Conserved Protein Domain Family
DUF4457

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pfam14652: DUF4457 
Domain of unknown function (DUF4457)
This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.
Statistics
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PSSM-Id: 464238
Aligned: 19 rows
Threshold Bit Score: 415.136
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003291217 1304 FSFLSTWGDRFYMGLTS------IMIF-DNEYKQIPLTVLNITAHPKDINDVpGHSGDYRTLDKLIDGHNITTNDKHMWL 1376
2_pfamImport    1 LQLHNTWGDRNYIGLTQ------VEVLvGSRGTSIPLDAANIDATPRDLASL-GYVGDPRTLDKLIDGEATTCDDTHMWL 73  
EEY56508      513 LILEANWGDPYEIGLAG------LEFL-DSSYVPLSISLDSVTISAp------IAEDRMKKLLTTHGARHLAVDPEEMWT 579 
EFA83430     1789 IQFKSTWGDRYYLGLTS------IEVY-DENYQLIKLQLSNLIANPKDINDLpGHSGDYRTLDKLIDGKNVTTDDQHMWM 1861
Q553C0       2012 FLFLSTWGDRFYMGLTS------IMVF-DNEYKQIPIQASNITAQPKDINDVpGHSGDYRTLDKLIDGHNVTTNDKHMWL 2084 Dictyostelium...
EFJ29125      305 LNLLRSWGDCYYFGLTGiqahlfLQVL-DENGNAHSIQSEFITGKPRDLNDIpGHTGDYRTLDKLVDGCNVTTDDRHMWL 383 
A0DSF5       1016 IKLLRPWADQPYIGLTG------VEIY-GKEGK---IQVKNIKSDYQS-------DGDKGNIVSLINGINVTTNDMNMYI 1078 Paramecium te...
XP_004994397 1496 LNFVETWGDPYYLGLTG------LQLI-DEHGGVIAVSMRQVEAVPRDLNDLpNVYDDDRTLDKLFDGTNITTDDEHMWL 1568
4_pfamImport    1 LRLISNWGGSH-IGLVG------LQML-GEESELIPIELHRIKLMTNELAG----GGDASDINRIINGTNITMDSNKMWQ 68  
XP_001640011  252 LNFASTWGDPYYLGLTG------LELL-TPQMVPIPLNIDMLQANPRDLNDLpDYGDDDRTLDKIVDGTNVTTSDEHMWL 324 
XP_003291217 1377 IPFY-PSKEH-----TLTIDLGVPMSISCIRVWNYNKSVEDSSRGAKKVNIYLDGNSLCGGN------------------ 1432
2_pfamImport   74 VPME-AASVP-----EVRIEFKKGQYFFGLRIWNYNKSSEDSFRGVKQLTVALDGVVISPKEt----------------- 130 
EEY56508      580 APLR-EVLALplerrAITITFSEKVSLRALKIWNYNTTLEGSFKGTKQVSVRIDGVHHTRVS------------------ 640 
EFA83430     1862 IPFR-QKHQHdqtdyHLTLDLGVETTLSCLRVWNYNKNADDASRGAKEVVISLDGKCLTS-------------------- 1920
Q553C0       2085 IPFS-PSKEH-----VLTIDLGNVFSISCIRIWNYNKSLDDASRGAKKVNIFLDGQSLSPPPaaaassssssssplnniq 2158 Dictyostelium...
EFJ29125      384 VPYDgPEAEH-----FLEIDFKRPVTMSAFRFWNYNKSLDDTFRGVKWIQVLVDNVEVSPAG------------------ 440 
A0DSF5       1079 LPFQ-PGRCI-----TLTFTFDIPQLITSIRIWNYNKSYDDTFRGAKFISLQNDQGIISNCI------------------ 1134 Paramecium te...
XP_004994397 1569 IPFT-PTGDH-----LITFFFDTPTTVSALRFYNYNKSADDIYRGAKRVFVSVDDTDVSPSG------------------ 1624
4_pfamImport   69 IPFS--GNPC-----VISVNFVQAVQITGFRVWNYNASFEDTYSGVKEVVIELDGQVFTTNS------------------ 123 
XP_001640011  325 IPFT-DGEDH-----TLTIDLGLKTELLGMRVWNYNKSLDGTFRGAKIVHVSLDGKLISPPE------------------ 380 
XP_003291217 1433 -------NncFIFRKAPGNSI-FD--FGQTISLynWNKQNVsppstSSSVEQPLTSsktNISSIVPQPRSLDNYPSGFTL 1502
2_pfamImport  131 -------G--FLLRKAPGAAN-FD--FGQLLRF--PDIVEK-----RVTYPFSTRA---YKTPIIRQDYEAQLYPQGFLL 188 
EEY56508      641 ------------LRKAPGNLMdFD--FGQFLYLq-AECTRP-----SSPRLIRKKSa-mKPIAEVFQQYQTPLFPTGYII 699 
EFA83430     1921 -------G--YIFRKAPGESN-FD--YGQTLSFihHDKHSQ-----ESISESYDKMmifSKQSYIPQDYKTLFIPSGFVF 1983
Q553C0       2159 nnnqnnyG--FIFRKAPGNST-FD--FGQTISFfnWDKLNNn---nNNNINNNNNPp-sSCSSGTDQNKISQY-SSGFVL 2228 Dictyostelium...
EFJ29125      441 -------G--FLLRK--GMC--FNliFQSQLGFqlPGRTKN-----VKQRRIYAKL--------VLQEYLTPLFPSGHVI 494 
A0DSF5       1135 -----------ALKRAPGCDT-YD--YAQTITIpsKEYVFEe----TTQVQKQLRC-----------EYEINNLMVGHEL 1185 Paramecium te...
