1G8L,1FC5,1T3E,1UZ5,1XI8


Conserved Protein Domain Family
MoeA

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cd00887: MoeA 
Click on image for an interactive view with Cn3D
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Statistics
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PSSM-Id: 238452
Aligned: 277 rows
Threshold Bit Score: 224.295
Created: 4-Feb-2003
Updated: 9-Sep-2024
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interfaceputative MPTputative
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:1G8L; E. coli MoeA dimer, subunit contacts at 3.5 A
  • Structure:1T3E, dimer of the C-terminal domain of Rattus norvegicus gephyrin, subunit contacts at 3.5 A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                #                                                      
1G8L_A       11 DTALNEMLSRv---tPLTAQETLPLVQcfGRILASDVVSPLDVPGFDNSAMDGYAVRLADiasg----------qplpVA 77  Escherichia coli
CAG37204     19 AKELWSRALTecgfsGRIHSEIIAVDDarGRISAGAVFARRSSPSYNAAAMDGIAVHFTD------------------LS 80  Desulfotalea psy...
ZP_00558515  12 GEALELLSSSw---nPEQEREWVSLKDalGRVTAKPLYSQNTMPVYRISQLDGIAVRSSDfmng-----------ipdTS 77  Desulfitobacteri...
ABB16165     17 FESELLNVNFf----HPREEEIETVLAv-GRITCEPVLAKRSNPHFNASAVDGFAVKAKDtf---------------yAR 76  Carboxydothermus...
ABB40022     18 AVETVRGALDr---eSLVRTQRVASHEaaGRVTAEAVYARFSSPTFHSAAMDGFAVRADDtfaaredaavtlqvqtarTG 94  Desulfovibrio de...
ZP_00884730  14 ARNIIEKILKe---yLSLKTETISVYKahGKFAAKDYLSLNTSPPTDVAAMDGYAINAEQtf---------------nTT 75  Caldicellulosiru...
ABC20428     20 EFLGALRSSGy---lAGLPTEEIDVTQalGRVTAAPVYAAISSPHYPAAAMDGIAVRAETt----------------fGA 80  Moorella thermoa...
YP_502139    12 SEGLRMLQNRf---pFEAGIKTVPVQDsiGLVTAHAIHASLSYPAGHLSAMDGIAVKSGDth---------------gAT 73  Methanospirillum...
YP_503404    11 LAAQRILKTSa---kPRYLIRTIQVTKshGHICHEPVYSRLTVPNSAVSKRDGYVINASDtf---------------nAS 72  Methanospirillum...
YP_503469    14 KEAQKLILSSf---kNQTKSRFIPVKNalGYTLADPVSIFRTIPPVTLAGMDGIALKSKEtr---------------gAS 75  Methanospirillum...
Feature 1                                                                               #       
1G8L_A       78 GKSFAgqpyhgewpaGTCIRIMTGAPVPeGCEAVVMQEQTEQMD------NGVRFTAevr--sgqNIRRRGEDISAGAVV 149 Escherichia coli
CAG37204     81 QASEAaptt---lspEQFSPVNTGNAIKeSYNAVVMIEDVHLRTd-----GQAEVTApat--pwqHIRTIGEDIVATELI 150 Desulfotalea psy...
ZP_00558515  78 GWVKG----------VDYVQADTGDDFPdEFDTVIPVEDTHYDSd-----GRLSLAKgltlkagdCVGAAGTAVRQGDLI 142 Desulfitobacteri...
ABB16165     77 ETSPIllk-----igESCIRVDTGDLIPeGFDAVIMVEDVLYPEp-----GVISVIKpvt--pgtNIRFLGEDFNEEEVL 144 Carboxydothermus...
ABB40022     95 GPLQA----------GHAVAVNTGHPLPeGADAVIMIENVVAALpdstapQSISIEApaf--pwqHVRRIGEDIVATELL 162 Desulfovibrio de...
ZP_00884730  76 DANPAi--------iENFKVVQTGESIE-GFDAVVPFEEAQVEN------GRIKIFQsyy--prqNVRSKGEDVQKEQLL 138 Caldicellulosiru...
ABC20428     81 SEQEPlel----aldREAVVVDTGDPLPeGFDAVIMVEEVAFQDk-----TTAIIKRpav--pgqNVRPVGEDITAGEML 149 Moorella thermoa...
