Conserved Protein Domain Family
pyrG

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PRK05380: pyrG 
CTP synthetase; Validated
Statistics
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PSSM-Id: 235437
Aligned: 1095 rows
Threshold Bit Score: 689.065
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
15604245    1 MVRFIFVTGGVVSSLGKGITAASLAMLLQAKGFRVSVRKLDPYLNVDPGTMNPHEHGEVYVTDDGAETDLDLGHYERFTG 80 
189911126   3 KTRYIFITGGVSSSLGKGVTVAALGCLLEARGYTVSLQKMDPYINIDPGTMSPYQHGEVYVTEDGAETDLDLGYYERFTK 82 
183221032   3 KTRYIFITGGVSSSLGKGVTVAALGCLLEARGYTVSLQKMDPYINIDPGTMSPYQHGEVYVTEDGAETDLDLGYYERFTK 82 
288818758   1 MAKFIFVTGGVLSALGKGVTSASIGSLLEEMGYRVTFQKLDPYLNVDPGTMSPYQHGEVYVTEDGAETDLDLGHYERFTF 80 
229221137   2 KQKFIFVTGGVVSSIGKGLTAASLGALLEGRGHKVTIMKFDPYLNVDPGTMSPLQHGEVYVTEDGAETDLDLGHYERFTS 81 
15606537    1 MAKYIFITGGVLSSLGKGITSASIASILEEMGYRVTLQKLDPYLNVDAGTMSPYQHGEVYVTEDGAETDLDLGHYERFTN 80 
188997013   1 MKKYIFITGGVLSSLGKGVTSAAIGSILESMGYKITLMKLDPYLNIDPGTMNPYQHGEVFVTEDGAETDLDLGHYERFTN 80 
195953933   5 NSKFIFVTGGVLSSLGKGVASASIGALLEGLGLSITLQKLDPYLNVDPGTMNPYQHGEVFVTEDGAETDLDLGHYERFTN 84 
225849336   1 MKKYIFITGGVLSSLGKGVTSAAIGSILESMGYKITLMKLDPYLNIDPGTMNPYQHGEVFVTEDGAETDLDLGHYERFTN 80 
289548208   1 MAKFIFVTGGVLSSLGKGVTSAAIASLLEEMGYKVTLQKLDPYLNVDPGTMSPYQHGEVFVTEDGAETDLDLGHYERFTN 80 
15604245   81 VTACKCDNITTGAIYSKLLKDERLGNYTGITVQVIPHVTNIIKDFIMsnt--ngFDFIICEIGGTVGDIEGLPFFEAIRQ 158
189911126  83 SKFSRKNSVSTGQIYHAVIERERKGDYLGRTVQVVPHITNEIRSRIYnltrdqeTDFVIVEIGGTVGDIESIPFLEAIRQ 162
183221032  83 SKFSRKNSVSTGQIYHAVIERERKGDYLGRTVQVVPHITNEIRSRIYnltrdqeTDFVIVEIGGTVGDIESIPFLEAIRQ 162
288818758  81 SRMGRNNNVTAGRVYFNVLERERRGDYLGATVQVIPHITDEIKRLIRsve--gdNHIAIVEVGGTVGDIESLPFLEAIRQ 158
229221137  82 ALMNRSNSVSTGQIYDTVLNRERRGDYLGGTVQVIPHITEEIKARIYeaa--qgSEIILVEIGGTVGDIESQPFLEAIRQ 159
15606537   81 AVMTRDNNVTAGRIYYNVISKERKGDYLGATVQVIPHITEEIKESIKrve--kdNDIVIVEIGGTVGDIEGLPFLEAVRQ 158
188997013  81 AVMTKNNNTTSGRLYFNLLEKERRGAFLGATVQVIPHFTNEIKKSIEkva--enHDITLVEIGGTVGDIESQPFLEAIRQ 158
195953933  85 TNLSKLNNITAGKIYNSVLEKERKGAYLGSTVQVIPHVTDEIKSMILkas--kdKDIAIVEIGGTVGDIESLPFLEAIRQ 162
225849336  81 AVMTKHNNTTSGKLYHNLLEKERRGAFLGATVQVIPHFTNEIKKSIEkva--enHDITLVEIGGTVGDIESLPFLEAIRQ 158
289548208  81 ARMGRWNNVTSGRVYFNVIQRERKGEYLGMTVQVIPHITEEIKRLIRsie--edKDVVVVEIGGTVGDIESLPFLEAVRQ 158
15604245  159 IGNKLKNANCLFIHLTLLPYVKTARELKTKPTQHSVKELRAIGISPNILVCRAERNISKSAIDKIALFCNIKPEYVIPAI 238
189911126 163 MRYEHGNQQVLFLHLTLVPTITAAGEAKTKPTQHSVKELLALGIQPDVLICRINKPMSKEMKNKISLFCNVKEQNVISAV 242
183221032 163 MRYEHGNQQVLFLHLTLVPTITAAGEAKTKPTQHSVKELLALGIQPDVLICRINKPMSKEMKNKISLFCNVKEQNVISAV 242