XP_004994397 1625 -------G--YLICIAPGSAA-FD--FAHTVSLhpRHRRYPpasihHKQLTPRWNA---------TNSYIVPAPPRVLRL 1683
4_pfamImport  124 ----------FVLRRAPGHVH-YD--FAQDVHF--ESKKAAlv--gSPSFKPKNNAi-tAHNHPHSDQYETPNAPTGFVY 185 
XP_001640011  381 -------G--YLLRKGPGNVH-FD--FAQDVYF---SGRTStggilVRPNRSQSRV----NIRKLIPDYEPALMPTGFVF 441 
XP_003291217 1503 KVLIISNHGDKNLVGLNAIEFYDQNDNLIKSSKSNILTNd-tKYSFRVV--ENGLT---HLENQGILIPFYS-VSFGS-- 1573
2_pfamImport  189 KIVCWQTWGDPYYLGLNGLELYDFAGARIDHKPAIVSAV---PYSVSEL--DHTNGrqqDTRTPDNLMSGLDkNTWEA-- 261 
EEY56508      700 KFVFSSTWGDTFYLGLNGVELFDRDNQLIPLYSEIVDAQ---PRDINVLkePGATH---DVRTLDKLYDGVN-NTYDD-- 770 
EFA83430     1984 KFVLLSSWGDKSYLGLNGMQLFDWNEDLIDVSKSRTVLL---PPALN----NASND-----QTLSRLFDGIN-SGFDE-- 2048
Q553C0       2229 KLVIISNYGDRNFVGLHAIEIYDQNDTIIKPNKSSVLSNd-vKNSYKLIgnNLSFQeseGFLIPYFSVSFGNsNNNNGms 2307 Dictyostelium...
EFJ29125      495 KFVLLSTWGDHQYLGLNGIELFDELGQSVPVLKRILRALtyaPDNVHVL--PDMTT---HFSNPEKLFNGVN-NTWDT-- 566 
A0DSF5       1186 KIQLITTFGDIHYIGLNGLEILDYKGRQV---QGNIGAE---PSSVRIL--QSMRG---DKRVVENLLDGIN-ETQND-- 1251 Paramecium te...
XP_004994397 1684 SLRLIDTWGDLHYIGLNGLQLLDAFGAEIPLTPQNIHAV---PESVNVL--PGVSG---DARTPDKLVDGHY-NTNND-- 1752
4_pfamImport  186 KFELLDTWGDLYYIGLNGLELYDEHGQLLKLTENEIAAF---PSSVNIL--DQSLD---DVRTPDKLINGIN-DTLDG-- 254 
XP_001640011  442 QFQLLSSWGDPYYVGLNGIEFYDSEGYRIRLRASDVTAY---PHSVNVL--DGVTD---DVRTPDKLVDGVN-DTMDG-- 510 
XP_003291217 1574 --LHQhlphntqLCQQfpqypsp--nknsnnrAEPPSFSKennvIYFYFNSPIIISKIKIWNYYKVPAQAIKDFAVYLDD 1649
2_pfamImport  262 --HDA-------WLAP----------------LASSLGNQqgniVYIGFDTPVVLSMIKFWNYSKTPERGVKDLDIYLDD 316 
EEY56508      771 --RHM-------WLAP----------------HTPSHPNK----LVLFFNEPMTISKIRLWNYSKTPTRGVREFEVFLDD 821 
EFA83430     2049 --KHA-------WCTHalyp---------ydrSSTGLIPIs---ICLYFDYPISLSMVKIWNYSRVPTRGVEEFAMYIDD 2107
Q553C0       2308 plYHQ-------QQQQqyqlggnsvsynsrglEIPSFSKEsn-vIYFYFDSPITVGKIKIWNYFKNISQAIKEYSIYLDD 2379 Dictyostelium...
EFJ29125      567 --QNM-------WLSV----------------RDYTEGNQ----IYLYFNEPVMLSLVKIWNYSRNPTFGVREIEILVDD 617 
A0DSF5       1252 --THM-------WLAPftnr--------cfdhSQDPQINS----LYFGSEQPFALGCIVFWNYTKTPARGVHEIAISLDD 1310 Paramecium te...
XP_004994397 1753 --YHM-------WLTP----------------HTPGKAAV----VEVLLPQPIMLGALKLWNYSKTPKRGVRHLQLWADG 1803
4_pfamImport  255 --RNM-------WLSP----------------VLPGQVNL----IYVVFDFPVTISMIKIWNYAKTTSRGVKTVAILVDD 305 
XP_001640011  511 --KHM-------WLAP----------------TFPGQINL----IYVIFDEPKTVSMIKMWNYSKTPIRGAHQFGILVDD 561 
XP_003291217 1650 LLISQGVLQKP 1660
2_pfamImport  317 MHLFSGTLRKA 327 
EEY56508      822 VLIYHGILKQA 832 
EFA83430     2108 LLLFKGKLSPS 2118
Q553C0       2380 LLINQGTLQKP 2390 Dictyostelium discoideum AX4
EFJ29125      618 LLVYKGYVRKA 628 
A0DSF5       1311 YIIYRGYLRQA 1321 Paramecium tetraurelia
XP_004994397 1804 RIMFEGFVHPG 1814
4_pfamImport  306 LLIYNGFLPP- 315 
XP_001640011  562 LLVYHGFLPQV 572 
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