Conserved Protein Domain Family
pepN

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PRK14015: pepN 
aminopeptidase N; Provisional
Statistics
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PSSM-Id: 237585
Aligned: 417 rows
Threshold Bit Score: 1091.32
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
121608133  12 DGAGPAITIRREDYSAPAFWIDSVDLTFDLDPNKTRVLNRMTLRR--N-PgvAA---Q---PLKLDGQDLNLARVLLDGQ 82  
52841727    8 MKTDQSKVKKLSDYKSLDYFVIHVDLQIDLSKKPVESKARLTVVPn-LnVd--Sh-sN---DLVLDGENMTLVSLQMNDN 80  
54297409    1 MKIDQSKVKKLNDYKVLDYFVIHVDLQIDLGKKPVESKARLTVVPn-PsVd--Sh-sN---DLILDGENMTLVSLQMNDN 73  
54294460    1 MKTDKSKVKKLSDYKSLDYFVIHVDLQIDLSKKPVESKARLTVVPn-PsVd--Sh-pN---DLILDGENMTLVSLQMNDN 73  
183221264   2 TSSSPSPVHKIEEYSPNLWLTPKVDLRFDLDPHLTVVRADYDVQLn-G-----Ns-pG---PLFLHGENLEFLSLRLNGA 71  
146328875   1 --MSTLTITRLNDYRPLAFTVKHHDMKFDLQTDAVIVTHNQEFARsqPkKdeRGfdiEqekNVVLNGEDLQLLDIAIDGK 78  
148241866   1 --MSAEVAVRLSDYQPPLWLVDALELRFELFSAETLVHAQLSIQRs-A----DRq-lE---PLCWPAVAMEIQELAINGM 69  
148359030   1 MKIDQSKVKKLNDYKVLDYFVIHVDLQIDLGKKPVESKARLTVVPn---PsvDSh-sN---DLILDGENMTLVSLQMNDN 73  
289164931   1 -MKNHSGIFRLDDYQVLDYLVKHVDLEIDLSKEPVQSKACLIIEPn-PkSs--Sy-sV---NLELDGENMTLESIALNGK 72  
296107079   1 MKIDQSKVKKLNDYKVLDYFVIHVDLQIDLGKKPVESKARLTVVPn---PsvDSh-sN---DLILDGENMTLVSLQMNDN 73  
121608133  83 CT---SFKMEGQRLVLNHL---PSveehgtaP-FALEIFTTCCPARNTQLMGLYLSQGSFFTQCEAEGFRRITYFLDRPD 155 
52841727   81 LLkenEYELTKDSLIIKNI---PQ-------N-TPFTIEMTSLLGENTDLFGLYETEGVALVKAESEGLRRVFYLPDRPD 149 
54297409   74 LLkehEYELTKDALIIKNI---PQ-------N-TPFTIETTSLLGENTDLFGLYETEGVALVKAESEGLRRVLYLPDRPD 142 
54294460   74 LLkesEYELTKDSLIIKNI---PQ-------N-TPFTIETTSLLGENTDLFGLYETEGVVLVKAESEGLRRVLYLPDRPD 142 
183221264  72 IVdpsEFEIQELGILIYHP---PS-------SkFQLTIENRICPSKNSSLEGLYQSGSMLCTQNEPEGFRKIVYAIDRPD 141 
146328875  79 MLpagKYRYKNDLLTLFDV---PD-------K-FTLTTTVRLDPDNNLQLSGLYRSNGIYCTQCEAEGFRRISFGYDRPD 147 
148241866  70 ALpaeAWSHQGGELVIESAvlpDD-------PsWTLQTRVRLDPASNTSLEGLYVSGGLFTTQCEAEGFRRITPFPDRPD 142 
148359030  74 LLkehEYELTKDALIIKNI---PQ-------N-TPFTIETTSLLGENTDLFGLYETEGVALVKAESEGLRRVLYLPDRPD 142 
289164931  73 ILlpeEYEITKDSLVIKNV---PQ-------G-KTFKLETITRLGKNTDLFGLYETEGTILVKAETEGLRRVLYCHDRPD 141 
296107079  74 LLkehEYELTKDALIIKNI---PQ-------N-TPFTIETTSLLGENTDLFGLYETEGVALVKAESEGLRRVLYLPDRPD 142 
