Conserved Protein Domain Family
DUF4678

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pfam15727: DUF4678 
Domain of unknown function (DUF4678)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 318 and 395 amino acids in length.
Statistics
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PSSM-Id: 464827
Aligned: 8 rows
Threshold Bit Score: 438.198
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q53QW1         6 YPLGNVDDSRSKDSPAGEPQGQVPLTADvLAVSSSVASTDWQDIDQASFKTATPRAISTSGDKDKS--AVVPEH------ 77  human
XP_001495270  15 PTPGDVADSGSTDSPTGSSQSQVPLIANvSVASSAAAPAERQDVEQAPIESATSEATSASGDKDEH--EAAAGH------ 86 
XP_852610     12 ASIPTDGNSRSPDGPGAGSQNQVG-----PAANGAIASPEQQDVDQASVDSVTSKPTSASGDQDSY--AVAEGH------ 78 
XP_006906827  12 TSISTHGDSRSSESPTLGSQSQASLRADvPVANGTSASAEWQDVDQASIKPDTSEAVSLPGDKDKH--EDAAEF------ 83 
XP_006082851   9 AGIPTHSDSRSSDSPAVGSQSQVSLPAD-GTAASGAASTERQDVDPASTKSAASKATAASGEENQHedEADAGH------ 81 
ELV09584      22 ASLGDVADGKSPDSSTGGSQSLVPL----PTVSSAAAPA-----GQDSFTTAPSEVASTSGDKDKE--EVAPDK------ 84 
XP_003417918  22 ASLGTVADTQSTDSTAEGSPNQ---------ASSTSAPADQQDVSQASAQPVASEAKSKSGGVPEE-------------- 78 
XP_023366130  19 SPEASLSNSNPADSTIGTSQDEVFPPADvLVSESSPVQTSESSPVQVLESSPVQA--SESSPVQAS--ESSPVQvlessp 94  small-eared galago
Q53QW1        78 -----------GQKtPRKITPLLPSQNPSPLQVSMSLQNPAWDRQVQDARTSQSLVVFPSHLLGKDKMSQMASVPEREPE 146 human
XP_001495270  87 -----------DQE-PKEATALLARPAPEALQISVSPQNAGWGGLVQNLRMTKSSRAFQHDSLGKEKTPQMASIPHREQE 154
XP_852610     79 -----------SQE-PRE--------ASNTLQMSTSPQDPAWDRQGQDSRMIQGLQTSQRDSLAREETPQSAGIPDREQE 138
XP_006906827  84 -----------SQE-PK-----LVHLAPGSLQMSVSLQNQVQDRPVQNARMTQSLQIFQHGSLVNEETPQTAGVLDGEQE 146
XP_006082851  82 -----------SQE-PKEAMAQLAHPAPDARQTSLSLQNLVWAGPVRDSRKTQSLRISHTGSLVKEETPQTAGVPDREQD 149
ELV09584      85 -----------SQEkPREVTALLLRQDPEALKLSTSLQNPEPDRPAPDTRLTQSLVVFSGDPLGNIKTPQTDSVPHSQPE 153
XP_003417918  79 -----------SKR-PKEVKFLLLDQAPVALQASTSLQNTSVVKPVQEAKTSNSQLTLLQHILVKEETPQTQDVPSGKLG 146
XP_023366130  95 vqasesspvqaSQEmLKKMTFLFPRQDSVDLQVSTSLPDQTWDRVVEDSKATHSMVALPHHSLSKEKTPQVEGISNTEPE 174 small-eared galago
Q53QW1       147 SAPSAPSAE-LQSTQHMEAQP-----VESDADhvtagANGQHGPQAASTTKSAEEKAEHPKAPHPEAEALPSDESPVAMG 220 human
XP_001495270 155 LSPTTPSAQ-VWAPQNVEAQP-----AVSTAD-----AFDQLDTGASGVTEAVKEKPDGPKALNADTEALPSAKSHTVTE 223
XP_852610    139 SAPTTPSAE-VQPSRAVDAQP-----VGSGAD-----TARQPRGQDTSATESMEADPERPEPVSLDTEALPGAESQGVTE 207
XP_006906827 147 LALSTPSAV-AQSPQNV---P-----AVSTAD-----ADIQLDTLATGTTEAVVEKPERPEALHPDTEALPSAEFQVVPE 212
