Conserved Protein Domain Family
Spp-24
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pfam07448: Spp-24 
Secreted phosphoprotein 24 (Spp-24) cystatin-like domain
This family represents a conserved region approximately 60 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover.
Links
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Statistics
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PSSM-Id: 429466
Aligned: 13 rows
Threshold Bit Score: 118.376
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_025768298  64 VLDQDSLSMDLEFGIRETTCRRESGEDPSTCDFQRGYYMPAVVCRSTVRMSAEQVRDVWVRCHW 127
Q27967        67 ALDEDSLTMDLEFRIQETTCRRESEADPATCDFQRGYHVPVAVCRSTVRMSAEQVQNVWVRCHW 130 cattle
XP_012903929  72 VLDEDSLNMDLEFGIWETTCRRDSGEDPATCDFQRGYYASPAICRSTVRMSAEQVQGVWVRCHW 135
XP_011221621  72 VLDQDSLNMDLEFGIRETTCRRDSGEDPDSCDFQRGYYVQAAVCRSTVRLSAEEVQDVWVRCRW 135
XP_003278602  69 VLDESNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVPTAVCRSTVKVSAQQVQGVHARCSW 132
XP_012668966  67 ALDENNLVMSLEFSVRETTCRKDSGEDPSTCAFQRSYSVPSAVCRSSVQVSMEQVQSVRARCSW 130
Q62740        67 VLDEDTLVMNLEFTVQETTCLRESG-DPSTCAFQRGYSVPTAACRSTVQMSKGQVKDVWAHCRW 129 Norway rat
XP_003474445  67 VLDEDRVLMSLEFSIRETTCLKDSREDPSTCAFQRGYYVQTAACRSTVQMAGEQAQQVWAHCRW 130
XP_005326459  66 VLDEDNVIMDLEFSIRETTCLRDSGADPSGCAFQRGHYMPAAACRSTVRMSGLQAQEAWAHCRW 129
Q711S8        67 VLGEDSLSMDIEFGIRETTCKRDSGEDPATCDFQRGYFTPSAICRSTVQISAEKVQDVWVRCRW 130 pig
XP_007485973  63 V-NENDLSMDIDFSIRETECRKESGSPPSACDFKRGYYVPTASCRSTVQISAEQVQSAWVRCHH 125
XP_006082742  75 ILGENSSSLDIEFSVRETTCRRDSGADPATCDFQSGYYVPAASCRSTVQMSAEQVQDVWVHCRW 138
XP_003417987  67 V-DGDSLNMDIEFSIRETVCRRDSGEDPSTCDFQRDLYSPAAVCRSSARVSAQQVQDVWVHCRW 129
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