Conserved Protein Domain Family
FH_FOXB2
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cd20043: FH_FOXB2 
Forkhead (FH) domain found in Forkhead box protein B2 (FOXB2) and similar proteins
FOXB2, also called transcription factor FKH-4, may act as a transcription factor. It may also act as a tumor suppressor; it has been found to inhibit the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410817
Aligned: 8 rows
Threshold Bit Score: 211.074
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         #                 ##  #                  ## ##  #      #       
Q5VYV0         1 MPRPGKSSYsDQKPPYSYISLTAMAIQHSaEKMLPLSDIYKFIMERFPYYREHTQRWQNSLRHNLSFNDCFIKIPRRPDQ 80  human
PKU43009      14 RQAAGKSSYsDQKPPYSYISLTAMAIQHSaEKMLPLSDIYKFIMERFPYYREHTQRWQNSLRHNLSFNDCFIKIPRRPDQ 93  Limosa lapponic...
Q8JIT6         1 MPRPGKSSYsEQKPPYSYISLTAMAIQGSqEKMLPLSDIYKFIMDRFPYYRENTQRWQNSLRHNLSFNDCFIKIPRRPDQ 80  African clawed ...
O93529         1 MPRPGRNTYsDQKPPYSYISLTAMAIQGSqEKMLPLSEIYKFIMDRFPYYRENTQRWQNSLRHNLSFNDCFIKIPRRPDQ 80  African clawed ...
XP_005997548   1 MPRPGKNSYsDQKPPYSYISLTAMAIQSSqEKMLPLSDIYKFIMDRFPYYRENTQRWQNSLRHNLSFNDCFIKIPRRPDQ 80  coelacanth
ACE79150       1 MPRPGKDSYgNEKPPYSYISLTAMAIQSSgEKMLPLSDIYKFIMDRFPFYRQNTQRWQNSLRHNLSFNDCFIKIPRRPDQ 80  Florida lancelet
ROI69433       1 MPRPGKNSYsDQKPPYSYISLTAMAIQSSsEKMLPLSDIYKFIMDRFPYYRENTQRWQNSLRHNLSFNDCFIKIPRRPDQ 80  Anabarilius gra...
XP_007903124   1 MPRPGKNSYsDQKPPYSYISLTAMAIQSSsEKMLPLSEIYKFIMDRFPYYRENTQRWQNSLRHNLSFNDCFIKIPRRPDQ 80  elephant shark

Feature 1          ### #                       
Q5VYV0        81 PGKGSFWALHPdCGDMFENGSFLRRRKRFK 110 human
PKU43009      94 PGKGSFWALHPdCGDMFENGSFLRRRKRFK 123 Limosa lapponica baueri
Q8JIT6        81 PGKGSFWALHPnCGDMFENGSFLRRRKRFK 110 African clawed frog
O93529        81 PGKGSFWALHPrCGDMFENGSFLRRRKRFK 110 African clawed frog
XP_005997548  81 PGKGSFWALHPdCGDMFENGSFLRRRKRFK 110 coelacanth
ACE79150      81 PGKGSFWALHPmCGDMFENGSFLRRRKRFK 110 Florida lancelet
ROI69433      81 PGKGSFWALHPdCGDMFENGSFLRRRKRFK 110 Anabarilius grahami
XP_007903124  81 PGKGSFWALHPdCGDMFENGSFLRRRKRFK 110 elephant shark

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