XP_006082851 150 LDPSTPRAE-AQFPQNV---P-----AVGTTD-----ADSQLD------TIEAVEKSEGPEAVNPDTEALSSAESQAVTE 209
ELV09584     154 VAASAPKAQ-VWPTE----------------D-----FQGQLDAQASRVTEVAQEGTEGPEASTPDAAALPPSQSKVVTG 211
XP_003417918 147 LTPPTPSAE-TQPTESPAGQPdldtnAVSPATqpaggAKDQPDTQAAGNTETTQEQPGDPEASSP--------------- 210
XP_023366130 175 LAPHASSAEgSVGSESIQSQP-----TVSDTDtssrdTQDQPEPQATSTTKDAEKKSGSPKALCFNTKISSSSDEFQTVT 249 small-eared galago
Q53QW1       221 ANVVDSLGDLQTWFFPPPPAGSVSPSPGPHEVALGRRPLDSSLYTASEENSYMRSMTSLLDRGEGSISSLADILVWSETT 300 human
XP_001495270 224 DDLVARSGDLQPGLLPPSPGGSAPPSPAPHVVALGRRPLDSSLYTASEENNYMRSMTSLLGGGEGSISSLADILVWSETT 303
XP_852610    208 GDLGERSRDLRRPSVAP--GGSGPPSPGPQEVALGGRSLDSSLCMANEEDSYMRSMTSLLGGGEGSISSLADVLVWSETT 285
XP_006906827 213 LDVTHYSGDLQA---PPSPRGSVPPLPGPSIAALG-RPLDSSLYMASGEDNYLHSMTSLLAGGEGSIRSLADVLVWSEDT 288
XP_006082851 210 GDLIDCSRDLQAPPVPPSPGSSATCLPGAPTVALGRRHLDSSLYIACEENAYMRSMTSLLGAGEGSISSLADILVWSEAT 289
ELV09584     212 EDLVGGWQDLQAPSFPPSSEGSASRSPGPQEVALGRRPLDPSLYAAGEEHGYMRSMTSLLGGGEGTISSLADILVWSEGT 291
XP_003417918 211 --LVDSSDEPRAQSFSLSQGCSTPASPALHPVALGRRPLDSNLYMANEENNYMRSMTSLLGGGEGSISSLADILVWSETT 288
XP_023366130 250 EDLV-TSGEWQTPPYYPSPENSVSLLSSPQEVALERTPLDPNLYMASEENNYMRSMTSLLGGGEGSISSLADILVWSETT 328 small-eared galago
Q53QW1       301 MGMaiATGFLDSGHSTVADLLHSSGPSLRSVPSLVGSVSSAFSSGLVSGTSSALRTITRVLETVEQRTVEGIRSAMRYLT 380 human
XP_001495270 304 MGM--ATGFLASGRGSVTDLLYSTGPSLRSISSILGNASAAFSSGLVAGTSSALRSITHMLERVEQRTVEGIHSAVRYLT 381
XP_852610    286 VGM--ASALLASGHSSVTDLLHSPGPSLRSVSSILGS---TFSSGLMAGTSLALRSVTHLLERVEQRTLEGVRSAVRYLT 360
XP_006906827 289 LGM--ATGLLASSRSSVTDLLRSTGPRLRSASSILRNASLVISSGLAAGTNSAMLFIVRMLERAEQRTIEGIRSAVRYLT 366
XP_006082851 290 MSM--ATGLLASRHISVTYLLHSPGLSLRLVSSILGNARLAFSSRLV------LRSVNRMLERMEQRTVEGIRSAICYMT 361
ELV09584     292 MGMgtATGILASGHSSATDLLHGPGPSLRSVSSILESAGSAFSSGLVSGTGSALRSVTHALETVERRTVEGIRSALRYLR 371
XP_003417918 289 MGM--ATGFLGSGHASVTDLLQGTGPSLRSASSILDSASLAFSSGLVAGTGSALRSVTHMLETVERRTIEGIRSAVRFLT 366
XP_023366130 329 MGMgmATGFLASGRDTVADMLHSPGPSLRSVSSILGSASSAFSSGLASGTGSALRSVTHMLETVERRTVEGIRSAMRYLT 408 small-eared galago
Q53QW1       381 SHLTPRQAQADPNY 394 human
XP_001495270 382 SHLTPHWAQAGPNC 395
XP_852610    361 SHLVPHQAHASPNS 374
XP_006906827 367 SHLTPR-------- 372
XP_006082851 362 SQLT----HSGPNA 371
ELV09584     372 SRLPPRRPQAGASC 385
XP_003417918 367 SHLTPPRAPAGPSC 380
XP_023366130 409 SHLTTRRAHAGSNC 422 small-eared galago
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