288818758 159 MSLESKREDVLFIHVTYVPYIKSVGELKTKPTQHSVKELRAIGIQPDMIICRSEFELPKSIKEKISLFTSVSEPSVISAP 238
229221137 160 MRIDVGQENSVLVHVTYVPYIAAAGELKSKPTQHSVKELREIGLQPDFLVCRSEKVIDDNLKAKIGLFCSVKPENVIAAQ 239
15606537  159 LSLELGRKNSMFIHLTYVPYIKAAGELKTKPTQHSVKELRAIGIQPDMIICRADRELPKGIKSKIALFTNVKEEAVISAP 238
188997013 159 MGIENKKEDVIYIHLTYVPYIKVAGELKTKPSQHSVKELRAIGIQPDILIGRAETPLPKEIKKKLSLFTNVDEDSVFSAP 238
195953933 163 LQLEIGKENTLFIHLTYVPYISVAGELKTKPTQHSVKELRAIGIQPDIIICRSEVELPQDVKSKIAMFCNVKPENVISAY 242
225849336 159 MGIENKKEDVMYIHLTYVPYIKVAGELKTKPSQHSVKELRAIGIQPDILIGRSEFPLPKDIKRKLSLFTNVDEDSVFSAP 238
289548208 159 MGLEVGRENAVYIHVTYVPYVKSAGELKTKPTQHSVKELRAIGIQPDVIVCRSEIEIPDSIKEKIALFTNVNKSAVISAP 238
15604245  239 DQ-KNIYLVPIAYHNSGLENKVLNFFNInvvpSKLDKWYDIIDKIKDS-NSKVKIAIITKYHKTQDAYKSVIEALNHAGI 316
189911126 243 DItTSIYEIPLMYREDKLDEVVLNALGMdlrkLNFSQWENMVKKIRNT-KKTVKVALIGKYISLQDAYRSVYESLAHGGI 321
183221032 243 DItTSIYEIPLMYREDKLDEVVLNALGMdlrkLNFSQWENMVKKIRNT-KKTVKVALIGKYISLQDAYRSVYESLAHGGI 321
288818758 239 DV-EYIYEVPIIFKRQGVDRIIAERLGLty-rEVPTKWDRIMETIKNA-NKEIKIGVVGKYIYLKDSYKSLHEALLHGAI 315
229221137 240 DS-RFIYEVPLALHREKLDELIVARLGLsagkLNMKGWQNLVKILGNP-SHTVKIGVVGKYVDLKESYKSLHEALVHGGV 317
15606537  239 DL-EFSYEVPLKLKEQGIDRIITERLNLehreVNLGKWKKIVNVLRNP-EEEVNVALVGKYVELKDSYKSVIEALIHGGI 316
188997013 239 DL-NIIYEIPLYFKKEGLDRAIAKHLNLeykePDLSKWKKIVTVLS-KlEETVDIGIIGKYVDLKDAYKSIHEALIHAQI 316
195953933 243 DV-DYIYKIPLILKAQNLDKIIIDAFRLenkePNLTKWENIVSSLEHL-KDSVDIAIVGKYIKLKDAYKSLIEALIHGGI 320
225849336 239 DL-DIIYEIPLYFKKEGLDKAIAKHLNLeyrePDLSKWKKIVTALS-KlEKEVDIGIVGKYVELKDAYKSINESLIHAQI 316
289548208 239 DV-EFIYEVPIIFRKQDLHRWLTRRLGLef-rEVPSRWDRIVHILKHA-QRKVKVALVGKYVALRDAYKSVVEALTHGGI 315
15604245  317 YYKYKIDVLWINAE--NLTeeniNKKLLDINGILVPGGFGVRATQGKMIAIKYARTNNIPFFGICFGMQLATIEIAQNLI 394
189911126 322 ANDVEVSVVKINPE--DIDskniKELLKGVHGVLVPGGFGERGIEGKIAAIQYARTKNIPFFGICLGMQCAVIEFARNVL 399
183221032 322 ANDVEVSVVKINPE--DIDskniKELLKGVHGVLVPGGFGERGIEGKIAAIQYARTKNIPFFGICLGMQCAVIEFARNVL 399
288818758 316 ANKVKLSIKWINAE--DFD----EKDLTQVDGILVPGGFGERGTEGKIRALRYGREKKIPTFGICLGMQLMCVEFARNVL 389
229221137 318 ANNARVEIIYVDSE--KVTdktvHSLLGKVDGILVPGGFGTRGVEGKITAIKYAREKRVPFFGICFGMQLSAIEFARNVC 395
15606537  317 ANKVKVNVILKNSEqlDIS-----ELQEDIHGIMVPGGFGERGIRGKIEALNFGRENNIPTFGICLGMQLMAIEFARNVL 391
188997013 317 PNKVKVNIHWINSE--KINqenyQEVLKGLDGILVPGGFGDRGIEGKILTAKYARENNIPYFGICLGMQIAVIEFARSVA 394
195953933 321 EHKLKVNMIWVDSE--NLN----EKDLEHVDGILIPGGFGERGIEGKIRALNYGRTKNIPTFGICLGMQLMAVEFARNVL 394
225849336 317 PNKVKINIHWINSE--KINqenyQEMLKGLDGILVPGGFGDRGIEGKILTAKYARENNIPYFGICLGMQIAVIEFARSVA 394
289548208 316 ANDARVEILWINSE--CVR----EEDLKEADGILVPGGFGERGIEGKMLALRFGRVSGKPTFGICLGMQLMCVEFARSVL 389