YP_502139    74 DQNPLi--------iTDFVRVNTGNLIPsGYDAVIMIEDTEETD------DGFQIRMpaf--pwqHIRPVGEDIALGEMI 137 Methanospirillum...
YP_503404    73 DSDPVq--------lSVFDQVHTGSPIPeGFDAVVMHEDIREDVn-----GNITILKpar--pgqNIQKAGSEIKTGEMI 137 Methanospirillum...
YP_503469    76 NEHLRe---------VSGISVNIGLPVPdDYDTIISPEEVRKTEk-----GQYLISKpis--prqHIIPKGSEAEKGQII 139 Methanospirillum...
Feature 1              #### #  ## #                                   # #  #                    
1G8L_A      150 FPagTRLTTAELPVIASLGIAEvpvirkVRVALFSTGDElqlpg--qplgdGQIYDTNRLAVHLMLEqlgcEVINLGIIR 227 Escherichia coli
CAG37204    151 IPegQVIRPIDLGAMLAAGVTEievirpPQIKIIPTGTEliqph--enpqaGQIIEFNTRILGGYLEewgaTVQRNLPVQ 228 Desulfotalea psy...
ZP_00558515 143 ADaqVRLTPLHLSMLALSGIYHlevlrkPRVIYIPTGSElitag--irperGQTIESNSLMVTALLEqwgaDVTCYPIIK 220 Desulfitobacteri...
ABB16165    145 LPafAKVKPADIGALLAGGVKTlkvlkkLKALFIPTGDEiipft--etpepGQIPDTNSSFIKAVLAeygyETSIHPIVK 222 Carboxydothermus...
ABB40022    163 FPqgHTLTAYDVGTLLSGGIWEvrvyerIRVRIIPTGDEvldftarpepgpGQVIESNSQVLATLARglgcEVERVAPVP 242 Desulfovibrio de...
ZP_00884730 139 IKkgDLLTIFDKVYLKAGGYLEvevykmPKVAFLPTGEElvdi----vekeGQLVEFNSVIFNDLLQrygfEVGIFKPVE 214 Caldicellulosiru...
ABC20428    150 VPagHSLTPYDLGGLLAAGVTRvtvrprPRVAILPTGTEivppn--pnpapGEILESNGTMLAALVSqwggVPEVYPITP 227 Moorella thermoa...
YP_502139   138 LPggHTIRSGDIGAMASYGISGvdv-lsVRVALIPTGSEivplg--tmpkpGQVIESNMLMAAAEILesgaHVTLYPIVP 214 Methanospirillum...
YP_503404   138 IPadHVISPEDIGAMIGYGITSvqv-kkIVVGLIPTGDElkepc--tapgpGEVIASNCEMLAASLVtigiETFIYPIIP 214 Methanospirillum...
YP_503469   140 MQadHVLTPYDIAALIHFGVKDvav-rhWKVGMIATGDEiipsk--kephpGEIVDTNTIMISGYLQgfgvLTEGFPITP 216 Methanospirillum...
Feature 1                                                                                       
1G8L_A      228 DDpHALRAAFIEADsq-aDVVISSGGVSVGEADYTKTILeelgeIAFWKLAIKPGKPFAFGKlsnsWFCGLPGNPVSATL 306 Escherichia coli
CAG37204    229 DDpKKLREALLAAIae-hDMVIINAGASAGTKDFTSSVIaelgtLIVHGVAIKPGKPVMLGIikgtPVVGLPGYPISALL 307 Desulfotalea psy...
ZP_00558515 221 DKpEELAEALDKALqa-aDLVLINGGSSKGAEDFNTALLrkradLFRHGVRAIPGRPVGMAIiagkPVINMPGPTFATFL 299 Desulfitobacteri...
ABB16165    223 DDpELLYKTVKDNLek-yDVIIINAGSSAGRDDYAAKVIerlgrVLVHGLATKPGKPTVLGIagnkPVIGLPGFPLSAYL 301 Carboxydothermus...
ABB40022    243 DVpEVIRQAVTASLddnvHLTVICAGSSAGSKDYTRATIaalgeVLVHGIAAMPGKPSLLGLckgrLVAGAPGYPVSSVI 322 Desulfovibrio de...
ZP_00884730 215 NNlKKLTEKIKELLqe-fDIVFVNAGSSKGDKDLTVEAIsalgeVLVHGIAIKPGKPTIIGKvenkLVIGLPGFPVSMFF 293 Caldicellulosiru...
