Conserved Protein Domain Family
TANGO2

?
pfam05742: TANGO2 
Transport and Golgi organization 2
In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.
Statistics
?
PSSM-Id: 461729
Aligned: 103 rows
Threshold Bit Score: 148.945
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_007297583   1 MCIVIAT--TAHp-AYALILLDNRDEFITRP---------TSRPHWWtsHHQHILSSRDLQRaeQGTWLGITRTGNLAVL 68 
Q22009         1 MCITFIKtaKSSldKYKLILLNNRDEQLLRP---------TKEMHWHd----GILSGVDKQEnaRGTWLGLNENGRIGMM 67  Caenorhabditis ...
XP_002637002   1 MCITFFKtaRSSldKYKLILLNNRDEHLLRP---------TREMHWHd----GILSGVDEQDhaRGTWTGINRNGRIGMM 67 
EFP11159       1 MCITFIKtaRSSldKYKLILLNNRDEHLLRP---------TKEMHWHd----EILSGVDEQDeaRGTWTGLTKNGRIGMM 67 
EGT55573       1 MCITFVKtaRSSfdKYKLILLNNRDEQLFRP---------TQEMHWHd----EILSGVDEQNeaRGTWTGLNRNGRIGMM 67 
1_pfamImport   1 MCIGFIKvaKSReeKYKLIILNNRDEDLDRP---------TAPMHWHd----GVLSGVDEQDvaRGTWLGMKREGKIGML 67 
Q9U1Q8         1 MCIGFIKiaTSPseKYKLIILNNRDEDLDRP---------TTPIHWHd----GMLSGVDEKDvaRGTWLGMDAHGKVGML 67  Caenorhabditis ...
EFP13367       1 MCIGFIKvaTSPdeKYKLIILNNRDEDLDRP---------TAPIHWHd----GILSGVDEKDvaRGTWLGIDEHGKVGML 67 
EFH69360       1 MGIIAFDwaENR-----LTVLQNRDEQESRQvvfidlflnVNEAAWL--ENGNILAGLGNPd--GGTWLGCSKTGRVAFL 71 
NP_173496      1 MGIVAFQwgEGE---NILTLLQNRENWQSRS---------IGKAAWe-wDESQVLSGRCAEt--DGTWLGISIRGRVAFL 65 
XP_007297583  69 TN-Y---RETDtsdaQhPVvgaRSR-GGM-----VTAWLtaAVD--ESTDafvrrlmagdgvKGVGG--FSLLCGKLRkr 134
Q22009        68 LS-I---TQTQ----EsKNlhaPSR-GGI-----VNEFLn-ANDtsKMIEslk------kcaSKYNG--FQLVAVEKNst 124 Caenorhabditis ...
XP_002637002  68 LS-I---TQTQ----EsKIpnaPSR-GGI-----VNSFLn-AHNtsDMVEsll------imaGIYNG--FQLVCLEQNqf 124
EFP11159      68 LS-I---TQTQ----EsKDfnaPSR-GGI-----VSSFLk-ANDtsEMMEslk------kdaGKYNG--FQLVGLEQNds 124
EGT55573      68 LS-I---TQTQ----DsKNpdaPSR-GGI-----VNSYLk-AADtsSMMNkla------kdaSMYNG--FQLVALEQNnh 124
1_pfamImport  68 LS-I---TQLA----HtKSkiaPSR-GGI-----VNSYLn-ADRseDVLCslk------enaTNFNG--FQFVGIERNpe 124
Q9U1Q8        68 LS-I---TQPV----DsKHknaPSR-GGI-----VNEYLksGTDttKFYEnlr------enaEKFNG--FQFVGVEKNpt 125 Caenorhabditis ...
EFP13367      68 LS-I---TQPV----DsKHtnaPSR-GGI-----VNEFLksGSDssQFFEnlk------gkaESFNG--FQFVGIERNpk 125
EFH69360      72 LDsIpwpRHPT------------RRgEHL-----TLDFIegTRTpdQFAEdvi------rmqNKGLA--FHLVVADVFgt 126
NP_173496     66 VEag-----------------pVNRdRIIgaecrTLDFLksNLSpeDFADsla------ldsGRNTGiaYHLIVADIVs- 121
XP_007297583 135 rrgregeseresesekemekelePLAIVSNRC-------------EdpenvpWFaer----rgGVYALSNNSYdd----- 192
Q22009       125 g--------------------lyEVRTLANQQ--------------------VDeievcqlkdEYHVVSNSPPt------ 158 Caenorhabditis ...
