1Q74,4XM0


Conserved Protein Domain Family
PIG-L

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pfam02585: PIG-L 
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GlcNAc-PI de-N-acetylase
Members of this family are related to PIG-L an N-acetylglucosaminylphosphatidylinositol de-N-acetylase (EC:3.5.1.89) that catalyzes the second step in GPI biosynthesis.
Statistics
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PSSM-Id: 426852
Aligned: 66 rows
Threshold Bit Score: 58.4629
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1Q74_B            8 LFVHAHPDDES-LSNGATIAHYTSR--GAQVHVVTC--TL----GEEGEvigdrwaq--------ltadhadQLGGY--R 68  Mycobacteriu...
jgi:OSTLU_34729  58 LVLTSHPDDES-YFFAPTIQALKAA--NVETHLVCL--SD----GGAG------------------------GDGET--R 102
Q4CY46           36 LLVFAHPDDEA-MFFSPMLEHLRRY--DVKVHFLCL--SN----GNYE------------------------GLGAL--R 80  Trypanosoma ...
Q4WVL6           43 CLLIAHPDDEA-MFFSPTVLALTKPelGNHVKILCL--SS----GDAD------------------------GLGHI--R 89  Aspergillus ...
Q5KL67           59 LIVTAHPDDEV-MFFSPTILGLIGA--GWDVKGLCL--ST----GNSE------------------------GLGQK--R 103 Cryptococcus...
Q5UQW3           43 LMIIAHPDDELiFGSKELIE-------NPGWKVICI--TN----GSKKSvnkisi------------cylmgHRSTY--R 95  Acanthamoeba...
Q2J7M0            6 LLVSPHPDDLA-WSVGATVATLAGA--GHDLHAVTVfgRSryapGSAAHgd-------------------aaSVTAL--R 61  Frankia casu...
Q7N992            4 LFLSPHLDDAA-LSAGGLIHKLVSE--NQKVIILTF--FT-----EYDKdltshysh-------sahndniySFIKLysK 66  Photorhabdus...
jgi:Haur_0082    10 ICLSPHFDDAA-LSLGGALAGWHAA--GERCLIVTI--CSappsGELNQfaaylh------------erwgaASDPIaiR 72 
Q183M6            6 LFFTPHQDDET-LSMGSAIIEHVE---KSDTHVILC--TD----GSKSIirkvlddggscsyhikdvhkyslSESEFskD 75  Clostridioid...
1Q74_B           69 IGELTAA-L-RAL-GV--------SAPIYLGga--grWRDSGMAGtdqrsq------rrfvdaDPRQTVGALVAII---R 126 Mycobacteriu...
jgi:OSTLU_34729 103 KKELLRV-K-ELF-EL--------EGMCIVEae---dLMDGMTNAw-----------------PAKTVMTVLDEYT---G 148
Q4CY46           81 EKELGLS-A-QFM-GVh------rNNVKIVNhp---aLQDGMNKIw-----------------DAGLIRQEVLLYLqkaR 131 Trypanosoma ...
Q4WVL6           90 KKELQQS-A-KHL-GLra-----dSDVFIVDdp--arFPDSMTATw-----------------SESDISSLLASAF---- 138 Aspergillus ...
Q5KL67          104 KEEFIKS-Y-EAL-GIp------aENLEITDhp---dLPDGLTTKw-----------------NTTLVSTIIQDSLf-sH 153 Cryptococcus...
Q5UQW3           96 RDEFINM---MNLlHC---------QYEIWD------YEDNYFNSn----------------wNLKQLKNQLENLLr-eK 140 Acanthamoeba...
Q2J7M0           62 TAEDAAW-AdRHA-GA---------ALVSLR------LPDASLRGytddtem----gaaadpgLVRRVADGLAALA---A 117 Frankia casu...
Q7N992           67 RANEDIAfC-NKL-SVipihgkilDCIYRTDqygepmYKNSAMIYtgqih---------ksddASDMAQELIDKIL---L 132 Photorhabdus...
jgi:Haur_0082    73 RAEDQAA-A-NRL-GA---------DLLFLE------QHDAIYRHagydsaaaifgtpiaddlLWASLTTQLQALV---Q 131
Q183M6           76 RDEEFKDsC-EAM-GV---------KESNIH------IEDNRAHDge---------------lSKEKAREIILKYL---E 120 Clostridioid...
1Q74_B          127 EL---RP-------------------------HV---VVTYDPNGGygHPDHVHTHT--VTTAA 157 Mycobacterium tuberculosis
jgi:OSTLU_34729 149 GApttF--------------------------DY---VVTFDAGGVsgHLNHVCTYE--GTKQW 181
Q4CY46          132 NV------------------------------RT---VVTFDQWGVshHPNHIATHN--GVSLV 160 Trypanosoma cruzi
Q4WVL6          139 -----APdlasqsqssavrhrvpgtgpptatiDV---LITFDKHGIsnHPNHCSLYH--GAVHF 192 Aspergillus fumigatus
Q5KL67          154 PV------------------------------DI---IVTFDPKGItsHPNHVTLPSslALIPA 184 Cryptococcus neoformans
Q5UQW3          141 NY------------------------------KM---VLTHNLAGEygHTQHKTISK--LLYDI 169 Acanthamoeba polyphaga mimiv...
Q2J7M0          118 AV---RP-------------------------RF---LLAPMAVGG--HVDHEVVRR--AVDAV 146 Frankia casuarinae
Q7N992          133 NY---QP-------------------------DY---IYAPLGIGR--HVDHIIINN--LVPNI 161 Photorhabdus laumondii subsp...
jgi:Haur_0082   132 QY----P-------------------------DAi--WYAPLAVGN--HVDHQITHG--VAAKV 160
Q183M6          121 EY----P-------------------------DAkvkTVTPFKASGi-HEDHRALGE--AALEL 152 Clostridioides difficile 630
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