ABC20428    228 DDyQLLKERLDRALee-kDLVLINAGSSAGRDDYTARLVeetghLLTHGVATRPGKPVILGIvrdkPVIGVPGYPVSAAL 306 Moorella thermoa...
YP_502139   215 DEpEKIRDAITEAVaf-hDLVLISAGSSKGTKDYTSRIIselgtVFVHGLAIKPAKPVIFGEisgkPVIGMPGYPVACHT 293 Methanospirillum...
YP_503404   215 DDpKKIRDTVEEAVge-cSFVIISGGSSTGCRDHTKDVLtaigtILYHGVAMRPGKTTLAAIvqdiPVFGVPGTPAGALA 293 Methanospirillum...
YP_503469   217 DEpDLIASRILSACdt-cDIVLVLGGTSAGTKDYSVDAIekagnLLFHGVAMEPGKPVLCGSvmgkPVLGMPGSPAACLL 295 Methanospirillum...
Feature 1                               #                                         #             
1G8L_A      307 TFYQLVQPLLaklsgntasglpARQRVRTASRLKktpg-rldFQRGVLqrnadgeleVTTTGhqgSHIFSSFs-lGNCFI 384 Escherichia coli
CAG37204    308 TMRVFVREMVaaflnq-atpqpDYIYATMSRPVHstmg-vdqIVRITLgrvg--dklMATPSgkgAGAVMSFa-rADGLL 382 Desulfotalea psy...
ZP_00558515 300 AMDWCVSGLVhhyygl-papqrPKVKVSLTKALEkrpdyefyFRLMVTgkd---ggyEATPLgwdRNLPDSLl-kMDAIL 374 Desulfitobacteri...
ABB16165    302 VCEIILKPLAekyykn-kfhdyGKIKATLTKTLIsttg-vddFVWGKVsrva--gryCFTPLs-rGASVSSTllkANALL 376 Carboxydothermus...
ABB40022    323 CFEELLAPLIawlgrg-eaprrESVTVEMTRKVPsklg-veeFLRLSVgrvg--ykyMATPLgrgAGCITTLs-rAQAVT 397 Desulfovibrio de...
ZP_00884730 294 VLREIFLRPFfktyn--lnpkeKSIFATLERRLSsdig-seeYVRVSIknid--gknVAKVLkrgASVISSLk-rADGYV 367 Caldicellulosiru...
ABC20428    307 CAELFAKPVLyyrqgi-kpparEQVRAVLGRKIHsplg-reeFVRVRLeweg--drlVATPTsrgAGTIMALa-rADGIV 381 Moorella thermoa...
YP_502139   294 ILREIVRPILiwygl--nvpryQTIEARLAGPLYseig-ideFVLVTTgkik--dtwVALPQsrgSGIQMSLv-rSNGYI 367 Methanospirillum...
YP_503404   294 VLRGLIIPWLsdigy--pvpihHSIPVTLADSVPselg-tddFVLMVVgkvg--deyKAMMVpreGGQISAVk--SNAVL 366 Methanospirillum...
YP_503469   296 SFFQFVFPLLkswgv--pippkKHVIGEITRDIEpffg-ydlFYLVRTryed--gviRIFPLeweFGYITGIs--ADGIL 368 Methanospirillum...
Feature 1                      #    
1G8L_A      385 VLerdrgNVEVGEWVEVEPF 404 Escherichia coli
CAG37204    383 SLptgseGVGAGEPVPIELL 402 Desulfotalea psychrophila LSv54
ZP_00558515 375 IVpigvaGYQAGEEVEVELM 394 Desulfitobacterium hafniense DCB-2
ABB16165    377 RIprfseGYKEGMEIEVTLK 396 Carboxydothermus hydrogenoformans Z-2901
ABB40022    398 RIpanaeGLEQGQSVPAELM 417 Desulfovibrio desulfuricans G20
ZP_00884730 368 TVpinvdLIEEGSLIEVKLI 387 Caldicellulosiruptor saccharolyticus DSM 8903
ABC20428    382 VVprlseGFPAGQEVTVNLL 401 Moorella thermoacetica ATCC 39073
YP_502139   368 TIpasseGFEAGSLVSVKVT 387 Methanospirillum hungatei JF-1
YP_503404   367 HIarnseGIGKGKKSLVHMT 386 Methanospirillum hungatei JF-1
YP_503469   369 HLpewsnGYRKGERVQISLI 388 Methanospirillum hungatei JF-1

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