XP_002637002 125 g--------------------lyEVRTLTNQQ--------------------VEnievcqwndEYHVISNSPPs------ 158
EFP11159     125 g--------------------lyDVKTLTNQQ--------------------VDkievcewndEYHVISNSPLt------ 158
EGT55573     125 g--------------------lyQLQTLTNQQ--------------------VNdisicewddEYHVISNSPPs------ 158
1_pfamImport 125 t-------------------dlfEVKTLTNLL--------------------VDeievekrndACHVYSNSPPh------ 159
Q9U1Q8       126 t-------------------glfHVQSLTNQL--------------------VDqieiskwndKFHVFSNSPPh------ 160 Caenorhabditis ...
EFP13367     126 s-------------------glfEVRSLTNQL--------------------VDqieitkwndKFHVYSNSPPh------ 160
EFH69360     127 ----------------------kSLVYICKKRrdsdhvt------------------kthvpyGVHTITTn--------- 157
NP_173496    122 ----------------------nSMFYIYKPSlsedgmvytepvgP-----------------GVHTLSSAGLdsevghr 162
XP_007297583 193 --pdVWPKVKMGREKVIQAVDALLesgGG-EEE--LV--ERLWE----VLDADTl--PPqkeg---etfEDYI------- 249
Q22009       159 ---kPYQKAVQGKKLLREHLENSD---QFsVDQ--IF--EKLLS----IAKNTTqwyP-----------DAQLqyqtqnv 213 Caenorhabditis ...
XP_002637002 159 ---kPYQKAVYGKQLFSERLQYSD---EMtVDE--VF--ETLLE----IAVNRKqcyP-----------DAQLqfqtrnt 213
EFP11159     159 ---kPYQKAIYGRRLISERLRDSN---EMsVEQ--VF--ENLMS----IATDKTqcyP-----------DAQLqfqtqnt 213
EGT55573     159 ---kPYQKAVHGKRLLRERIQESN---KMtVDQ--IF--DELFV----IATDETqcyP-----------DTQLqfqtqnt 213
1_pfamImport 160 ---iPFKKTEYGKQIFEDSLKCSD---DLnVEQ--IF--EKLLE----IGTDRTscfP-----------DEQIklqtglp 214
Q9U1Q8       161 ---vPFKKTEFGLKMFEEKLKNTD---EMsVEQ--IF--EKLFE----IATCRTscfP-----------DDQIraqtgfp 215 Caenorhabditis ...
EFP13367     161 ---iPFKKAEFGLKIFSESLEKTD---ELdIDE--IQ--RRLFE----IATCRThcfP-----------DDQIrvqtgfp 215
EFH69360     158 ----gIDKGEEVRRKFAAVTEWT-------HSQslELpmELSLRqiilELPNVQrtmNRlqgiktpddhDPID------- 219
NP_173496    163 dlrlK--------RYFSERINREl------PEPisGLaeEVMYDtveaINGDP--------------------------- 201
XP_007297583 250 ---FELRKSIF-----IHpIGsaatppllkpdvvaaadpsiangpslakgdlelkdeerpdpvtaapmtgIYGTQRQTII 321
Q22009       214 eeyNRPLSAIF-----IKyPEgt----------------------------------------------rMYGTRCHTLI 242 Caenorhabditis ...
XP_002637002 214 heyNRPLSAIF-----IKyPEgt----------------------------------------------rEYGTRCHTLI 242
EFP11159     214 deyNQPLSAIF-----IKyPEgt----------------------------------------------rEYGTRCHTLL 242
EGT55573     214 deyNRPLSAIF-----IRyPEgt----------------------------------------------rQYGTRCHTLL 242
1_pfamImport 215 dnfYQPLASIY-----VRyPDe-----------------------------------------------kRYGTRSHTLI 242
Q9U1Q8       216 ehiYKPLTSIF-----VRfPEi-----------------------------------------------rRYGTRSHTLI 243 Caenorhabditis ...
EFP13367     216 gdvYKPLTSIF-----VRfPEs-----------------------------------------------rRYGTRSHTLI 243
EFH69360     220 ------LTSFFkrdgpL-------------------------------------------------------QTNCSTVV 238
NP_173496    202 ------LSSIFvvdtlIEn--------------------------------------------------eHYGTRCTTAL 225
XP_007297583 322 LVDWE----G-KVTFRERSLWD 338
Q22009       243 TVDQK----D-KINILERRLLP 259 Caenorhabditis elegans
XP_002637002 243 TIDQN----N-KVSVLERRYLP 259
EFP11159     243 TINQD----D-HVSILERRFLP 259
EGT55573     243 TIDNE----N-QVSVLERRYLP 259
1_pfamImport 243 AIDNN----G-KVTILERRMIA 259
Q9U1Q8       244 VVDQN----G-QVTVLDRRMEP 260 Caenorhabditis elegans
EFP13367     244 IVDKE----D-NVTVLERRMEA 260
EFH69360     239 VVVPRaaggGgRCIFHEKYMRN 260
NP_173496    226 VVRRT----M-QVRFFERYRAR 242
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap