Conserved Protein Domain Family
DUF3987

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pfam13148: DUF3987 
Protein of unknown function (DUF3987)
A family of uncharacterized proteins found by clustering human gut metagenomic sequences.
Statistics
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PSSM-Id: 432994
Aligned: 74 rows
Threshold Bit Score: 208.652
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Hore_03470 297 QTPIDMSIMLIISALGTALANKGVVQIRKGYTEPLNIWTCTVLPAGNRKSPVFkKIMKPILDYEERKREEIEPERRHALK 376
WP_013547524   171 PAQRDVLLLGAITTLGACMERHARCLYGGK-MQSPCLQTFIVAPPASGKGALG-LLRQLVEPIHDEIRSQVERQMSKYRK 248 Bacteroides h...
Q8A787         174 PTQRDILLLGALTALGATMERYVRCSYSGKY-QSPCLQTFFVAPPASGKSGLS-LIRLLVEPIHDKIRQQVDEEMKAYRK 251 Bacteroides t...
jgi:Fluta_0595 324 HREKDVFLTTALAILSGCMPNVEGLYSQRKV--YPNLFCFVLAPPASGKGSMQ-SSKELADVYHNFTLQQSLELKKEYDR 400
CCX63002       359 RRERDMVLMAMLTHLSACLPDVHFHYDRHDM--RPHLYFAVVAPAATGKGIVT-QVSYLSHPLHDYYLARGEEEQAAYEA 435
CDC55626       406 GRQRDMLLMSILTNLSGCVPLVRTLYAHRLY--SPHFFFAAVAPAGSGKGVVA-LSALLGSKIHREMEENNRRERKEYEQ 482
CDD33785        40 HRQRDALLLGMLGILSGCEPGVRVRYANQEV--SPHLYVAVLGPAAAGKGVLA-YAASLAQPIHEELVEQWRKAMKEFST 116
wustl:BV2606   365 KRERDILLLSMITNISGCLPGVRMNYGGMVY--SADLYLVALAGSGRGKGVMQ-LAAILPAAIQEYYDELNRKDEREYRQ 441
Q5LBN5         365 PRERDMLLAAMIVNISACLPEVRLLYDQMYY--SPHLYYMVIAHAGGGKGVVG-LAGMLPAEIHKFYEKQNDEVRLVYDK 441 Bacteroides f...
Q8A9V6         371 ERERDGLLLSCITTISSMLPSVSIRYNRRNY--QPNIYCIVVASSGANKNLIG-YGIRLHKHYCEYWEKQSLKIEKEYKK 447 Bacteroides t...
jgi:Hore_03470 377 EKSILEDQLKQKEKIagnakdQAKRKQIMQEIFNLddeiqeMEIPTLPRLVA-SDVTTEKLAKLMEDNN-GRIAILSPEG 454
WP_013547524   249 ERCAYNALGKE----------RGQTEE--------------PQMPPNRMFIIsGNNTGTGILQNIMDSN-GTGIIFETEA 303 Bacteroides h...
Q8A787         252 EKKNYEL--------------LGKEHVNTEA----------PQMPPNKMFLIsGNNSGTGILQNIMDAN-GTGLICETEA 306 Bacteroides t...
jgi:Fluta_0595 401 QMRLLKNKRSA----------TNKNHEITDDGEV-------PEEPPFKVVFIpANTSSAQLYVHLKSND-EQGIICETEA 462
CCX63002       436 RLQQWNEDFSE----------RMRKGRKGEKPEPK------PKEPERIYFQIsPNTSKSMLYRQLWANReVSGVLHTSEI 499
CDC55626       483 KMLEWEAEQK-----------RAFREKRKPDISLK------PEEPRWHVLNVpPNTSKSQLMTDLYNSGeIGIICNTTEI 545
CDD33785       117 KRVAWELEQR-----------RALREKRMPDMELK------PEEPARQALLVpPNTSKSQLIADLETADdRGLICYTSEM 179
wustl:BV2606   442 KLLKWNLEER-----------LAAQEKRVPDLDQC------PEMPVERILKVaPNISKSQLILALEAGGaVGLVMNASEL 504
Q5LBN5         442 AFFEWELEQK-----------KAQAEKRSPDFALR------PREPLRKLLMLsPNVSKSLIISALEESGkLGCCINATEL 504 Bacteroides f...
Q8A9V6         448 ALRDYTLSLQAIRKK------NTAATNLPDE----------PEEPKLAFPLIpADISRAQLITHLINNQsCSSLLTSTEA 511 Bacteroides t...
jgi:Hore_03470 455 DIFKLMAgryskngAANFDNYKKAWTGGEPIrdDRMARKGT-YVKNPALTQGLTVQPVILEDLKekkAFKGEGILGRFLY 533
WP_013547524   304 DTISTAIgt---dyGHWSDTLRKAFDHDRLSynRRTDHEYR-EVKKSYLSVLLSGTPAQVKPLI---PSAENGLFSRQVF 376 Bacteroides h...
Q8A787         307 DTIASAIss---eyGHWSDTLRKAFDHDRLSynRRTDQEYR-EVKRIFLAVLLSGTPAQVRALI---PSAENGLFSRQLF 379 Bacteroides t...
jgi:Fluta_0595 463 DTLGAVFkn---ewGSYSDLLRKAFHHEKVSlsRKTNKEFI-DINNPRLSVALTGTPAQIFNII---PSAEDGLFSRFIF 535
CCX63002       500 DALSAAIgq---dyGKQDDVLRACFHHEPISssFKVDGKPV-FVPYPMLALCMTGTPMQFLSLV---HNTEDGLFSRLAA 572
CDC55626       546 DSFTAALgt---dyGKHASELRMIYHHEAVGqnYKIDGHPI-LIQRPRMAICMAGTLQQLVNFV---SSKEDGMYSRLAL 618
CDD33785       180 DAFTAAVat---dyGKHAPELRMIYHHEPVGlnYKGDGRMV-YVPHPRLAICMSGTLQQLVNFV---PYREDGMLSRICF 252
wustl:BV2606   505 DMISSAMhq---eyGKHDDVMRAASQHEEVSsyFKTDHRLV-VVSDPHLALCASGTPAQLHKFI---SSLENGMYSRVAF 577
Q5LBN5         505 DMVSGAIrn---ecGKHDDVFRAAFQHEVVSadFKVNGRQV-VARHPRLALCLAGTPNQLVRFI---PSLENGLYSRFLI 577 Bacteroides f...
Q8A9V6         512 SSVSTARnq---dyGHFDDILCKAFEHELISssYKINGRHPlKVEYPSLSAFLTGTPSSLILFI---PTMETGLYNRFLI 585 Bacteroides t...
jgi:Hore_03470 534 AIPESPvgSRKVGnevpELSDIavmRYQKGLSALLHTrP--AGENKNGEwEPHIIKLSPEALEVRYEFERDIEKELGPEG 611
WP_013547524   377 YYMPAIeqWQDQF----DHDDT---DMERLFSAIGIE-WkqQIEKLKQG-GLYTLKLSKEQRKEFNSTFAALFHRSHASH 447 Bacteroides h...
Q8A787         380 YYMHGIytWADQF----ACGEI---DLDEIFRSIGRD-WqlKLDILKEH-GIHTLRLTDEQKKEFNALFSDLFFRSDIAN 450 Bacteroides t...
jgi:Fluta_0595 536 YAFRSDsgWISPAp---DPNRV---NLTDHFDALSKE-VfeMVQFLEN--QPTTIELTSDQWAKLNDAFTEHLQEIIELA 606
CCX63002       573 YQVQPQyvWRDASa---EGQVQ---NLRTHFRELGKR-VlkMHEMMKG--RRTDVELTREQWRRHSTFFSRKLQEVVAEG 643
CDC55626       619 LTGKGEsgWISAApd-sDDEWI---DGDELFENLADD-VlqAYHFLLN--SPTSVHFTREQWKIHNKLFGHMMRNVSLED 691
CDD33785       253 YLLPSNpeWVSAEp---DEAAF---DLKKLFQQLGRE-VadLFHFLEK--NPTRVTFTKEQWRIHDRLFRSLLGRVLLED 323
wustl:BV2606   578 YVGQAHweYKSANp---GKARL---DMRAYFKGMGEE-LlrMFIFLSG--SPTEVVFTEEQWKEHTERFRTYLREVVAED 648
Q5LBN5         578 YTGQSAweWRSAAp---RAGCE---DHRAVFARLSAR-LleLHQFLLQ--SPTEVTFTPGQWEEHTLRFASHLSEVVNER 648 Bacteroides f...
Q8A9V6         586 NTFRLPaaWQDVFa----EEKV---RADDLFNELSMR-FaqMALFLKD--SPTEVKLTDTQKKEFNRVFTQLLKDTDQLG 655 Bacteroides t...
jgi:Hore_03470 612 KLHnIADWGSKLVGNITRVAGLLHIAG-----------------------------QTDaqkgqatrdIWNKPIGPETMK 662
WP_013547524   448 GTE-MSSSVARLAVNICRIATVVGLLRgnltpda---------------elppdnlKDGii------tRWDIHLCKADFE 505 Bacteroides h...
Q8A787         451 GNE-MRSFIARLAVNICRIMSTIAMLRvleipqpyqlkssdryapvpdkeiptdnvKDGii------tRWDITITPEDFK 523 Bacteroides t...
jgi:Fluta_0595 607 GEE-ATSIVKRMGLVLYRICMIFSTLRk---------------------------fENGd-------cSETIICEDIDFD 651
CCX63002       644 GER-MASSVMRMGLIAARIAAVLTALRk---------------------------gEDElw------aMSTRYCSDEDLD 689
CDC55626       692 GEG-NEAIVGRHGLLTMRIAMVLTALRk---------------------------wEAGw-------nMKDVTCSDEDFS 736
CDD33785       324 EEN-TQSIVNRHGLMMIRIATLLTAIRk---------------------------yEQRs-------vAKQCICTDVDFR 368
wustl:BV2606   649 DDS-PGAIVLRHGLMMSRIAMVLTALRk---------------------------cEPQw-------nTSEWKCSDEDFH 693
Q5LBN5         649 DDS-PGAIVLRHGLMASRIACVLTVLRk---------------------------gECAw-------aMPEYACSDEDFH 693 Bacteroides f...
Q8A9V6         656 NDD-LLGVVKRYGVITARICCIFSAIDk---------------------------gTMRm-------eTPEVYCSDAHFK 700 Bacteroides t...
jgi:Hore_03470 663 KAVKLGYSLIEHALKVYDL 681
WP_013547524   506 AVLALAEPFYRHATHILSF 524 Bacteroides helcogenes
Q8A787         524 AVLGLVKPLYRHATHILSF 542 Bacteroides thetaiotaomicron
jgi:Fluta_0595 652 SAATLVNTYIQHSILMFAN 670
CCX63002       690 ASLAIAAVLLEHALLLSSS 708
CDC55626       737 ITIELVKVLLEHSLSLSTI 755
CDD33785       369 TALSLVQTMLVHSLRVSTM 387
wustl:BV2606   694 TAMQIVDVLLEHSLLLSTS 712
Q5LBN5         694 TAMLMTDVLLEHSLLLSTC 712 Bacteroides fragilis NCTC 9343
Q8A9V6         701 AALAIVLCCFEHSKLVSTS 719 Bacteroides thetaiotaomicron
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