15604245  395 GIQDAVTEEF---KIKG-TKIIEKINKNCEDatikiknahiskctyseafecdastvytnihedsnnlstdklqietnfr 470
189911126 400 GFKDANSTEF---KPNVqYPVISMIEEQKEI------------------------------------------------- 427
183221032 400 GFKDANSTEF---KPNVqYPVISMIEEQKEI------------------------------------------------- 427
288818758 390 GLQGANSTEF---DPHTpHPVIDLMEEQKSI------------------------------------------------- 417
229221137 396 GIKDATSREFhaeNKRTgNFVIDSMAEQRGV------------------------------------------------- 426
15606537  392 GFSNANSTEF---DPDTpFPVIDIMEEQKKV------------------------------------------------- 419
188997013 395 GLEGANSTEF---NPFTpHPVIDIMPDQKHV------------------------------------------------- 422
195953933 395 GFKDANSTEF---DPNTsNPVIDIMEEQKGI------------------------------------------------- 422
225849336 395 GLEGANSTEF---NPFTpHPVIDIMPDQKNV------------------------------------------------- 422
289548208 390 KLERANSTEF---DPYTpYPVIDLMEDQKNI------------------------------------------------- 417
15604245  471 nmSDIEKTMRLGAYPCNLVANTIAANAYKSLEINERHRHRYKFNNEFQNIFEQHGVVFSGFS-QNkQIVEIIELPELRWF 549
189911126 428 --ERMGGTMRLGAYPCLVKKGSLAHSEYKSDRISERHRHRFEFTLRYKDDFEKKGMNLTGFSpDG-SLAEIVEIPNHPWF 504
183221032 428 --ERMGGTMRLGAYPCLVKKGSLAHSEYKSDRISERHRHRFEFTLRYKDDFEKKGMNLTGFSpDG-SLAEIVEIPNHPWF 504
288818758 418 --DRLGGTMRLGSYPCILLPGSKARDIYGKDMVYERHRHRYEFNNFYREIYENHGVVFSGLSpDG-RLVEIMELKDHPWY 494
229221137 427 --INKGGTMRLGAFPCAIASGSRAYQVYKASSIMERHRHRFEFNNKYKDLFEKNGMMASGIC-KErDLVEIVELPDHPWF 503
15606537  420 --DKLGGTMRLGAYPCKVKENTLAHRIYQKDLIYERHRHRYEFNNRYRKDFESKGVVFSGTSpDD-KLVEIMELKNHMWY 496
188997013 423 --DKKGGTMRLGAYKCHIKKGTKAYEIYKQEEIYERHRHRYEFNPKYVPILEEKGLVVSGIY-KAkNLPEIIELPTHKWF 499
195953933 423 --ENLGGTMRLGAYECLIKENTKAYEIYKENLIYERHRHRYEFNNKYKEHFEKHGFIASGIYpKK-SLVEIIELQNHRWY 499
225849336 423 --DKKGGTMRLGAYKCTLKPGTKAYQIYGQNEISERHRHRYEFNPKYVPILEEKGLVVSGVY-KArNLPEIVEIPNHRWF 499
289548208 418 --EELGGTMRLGAYPCVLAEGSKARAIYGKEIVYERHRHRYEFNNAYRDIFQKEGVVFSGLSpDG-KLVEIIELKDHPWY 494
15604245  550 VGVQFHPEFKSKPFEAHPLFIQFIKATIEYNKSN 583
189911126 505 IGVQFHPEFQSKPTDPHPLFAGFIKAASKLAKKT 538
183221032 505 IGVQFHPEFQSKPTDPHPLFAGFIKAASKLAKKT 538
288818758 495 IGCQFHPEFKSKPFEPHPLFVSFVKACLERKMAF 528
229221137 504 VGVQFHPEFKSKPLAPHPLFVHFVKASLKKK--- 534
15606537  497 LGCQFHPEFKSKPFAPHPLFRDFIRACLEYKRKF 530
188997013 500 IACQFHPEFKSKPFAPHPLFVSFVEAAYKNKQGA 533
195953933 500 IGCQFHPEFKSKPFKAHKLFASFIENAYIYKKER 533
225849336 500 IACQFHPEFKSKPFAPHPLFVSFVEASYKNRLDK 533
289548208 495 IGCQFHPEFKSKPFEPHPLFASFIKACLGD---- 524
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