYLKFD-NFCYTACPIMngdrpCSKKVTDNGdGTWRCE 489 thale cress
Q92372   432 TGR--------SAERKNIAEVQAEHLGM-SETPDYFSLKGTIVYIRKK-NVSYPACPAAd----CNKKVFDQG-GSWRCE 496 Schizosaccharomyces...
P22336   433 GGQsaasltkfIAQRITIARAQAENLGR-SEKGDFFSVKAAISFLKVD-NFAYPACSNEn----CNKKVLEQPdGTWRCE 506 Saccharomyces cerev...
AAB71836 447 GGArs-----mYSDRVFLSHITSDPNLG-QDKPVFFSLNAYISLIKPDqTMWYRAC-KT-----CNKKVTEAMgSGYWCE 514 long-grained rice
Q19537   538 KCNKNMNKFKWLYMMQFELSDETGQVYVTAFGDSAAKIVGKSAAELGELH--DESPDEYNAIFERLQFVPKMWRLRCKMD 615 Caenorhabditis elegans
P27694   502 KCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELK--DKNEQAFEEVFQNANFRSFIFRVRVKVE 579 human
Q24492   485 KCNALFPNFKYRLLINMSIGDWTSNRWVSSFNEVGEQLLGHTSQEVGEAL--ENDPAKAEQIFSALNFTSHIFKLRCKNE 562 fruit fly
CAA16702 490 KCDKSVDECDYRYILQLQIQDHTDLTCVTAFQEAGEEIMGISAKDLYYVKneHKDEEKFEDIIRKVAFTKYNFKLKVKEE 569 thale cress
Q92372   497 KCNKEYDAPQYRYIITIAVGDHTGQLWLNVFDDVGKLIMHKTADELNDLQ--ENDENAFMNCMAEACYMPYIFQCRAKQD 574 Schizosaccharomyces...
P22336   507 KCDTNNARPNWRYILTISIIDETNQLWLTLFDDQAKQLLGVDANTLMSLK--EEDPNEFTKITQSIQMNEYDFRIRARED 584 Saccharomyces cerev...
AAB71836 515 GCQKNDAECSLRYIMVIKVSDPTGEAWLSLFNDQAERIVGCSADELDRIRk-EEGDDSYLLKLKEATWVPHLFRVSVTQN 593 long-grained rice
Q19537   616 SYNEEVRQKMTVYGVDDVNQDKYIENLKQMIEQ 648 Caenorhabditis elegans
P27694   580 TYNDESRIKATVMDVKPVDYREYGRRLVMSIRR 612 human
Q24492   563 VYGDMTRNKLTVQSVAPINHKEYNKHLLKELQE 595 fruit fly
CAA16702 570 TFSDEQRVKATVVKVDKLNYSADTRTMLGAMDK 602 thale cress
Q92372   575 NFKGEMRVRYTVMSINQMDWKEESKRLINFIES 607 Schizosaccharomyces pombe 972h-
P22336   585 TYNDQSRIRYTVANLHSLNYRAEADYLADELSK 617 Saccharomyces cerevisiae S288c
AAB71836 594 EYMNEKRQRITVRSEAPVDHAAEAKYMLEEIAK 626 long-grained rice
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap