Conserved Protein Domain Family
THRAP3_BCLAF1

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pfam15440: THRAP3_BCLAF1 
THRAP3/BCLAF1 family
This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).
Statistics
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PSSM-Id: 464718
Aligned: 25 rows
Threshold Bit Score: 307.09
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014352806 125 PRSRSRSPKRRSV-TPRSRSCSRNSD-----------------------RSSSGrs--rsSSSGSSshhSRSGS-SKRRS 177 
XP_008112728 108 DRSRSRSPKRRSRsSQRSRSRSRRSY-----------------------RSSrsp---rsSSSRSSspySKSPVsSKRRG 161 
XP_006007788 107 GRSRSRTPKRRSVsSPRSRSRSHHSD-----------------------RSSvsr---gsSSSRSSscySQSPVpSKLRS 160 
XP_007668710 123 GRSRSRSPKRRSP-SPRSRSHSRNSD-----------------------KSSSDrsr-rsSSSRSSsnhSRVES-SKRRS 176 
XP_023355937 123 GRSRSRSPKRRSP-SPRSRSHSRNSD-----------------------KSSSDrsr-rsSSSRSSsnhSRVES-SKRKS 176 
Q569Z6       123 GRSRSRSPKRRSP-SPRSRSHSRNSD-----------------------KSSSDrsr-rsSSSRSSsnhSRVES-SKRKS 176  house mouse
XP_011479419 141 GRSRSRTPKKRSP----SRSRSRYSD-----------------------RSSSGpsrhsrRSSYSSrshSSSPR-HRSSK 192 
XP_011483948 110 QQNRSGSP---------PQGQSHRTD-----------------------RSFSPlsr-hsHHSSSSt-hSSPPK-ARQAT 154 
XP_015204189 126 qhsprrgrsrsrspkrrsgtprsrsrsrysdrsssgrsrrtrgssssdsrsssthsrsgsskrnaakelkeSGR-PDSAA 204  spotted gar
XP_015204191 132 GRSRSRSPKRRSG-TPRSRSRSRysdrsssgrsrrtrgssssdsrsssthsRSGssk-----rnAAkelKESGR-PDSAA 204  spotted gar
XP_014352806 178 VKQHNAAQKEARASLPPAQVSQGAESKAKppadatsndskdpeaiskpwkgltaydsspkhpssvvhsvnasglnSPP-H 256 
XP_008112728 162 SSEKQAKKTEAATLQESPLKNKSQEEEKSafehdpseplddfnks--------------aaasgdiwpglsaydnSPRsP 227 
XP_006007788 161 SLEKQPKKTEGVLSEDKASGSRQQEEKKDlgkfepdqsklhdefskv-----------stlggdswpglsayndnSPRsH 229 
XP_007668710 177 GKDKKSSSKDARSSQATGD-NQGDDTKEQsfsgaaaqdakpsegskpwp-------eataygagsgsrasasaelSPR-E 247 
XP_023355937 177 VKEKKSSSKDNRPSQAAGD-NQGDDSKEQpfpggtsqdakpsesskpw--------peatiygagsasraavselSPR-E 246 
Q569Z6       177 TKEKKSSSKDSRPSQAAGD-NQGDEAKEQtfsggtsqdikgsesskpw--------pdattygagsasrasvsdlSPR-E 246  house mouse
XP_011479419 193 GRRSSKDVKDKRTEGSAEKpgqvgeggniek---------------------------------asggkwidfdaSPK-R 238 
XP_011483948 155 GLASQTSEDVKDGELTSKQVQKGGEEDEEpeehvelleenpt--------------------egagsgksdgnwqSPK-K 213 
XP_015204189 205 KEAQRAGSRDEEAAGAAGGegapdrasgs-------------------------------------wqglidydtSPK-R 246  spotted gar
XP_015204191 205 KEAQRAGSRDEEAAGAAGGegapdrasgs-------------------------------------wqglidydtSPK-R 246  spotted gar
XP_014352806 257 PSPiqk-------------spLQSVAVKRSPPQKSPQSHSPAGPSSLRQSPVPPi-----------Ppl----------- 301 
XP_008112728 228 HSP---------------------------S-IASPPSQSSSCSDAHLLSTVHSa-----------Kdtpqhs------h 262 
XP_006007788 230 QSP---------------------------SPVPTPTSHSSSRSDVALQSIAHSa-----------Sgsskigaptqrsh 271 
XP_007668710 248 RSPalk-------------spLQSVVVRRRSPRPGPG-----------QKPSPPl-----------Sgtsqlgsalqsgp 292 
XP_023355937 247 RSPalk-------------spLQSVVVRRRSPRPSPV-----------QKPSPPl-----------Stpsqmgsalqsgt 291 
Q569Z6       247 RSPalk-------------spLQSVVVRRRSPRPSPV-----------PKPSPPl-----------Snasqmgssmsgga 291  house mouse
XP_011479419 239 GSP---------------------DRKKEGTPSTSEGRGGGASMWKSVGSPSPP-------------------------- 271 
XP_011483948 214 NS-------------------LGPSSVGQKSPSPGQTINTKISNDTSNGAPVw--------------------------- 247 
XP_015204189 247 TSPavrsaiivsqgtahpspsLQSVAVKR----PSPAVKG--------GSPSPSrssaaaqskslgNapwqssgpaptsk 314  spotted gar
XP_015204191 247 TSPavrsaiivsqgtahpspsLQSVAVKR----PSPAVKG--------GSPSPSr-----------Ssaaaqskslgnap 303  spotted gar
XP_014352806 302 --rtVPRQSPQAh---SPKRSSPAERSPV-----RKSPPIISTSYN-NAQKE--------ESRAGESTSplVSSYLKRYL 362 
XP_008112728 263 siqhSPERSGSGslgnGSSRYSPSQNSPLhhipsRRSPAKAVASQNaTREETrvrs-fypEAGEPESSK--GAKFLKRYT 339 
XP_006007788 272 siqrSPERAGS-----NTSRYSPSQDSPLhhmssRKSPVKSVTGQSlSREEArgrssfysDTEEKELPK--SGKYLKRYT 344 
XP_007668710 293 gfqaGSHQGPFDh---GAGGLSPTRKSPV-----CKSPPALSSVYG-SSQKE-------------EGAApgGAAYSKRYL 350 
XP_023355937 292 gfqaGAHQSQFDh---GAGGMSPSKKSPV-----GKSPPAIGSTYGsSSQKE-------------EVSApgGAAYSKRYL 350 
Q569Z6       292 gyqsGAHQGQFDh---GSGSLSPSKKSPV-----GKSPPATGSAYG-SSQKE-------------ESAAsgGAAYSKRYL 349  house mouse
XP_011479419 272 ------------------------PKSPA-----KSGQSATFSGFG-FFSKD--------DAKPADNSA--ISAAFKKFL 311 
XP_011483948 248 ----------------QSSGGTCSTRKPS-----REGLNPMLSSFD-FFSTE--------EFQDEDKKA--ISIAFRKFL 295 
XP_015204189 315 sppqQSPTAVFSgfgfFSKDDVRAGEKPSsvstaFK-----------------------------------------KFL 353  spotted gar
XP_015204191 304 wqssGP---------------APTSKSPP-----QQSPTAVFSGFG-FFSKD--------DVRAGEkp-ssVSTAFKKFL 353  spotted gar
XP_014352806 363 EEQKNKATTQDRENGREKDqk-akNEEREKVK----------ERSGVSEMGV--PFFKSDYLAPKNESESLYRGIPSPRR 429 
XP_008112728 340 D-EESRVYLLDRSNVREKDaqkerGPEKGRTE----------GEREWEDQDAleYYMDKDSGKQKFI-DSEGEDAEETED 407 
XP_006007788 345 DEEETGAYLLDKSNVKEKDgqkdrGLDKGRVE----------QDSEWEDQEAleYFEQKDSDKLPFLGDSEGEGGEKPDT 414 
XP_007668710 351 DEQKA-------ENGKDKEqk-ltGVDKEKMK----------EKGSFSELGLgdAKMKSEPFAPKPDAEKPFRSSQSPKR 412 
XP_023355937 351 EEQKS-------ENGKDKEqk-ltNVDKEKIK----------EKGSFSELGLgdSKVKSDPFAPKADTEKPFRGSQSPKR 412 
Q569Z6       350 EEQKT-------ENGKDKEqk-qtNADKEKLK----------EKGGFSDa---dVKMKSDPFAPKTDSEKPFRGSQSPKR 408  house mouse
XP_011479419 312 AENKSKKQAAEKESSREKEal-aaDREQEKSS----------KSAEIFSV-----------------SSSAYADSKDDKS 363 
XP_011483948 296 EEQSKKANTTA-EISPKTEae-dgGLEKGNMN----------GKTSAM-------------------VSDCASGKCKEKT 344 
XP_015204189 354 EEHKNKIQVAEWENGREKEqk-maELERDKGNgkagsfdkgaAYSGLK-------------------------------- 400  spotted gar
XP_015204191 354 EEHKNKIQVAEWENGREKEqk-maELERDKGN----------GKAGSFDKGAaySGLKPDYYSKNEE-----------EK 411  spotted gar
XP_014352806 430 YRYSNELEKsmSAE----------------FQE--EALHSMDMQ--------ESEkkhrvkgl--kdskledePKCKSKV 481 
XP_008112728 408 YR---QFRKsvLAD----------------QGKg-fSASHRNAE--------EEG------------------SKYKSKI 441 
XP_006007788 415 YR---QFKVssQVE----------------QVKsyLAETRWNDD--------DEG------------------NKFKTKI 449 
XP_007668710 413 YKLRDDFEKk-LAE----------------FH-------KEEMD--------EQDkkdkakgr--kesefddePKFMSKV 458 
XP_023355937 413 YKLRDDFEKk-MAE----------------FHKeeMDEQDKEKVkgrkesefEDE------------------PKFMSKV 457 
Q569Z6       409 YKLRDDFEKk-MAD----------------FH-------KEELD--------EHDkdkskgrk---epefddePKFMSKV 453  house mouse
XP_011479419 364 LPFFDPEEE----E----------------FLK--SQGLKERVIp-------DDA------------------D--AQRT 394 
XP_011483948 345 KG-----EVs-LKS----------------FLKtpPFLSTEGEE--------EDEilhrpslkflfkdlhngdESCKPKI 394 
XP_015204189 401 -----PDYYskNEEekygyddefelgsaaeFLKgpQFGSAEAGE--------DQEkrhkvrnq--keremedePKHKSKI 465  spotted gar
XP_015204191 412 YGYDDEFELgsAAE----------------FLKgpQFGSAEAGE--------DQEkrhkvrnq--keremedePKHKSKI 465  spotted gar
XP_014352806 482 IvpSTAKNQDTYEERLSKWEE---LAYFPSAKEkSWEDE--------DMEDEVYPGR--AKREE--------VKRAElGG 540 
XP_008112728 442 SmkVNRESEGFREDKNYKLKEpasYVVERPNIPkDKHKEd-----------EKISERt-MKKETqspeqvksEKLKElFD 509 
XP_006007788 450 VlkGDRDYDRFGEDRAFKLKGs-gFGADRPSTSkEKYREd-----------DKFLERimIKREPvspeqvksEKLSErFD 517 
XP_007668710 459 La-GSSKNQE--EDRPGKWEG---LVYLPGGKEkPRKTE--------EPEEDSYAER--AKKEErs-----tGKRAEg-G 516 
XP_023355937 458 Ia-GTSKGQE--DERPGKWEG---LVYVPTGKEkQRKAE--------ELEDDPYADR--PKKEEra-----tTKRTEaTA 516 
Q569Z6       454 Ia-GASKNQE--EEKSGKWES------LHTGKEkQRKAE--------EMEDEPFTER--SRKEErg-----gSKRSEs-G 508  house mouse
XP_011479419 395 P-----TARDIF----GKWGDepsISTSYSSKEkARREAadp---sdAMEDEMYQVRklSKKEEkskkkekkEKEKQ--R 460 
XP_011483948 395 S------AQKLFGEAFRKQQN--------AAYSqFTNGEf------dSREEERWVER----KQDkaaaisavLAKRElTE 450 
XP_015204189 466 Ti---TANRDMFDERFNKWDE---LAYFPSAKEkLRKEEdageddidDVEEELY--R--SRKQEraaaaaaaakkaeasg 535  spotted gar
XP_015204191 466 Ti---TANRDMFDERFNKWDE---LAYFPSAKEkLRKEEdageddidDVEEELY--R--SRKQEraaaaaaaAKKAEaSG 535  spotted gar
XP_014352806 541 yrgpipdknprsgsy-----kvvherspsppprrSAEGKE-REKMATKEENPpisk-ttfSVYRGSEINVRMdALEDDFG 613 
XP_008112728 510 ys------------------------------ppLHKNPDsREKSTFREESPlrik-miaSDSHRPEVKLKMaPVPLDDS 558 
XP_006007788 518 cs------------------------------plLQKTLDlREKAASREENLpkik-mvpSESYRPDVKLKMpPVSFDDP 566 
XP_007668710 517 hrgfvpeknfrvt--------aykavqekgssppPRKASDsREKPGARGDSLplgk-ssfSITREAQVNVRMdSFDEDLA 587 
XP_023355937 517 hrgfvpeknfrvtaykalpekssspppppprkatTSASAEaRDKLGPPRAESlplgkssfSITREAQVNVRMdSFDEDLA 596 
Q569Z6       509 hrgfvpeknfrvt--------aykavqeksssppPRKTSEsRDKLGSKGDFssgk--ssfSITREAQVNVRMdSFDEDLA 578  house mouse
XP_011479419 461 ----------------------------------RSASPQmKERPLFPGAFPpsdp-spvRPLSASREDFEL-KFSSLEE 504 
XP_011483948 451 kfedlspemsfk----------kkmmagspsvlaSAAVSSnREMFMIREQDPap----vsSQKPEAKFHVRMgFLGDSLM 516 
XP_015204189 536 yrgfspd-----kapkasrkkekqgqspspparkSSENRE-REMFNVRRDDSpprstpaySGKRSAEVSVRMdPFHEDYA 609  spotted gar
XP_015204191 536 yrgfspdkapkasrk-----kekqgqspspparkSSENRE-REMFNVRRDDSpprstpaySGKRSAEVSVRMdPFHEDYA 609  spotted gar
XP_014352806 614 -SS---VAHERRLSRDLVHGNKKDLGFRSIFQHIQSSQSRRSPSELFAQHIVTIVHHVKEHHFESPEMTLSERFTMYQRR 689 
XP_008112728 559 nRPa-sLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHVVSLVHHVKEQYFKSAAMTLSERFTAYQKS 637 
XP_006007788 567 vRPgtsLTSDRLLASALVHSGKKEQGFRSIFDHIKLPQMYKSSAESFIQHIVSLVHHVKEHYFKSTGMTLNERFTVYQKA 646 
XP_007668710 588 -RPsglLAQERKLCRDLVHSNKKEQEFRSIFQHIQSAQSQRSPSELFAQHIVTIVHHVKEHHFGSSGMTLNERFTKYLKR 666 
XP_023355937 597 -RPsglLAQERKLCRDLVHSNKKDQEFRSIFQHIQSAQSQRSPSELFAQHIVTIVHHVKEHHFGSSGMTLNERFTKYLKR 675 
Q569Z6       579 -RPsglLAQERKLCRDLVHSNKKEQEFRSIFQHIQSAQSQRSPSELFAQHIVTIVHHVKEHHFGSSGMTLHERFTKYLKR 657  house mouse
XP_011479419 505 -LPsssLSKDRLIPRDLPNSSKKDPEFRSIFQHVQSAQLRRSPSELFAQHIVSIVHYIKAQHFPSSDISLSERFAMYQRK 583 
XP_011483948 517 -SSsdiLAEERQLSQDLVLSSKKDPEFRSIFQHVQTAQSQRSPSELFAQHIVTIVHHVKTQHFPSSGLTLNERFTLYQRE 595 
XP_015204189 610 -SSsgvLANERRFSRDLVHPSKKDQEFRSIFQHIQSTQLRRSPSELFAQHIVTIVHHIKAQHFESSGMTLNERFAMYQRR 688  spotted gar
XP_015204191 610 -SSsgvLANERRFSRDLVHPSKKDQEFRSIFQHIQSTQLRRSPSELFAQHIVTIVHHIKAQHFESSGMTLNERFAMYQRR 688  spotted gar
XP_014352806 690 AMEQGAARSKKSPEFHRRIDISPSAFRKHPFLQDEMKGSREsssykgegKYKeDPVDLRLDIERRKKY--KERDHKRDGS 767 
XP_008112728 638 --PEEHSTRQKSPEIHRRIDISPSALRKHTRLAGEERAFKEetqk-gdkKLKcDAADLRHDIDRRRKErsKER------- 707 
XP_006007788 647 --TEGQVPRQKSPEIHRRIDISPSALRKHTRLTDEDRLFKEesqkqgdkKLRcDSADLRHDIDRRRKErsRER------- 717 
XP_007668710 667 GTEQDAAKNKKSPEIHRRIDISPSTFRKHGLAHEEMKSPREpgyk-aegKFKdDPVDLRLDIERRKKH--KERDLKRDKS 743 
XP_023355937 676 GTEQDAAKNKKSPEIHRRIDISPSKFRKHGLAHDEMKSTREpgyk-aegKYKdDPVDLRLDIERRKKH--KERDLKRDKS 752 
Q569Z6       658 GNEQEAAKNKKSPEIHRRIDISPSTFRKHGLTHEELKSPREpgyk-aegKYKdDPVDLRLDIERRKKH--KERDLKRGKS 734  house mouse
XP_011479419 584 AAEAEMMKPRKSPEIHRRIDVSPSAFKRHPHLFEDLDEssyk---dpgkKFKgDVMDLRLDIERRKRFagRERDYKREGG 660 
XP_011483948 596 AAEQEMKKSRKSPEIHRRIDVLPSAFKKPPQLFGGVKSSEEgtyksageKVKgDTMDLRLDIERRKKYscFQNQNQE--- 672 
XP_015204189 689 AA--EMMKPRKSPEIHRRIDVSPSAFRKHSHLFEEMKSSREssskdegkKMKtDSMDLRLDIERRKKYssKEREHKRDGM 766  spotted gar
XP_015204191 689 AA--EMMKPRKSPEIHRRIDVSPSAFRKHSHLFEEMKSSREssskdegkKMKtDSMDLRLDIERRKKYssKEREHKRDGM 766  spotted gar
XP_014352806 768 RESVDSRDSSQSRERsTEKAQR---EHKESKKR-KKQkKIRSR-------SKSSSTSSHSSQSYKG 822 
XP_008112728 708 GDSKGSRESSGSRKQ--EKMPK---DYKDFKPYkDDSkQKREQdrsrsssTSSPSSSSSSSREEKD 768 
XP_006007788 718 EGSRGSRESSGSRKH--EKSTKdymDYKEYKPYkDESkPKNREg-----dHSRSSSSSSASRDDKD 776 
XP_007668710 744 RESVDSRDSSPSRERsAEKTEK---THKGSKKQ-KKHrRTRDR-------SRSSSSTSQSSHSYKA 798 
XP_023355937 753 RESVDSRDSSHSRERsTEKTEK---THKGSKKQ-KKHrRTRDR-------SRSSSSSSQSSHSYKA 807 
Q569Z6       735 RESVDSRDSSHSRERsTEKTEK---THKGSKKQ-KKHrRARDR-------SRSSSSSSQSSHSYKA 789  house mouse
XP_011479419 661 RSPEGSRGP--SREQsTEKSGK---HQKKSKKSk----KKRDR----------------------S 695 
XP_011483948 673 RDVGDSADF--SKELcEQNLSK---HSNKLNGQk----RRRSS----------SSSSSSSSKSPKP 719 
XP_015204189 767 RDSGESRGSSLSRERsTEKSSK---HHKKTKKRk----KTRER-------SRSSSESSSSSHSFKG 818  spotted gar
XP_015204191 767 RDSGESRGSSLSRERsTEKSSK---HHKKTKKRk----KTRER-------SRSSSESSSSSHSFKG 818  spotted gar
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