2Y96


Conserved Protein Domain Family
DUPD1
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cd14575: DUPD1 
dual specificity phosphatase and pro isomerase domain containing 1
Dual specificity phosphatase and pro isomerase domain containing 1 (DUPD1) was initially named as such because computational prediction appeared to encode a protein of 446 amino acids in length that included two catalytic domains: a proline isomerase and a dual specificity phosphatase (DUSP). However, it was subsequently shown that the true open reading frame only encompassed the DUSP domain and the gene product was therefore renamed DUSP27. This is distinct from inactive DUSP27. DUSPs function as protein-serine/threonine phosphatases (EC 3.1.3.16) and protein-tyrosine-phosphatases (EC 3.1.3.48). DUPD1/DUSP27 has been shown to have catalytic activity with preference for phosphotyrosine over phosphothreonine and phosphoserine residues. It associates with the short form of the prolactin (PRL) receptor and plays a role in PRL-mediated MAPK inhibition in ovarian cells.
Links
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Statistics
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PSSM-Id: 350423
Aligned: 6 rows
Threshold Bit Score: 315.226
Created: 30-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
active sitecatalytic site
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 13 residue positions
Conserved feature residue pattern:x x C x x x x x R x x x xClick to see conserved feature residue pattern help
Evidence:
  • Structure:2Y96: Human DUSP27/DUPD1 binds a sulfate ion in the active site; contacts at 4A
  • Comment:primarily based on the structure of human VHR/DUSP3 with bound bisphosphorylated MAP kinase peptide
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          #                                                 #        
2Y96_A     44 FWKGSPQYTHVNEVWPKLYIGDEatALDRYRLQKAgFTHVLNAAHGrw-nVDTGPDYYRDmDIQYHGVEADDLPtfdlSV 122 human
Q29RA3     24 FTHGGVAYTHVNEVWPGVYIGNEetARDRYKLQTLgITHILNAAEGewnsVDTGAEYYKDmQIHYYGVTAEDTPtfniSQ 103 zebrafish
Q4KL92     36 FWHGAPKYTHVNEVWPNLYIGDEktALDRYSLEKNgFTHILNAAHGrw-nVDTGPEYYSDmTVEYYGVEAEDLPsfnlSQ 114 African clawed frog
P0C599     37 WSGPGVQYTHVNQVWPGIYIGDEktALERPGLRDLgITHVLNAAEGkwnnVLTGADYYSDtNIQYYGIEADDKPtfniSQ 116 torafugu
P0C5A2     38 FWKGSAKYTHVNEVWPGIYIGDEt-ARDKATLQRLkITHILNSAHGkf-nINTGANYYKDmLIHYYGIEAFDSPdfnlSV 115 ghost shark
P0C597     37 FWKGCPKYTHVNEVWPNLYIGDEktALDRYSLEKAgFTHILNAAHGqr-nVDTGPEYYQDmTVEYHGVEADDLPtfklSQ 115 chicken

Feature 1                            #######                              ####                
2Y96_A    123 FFYPAAAFIDRALSDdhsKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNRCVLPNRGFLKQLRELDKQLVQQ 202 human
Q29RA3    104 YFYSAAEYIQQTLSDphnKLLLHCVMGRSRSATLFLAFLMLQQRMSLLQAVEQLAHRRHICPNWGFLKQLRELDTHLQEE 183 zebrafish
Q4KL92    115 FFYPAAQFIHKALSTpnsKLLVNCAMGRSRSASLVLAYLMIYKNMTVVESITQVLKHRCILPNRGFLKQLRELDIKLALE 194 African clawed frog
P0C599    117 FFHPAAQFIHEALSQp-hNVLVHCVMGRSRSATLVLAYLMMEHSLSVVDAIEHVRQRRCILPNHGFLKQLRALDITLQEA 195 torafugu
P0C5A2    116 FFYSAAKFIRAGLNTp--KLLVHCAMGRSRSATLVLAYLMIYKNMTVVDAIQEVIQRRCILPNRGFLKQLRTLDIQLAIE 193 ghost shark
P0C597    116 FFYSASEFIDNALQDernKVLVHCAMGRSRSATLVLAYLMIYKNMTVVDAIEQVSRHRCILPNRGFLKQLRELDIELALQ 195 chicken

Feature 1      
2Y96_A    203 R 203 human
Q29RA3    184 R 184 zebrafish
Q4KL92    195 K 195 African clawed frog
P0C599    196 R 196 torafugu
P0C5A2    194 R 194 ghost shark
P0C597    196 R 196 chicken

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