121608133 156 VMASYSVTLRADKALYPVLLSNGNLVASG--ALEDGRHFAKWVDPHKKPCYLFALVAGNLVAREQKIRSRSGREHLLQVY 233 
52841727  150 NLATYKTTIIANQEDYPVLLSNGVLIEKK--ELPLGLHSVTWLDDVPKPSYLFALVAGNLQRSVTYYQTKSGRELPIEFY 227 
54297409  143 NLATYKTTIIANQEDYPVLLSNGVLIEKK--ELPLGLHSATWLDDVPKPSYLFALVAGNLQRSVTYYQTKSGRELPIEFY 220 
54294460  143 NLATYKTTIIANQQDYPVLLSNGVLIEKK--ELPLGLHSATWLDDVPKPSYLFALVAGNLQRSVTYYQTKSGRELPIEFY 220 
183221264 142 NMMQFVVTISGDPSLFPVMLSNGNLVYEKilS--DGKKEVKWEDPFPKPSYLFALVAGELVETIDSFQTKSGRNVTLKIF 219 
146328875 148 ALATYRVSIEADKTANPVLLSNGNLEASG--DLNEGRHYATWFDPHPKPSYLFALVAGDLAVNAKRFTTTKGKEVELRIY 225 
148241866 143 VLSRYRVRIEADQNDCPVLLSNGNCAATGnlSGG--RHFAEWHDPFPKPSYLFALVAGRLQEVRDQFTTASGREVALRIH 220 
148359030 143 NLATYKTTIIANQEDYPVLLSNGVLIEKK--ELPLGLHSVTWLDDVPKPSYLFALVAGNLQRSVTYYQTKSGRELPIEFY 220 
289164931 142 NLATYKTTIIAKKIDYPILLSNGTLIEQK--DLNDELHSVTWFDKVPKPSYLFALVAGKLQKSVTYFKTRSERMLPIEFY 219 
296107079 143 NLATYKTTIIANQEDYPVLLSNGVLIEKK--ELPLGLHSVTWLDDVPKPSYLFALVAGNLQRSVTYYQTKSGRELPIEFY 220 
121608133 234 VRPGDLDKTEHALQALVHSVAWDEARFGLPLDLERFMIVATSDFNMGAMENKGLNIFNTKYVLASEATATDSDFANIESV 313 
52841727  228 VPPSATSKCDFAKEVLKEAMAWDERTFNLECALRQHMVAGVDKYASGASEPTGLNLFNTENLFASPETKTDLGILRVLEV 307 
54297409  221 VPPSATAKCDFAKEVLKEAMAWDERTFNLECALRQHMVAGVDKYASGASEPTGLNLFNTENLFATPETKTDLGILRVLEV 300 
54294460  221 VPPSATSKCDFAKEVLKEAMAWDERTFNLECALRQHMVAGVDKYASGASEPTGLNLFNTENLFATPETKTDLGILRVLEV 300 
183221264 220 VEKGNEKKVSFAFESLKKAMKWDEDTFGLEYDLDLFMIVAVEDFNMGAMENKGLNLFNAKLVLADKKSATDETFESILAV 299 
146328875 226 TEAAFIDQTDYALQSLIDAFNWDETRFNLSYDLDRFNLVAISDFNMGAMENKSLNIFNTKFVLANTETAADSDFRAIQRV 305 
148241866 221 VEPGDEHLCGHAMASLKRSMAWDEQAFGLEYDLDEFNLVAVRHFNMGAMENKSLNIFNSKLVLADSETATDAELERIESV 300 
148359030 221 VPPSATAKCDFAKEVLKEAMAWDERTFNLECALRQHMVAGVDKYASGASEPTGLNLFNTENLFASPETKTDLGILRVLEV 300 
289164931 220 VPPQATTKCDFAKEALKEAMRWEENIFNLECDLPQHMVAGVDKYASGASEPTGLNLFNTANLFATPETRTDNDILRVLEV 299 
296107079 221 VPPSATAKCDFAKEVLKEAMAWDERTFNLECALRQHMVAGVDKYASGASEPTGLNLFNTENLFASPETKTDLGILRVLEV 300 
121608133 314 VGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSQDLAdspsARAVKRIEDVRVLRTTQFPEDAGPMAHPVRPDSYI 393 
52841727  308 VAHEFFHYWSGDRVTIRDWFNLPLKEGLTTFRAAMFREELF---------GTDLIRLLDGKNLDERAP------RQSAYT 372 
54297409  301 VAHEFFHYWSGDRVTIRDWFNLPLKEGLTTFRAAMFREELF---------GTDLIRLLDGKNLDERAP------RQSAYT 365 
54294460  301 VAHEFFHYWSGDRVTIRDWFNLPLKEGLTTFRAAMFREELF---------GTDLIRLLDGKNLDERAP------RQSAYT 365 
183221264 300 IGHEYFHNWTGNRVTLRNWFNLTLKEGLTVFRDQWFTEDMT----DPAVKRIKDILFLKEHQFPEDQGPMSHPIVPKSYT 375 
146328875 306 IGHEYFHNWTGNRITCRDWFQLTLKEGLTVFRDQEFSSDLN----ERTIKRIEDVELLRREQFAEDGGPMSHPVQPQEYA 381 
148241866 301 IGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFTSDLH----GAALKRIEDVSMLRAAQFPEDAGPTAHPVQPSEYI 376 
148359030 301 VAHEFFHYWSGDRVTIRDWFNLPLKEGLTTFRAAMFREELF---------GTDLIRLLDGKNLDERAP------RQSAYT 365 
289164931 300 VAHEYFHYWSGDRVTIRDWFNLPFKEGLTTFRAAMLREHLF----GSDLIRILDGKNL------DERAP-----RQDTYT 364 
296107079 301 VAHEFFHYWSGDRVTIRDWFNLPLKEGLTTFRAAMFREELF---------GTDLIRLLDGKNLDERAP------RQSAYT 365 
121608133 394 EINNFYTVTIYEKGAELVRMMHTLVGRAGFARGMKLYFERHDGQAVTCDDFAQAIADAnpasdLARLLPQFKRWYSQAGT 473 
52841727  373 AVRSLYTAAAYEKSADIFRMMMLFIGKEPFIEAVAKFFKDNDGGAVTLEDFIESISNS-----SGKDLRSFLSWFTESGI 447 
54297409  366 AVRSLYTAAAYEKSADIFRMMMLFIGKKTFIQGVAKFFKDNDGSAVTLEDFIDSLSNS-----SGKDLRSFLSWFTESGI 440 
54294460  366 AVRSLYTAAAYEKSADIFRMMMLFVGKESFFQGVAKFFKDNDGGAVTLEDFIDSLSHS-----SDKDLYSFLSWFTESGI 440 
183221264 376 EMNNFYTVTVYEKGAEVIRLVSEILGRETFKKGLMDYLTRYDGQGVTFEEFISSMEAA-----FGKPIPNIRNWYHRSGT 450 
146328875 382 AIDNFYTRTVYEKGAELIRMYHTIIGEEKFQKGMALYIERHDGQAVCIQDFAQCMEDAsdy----pftKQFFDWYTTSGT 457 
148241866 377 AIDNFYTTTIYEKGAELIRMQRTLLGPEAFLKGVQLYLRRHDGQAATCEQFVQALEEA-----SGVSLQTFRRWYHQAGT 451 
148359030 366 AVRSLYTAAAYEKSADIFRMMMLFIGKEPIIQGVAKFFKDNDGGAVTLEDFIESISTS-----SGKDLRSFLPWFTESGI 440 
289164931 365 NVRSLYTPAAYEKSADIFRMIMLSLGEKDFYAGMTQFLKDHDGEAVTLENVLDSLSTF-----TAKDIHRFLKWFTESGI 439 
296107079 366 AVRSLYTAAAYEKSADIFRMMMLFIGKEPIIQGVAKFFKDNDGGAVTLEDFIESISTS-----SGKDLRSFLPWFTESGI 440 
121608133 474 PCVHASGSYDAASGSYTLTLRQSCAPTPDQADKQPFVIPVELGLLSASGAALPLHLAGAdstdsapasaptSRLVVLTEA 553 
52841727  448 PELIVTDELNPDTKQYFLKIKTV--------NGRNRPIPILMGLLDSSGAEIVA-----------------DKLLIVDQE 502 
54297409  441 PELIVTDEFNPDAKQYLLKIKIA--------NGKNRPVPFLMGLLDSSGKEIVA-----------------DTLLMVDQE 495 
54294460  441 PELIVTDEFNPDTKQYLLKIKTV--------NGKNRPIPVLMGLLDSTGKEIVA-----------------DKLLILDQE 495 
183221264 451 PKLQVKETYDPKSNEWEFSIKDSSQ------KDLPLIFVNSYACFDSNGTLLA------------------EGKRIQEGH 506 
146328875 458 PKVKFTASYNKTEGSFTLSAHQN--ISAVNP-KRPLVIPIRFSLISPNGRLYRFEDGSE------------SQLLLLDKE 522 
148241866 452 PQLCLQTHWDGAAGELKLTLSQLTPPTPGQSDKQPVPIPVRLGVLDAAGQQLQ------------------ERLLVLEQA 513 
148359030 441 PELIVTDELNPDTKQYFLKIKTA--------NRKNRPIPILMGLLDSSGTEIVA-----------------DTLLMVDQE 495 
289164931 440 PQVTVTDAYNAETKRYTLKFETR--------ENKERPIPVVVGLLNNDGAEILN-----------------DTLITVDEP 494 
296107079 441 PELIVTDELNPDTKQYFLKIKTA--------NRKNRPIPILMGLLDSSGTEIVA-----------------DTLLMVDQE 495 
121608133 554 EQTLTFTGL---GSAPVPSLLRNFSAPVVLDIETTDDQLLTLLEHDTDAFNRWEAGQRLMLRCAIDAIADGaneaGASSh 630 
52841727  503 EIEFQFENI---QTRPIPSLLRSFSAPVHMKYEYSYQDLLLLMQFDTNLYNRCEAAKQLISALINDFCI------GKKI- 572 
54297409  496 EIEFQFENI---QTRPIPSLLRSFSAPVQMNYEYSYQDLLLLMQFDTNLYNRCEAAKRLISVLINDFCI------GKKI- 565 
54294460  496 EIEFQFENI---QTRPIPSLLRSFSAPVHMKYEYSYQDLLLLMQFDTNLYNRCEAAKQLISALLNDFCK------GKKI- 565 
183221264 507 EDQIRMRAIdpsGNKPIVSFFRGLSSPILLETKLAKEEIRVLAENEPDGVSRFFNFQNLIFLWMEESIRS-----GKSE- 580 
146328875 523 RGSWTFTHA---DADLIPVLMQGFSAPIYYEYDYGDDELIALAQFAPDGFARYEAVQTLLHRMFQLSLKDSr--aLKDL- 596 
148241866 514 EQSWTLSGLptgPKPPVLSLLREFTAPVQLEFPRSDADLALLLRSDPDPFSRWDAGQQLWQQQLLQPNPA---------- 583 
148359030 496 EIEFQFENI---QTRPIPSLLRSFSAPVHMKYDYSYQNLLLLMQFDTNLYNRCEAAKQLISALLNDFCIG------KKI- 565 
289164931 495 EMEFHFDNI---NAHPTPSLLRSFSAPIILEFTYSTEQLLLLMQHDTNFYNRCEAAKKLITRLVSDYCL------GKSM- 564 
296107079 496 EIEFQFENI---QTRPIPSLLRSFSAPVHMKYDYSYQNLLLLMQFDTNLYNRCEAAKQLISALLNDFCIG------KKI- 565 
121608133 631 ighighkVLSADLIQAMRSVLRH---P--TL-APAFKELVLTLPSESYIAEQL----DVVDPQRIHAVRQAMHEQLALSL 700 
52841727  573 -------ELSPQFFAVYKALLSD---N--SL-NEWMLAELITLPSLEELIENQ----DKPDFEKLNEGRQLIQNALANEL 635 
54297409  566 -------ELSPQFFAVYKALLSD---N--SL-NEWMLAELITLPSLEELIENQ----DKPDFEKLNEGRQLIQNALANEL 628 
54294460  566 -------ELSPQFFAVYKALLSD---N--SL-NEWMLAELITLPSLEELIENQ----DKPDFEKLNEGRQLIQNALANEL 628 
183221264 581 -------DL-TRLLETLGSGF-----K--KDwDKTYFSFYLTFPSLNQISEQL----QCFDFLKMETLRKEAIRNIATKF 641 
146328875 597 ---------SEKVSNLMAFLLKN---K--KI-SDSEKALLLAVPPLSSFLPTLp---APINMDNVLSAYDRVVRTIALKM 658 
148241866 584 ---------TAELLESVCSQLLQavvS--GSsDPRLVWALLQAPSRPELEAACmaagTTPDPLELERSLLQRRCWLGEAL 652 
148359030 566 -------ELSPQFFAVYKALLSD---N--SL-NEWMLAELITLPSLEELIENQ----DKPDFEKLNEGRQLIQNALANEL 628 
289164931 565 -------ILESQFFQVYRNLLNE---SthSL-NYWLLAELLTIPSEEILFAEL----QNQDFEKISQARQLIQNQLATEL 629 
296107079 566 -------ELSPQFFAVYKALLSD---N--SL-NEWMLAELITLPSLEELIENQ----DKPDFEKLNEGRQLIQNALANEL 628 
121608133 701 HSDW--AWAW----EQHQDSD--RYRPDAPSAGRRALSGLALHMLCC--AARHQGAPLwpgkAYQRLKSA--ANMTERLN 768 
52841727  636 KTDF--YNLLfriqISGDDDKqkLKGFDLKQAGLRRLKSVCFSYLLN--VDFEKTKEK----LILQFEDAlgKNMTETAL 707 
54297409  629 KTDF--YNLLfriqISGDDDKqkLKGFDLKQAGLRRLKSVCFSYLLN--VDFEKTKEKlilqFEDALG----KNMTETAL 700 
54294460  629 KTDF--YNLLfriqISGDDDKqkLKGFDLKQAGLRRLKSVCFSYLLN--VDFEKTKEKlilqFEDALG----KNMTETAL 700 
183221264 642 TKEF--QILYeenrKTIPIQT-------KEEIGKRRLKNTALYYLLH--DPSHRFEGL----AVAQQREA--KHMSEEIS 704 
146328875 659 RRNW--SDFL----KAGKPET--QAKYSVKDAGIRALYGLAMKIMST--FDDESNRKL----FLELYKNA--DCMTDRMN 722 
148241866 653 QAELkaVIAW----AEPQADQ--SW---PAGVGARAMLALAWSWLSAagDGAVRQQA-----ARAVDG----GSMSLARS 714 
148359030 629 KTDF--YNLLfriqISGDDDKqkLKGFDLKQAGLRRLKSVCFSYLLN--VDFEKTKEKlilqFEDALG----KNMTETAL 700 
289164931 630 KEDL--LRAQkkpaGLPIPGNapFKSFDIFAAGIRRLKHVYHEYLLS--VQPEKTEQE----LVEQFNNSlgKNMTDCMS 701 
296107079 629 KTDF--YNLLfriqISGDDDKqkLKGFDLKQAGLRRLKSVCFSYLLN--VDFEKTKEKlilqFEDALG----KNMTETAL 700 
121608133 769 ALSALVA--NGSELAAPALARFHALFKDEPLVIDKWFALQAGTPDRAgnRLSAVRQLMQHPDFSLKNPNRARSVIFSYCC 846 
52841727  708 ALSMLCEinCEEA--DVALEDYYHYWKNDPGAVNNWFSIQALAHSPD--VIERVKKLMRHGDFDLSNPNKVYALLGSF-I 782 
54297409  701 ALSMLCEinCEEA--DVALEDYYHYWKNDPGAVNNWFSIQALAHSPD--VIERVKKLMRHSDFDLSNPNKVYALIGSF-I 775 
54294460  701 ALSMLCEinCEEA--DVALEDYYHYWKNDPGAVNNWFSIQALAHSPD--VIERVKKLMRHGDFDLSNPNKVYALLGSF-I 775 
183221264 705 ALRYLIE--IGSKEKENGISLFYDRWKEDALVLDVWFAAQVG-TGEN--RFEELEILETHPKFFIKNPNKVRSLYFSF-A 778 
146328875 723 ALEALNA--HADRYREEALQDFYQRFADQPLVIDKWFMLQSKDNIAG--ALERIEALTRLPAFQIRNPNRFRALVFTFMQ 798 
148241866 715 GLAALQP--WDCPERQQASLAFAKRWRQRPVILDAWFGMEASAPFGD--GITRADALLEDPAFDPNAPNSLRAVLGGF-G 789 
148359030 701 ALSMLCE--INCEEADVALEDYYHYWKNDPGAVNNWFSIQASAHSPD--VIERVKKLMCHGDFDLSNPNKVYALLGSF-I 775 
289164931 702 ALNLLLQ--HNSSKSDLLLEHYYHYWQDDVSAVNYWFNVQAAAHTKN--VGKNVTQLMSHPAFDLSNPNKVNALLGTF-I 776 
296107079 701 ALSMLCE--INCEEADVALEDYYHYWKNDPGAVNNWFSIQASAHSPD--VIERVKKLMCHGDFDLSNPNKVYALLGSF-I 775 
121608133 847 ANPSAFHRADAAGYVFWSERVIELDALNPQVAARLARALERWKKLAQPWRSAAREAIARVAAKPELSSDVREVVNRALA 925 
52841727  783 KNPFGFHSVTGEGYQLVADAIFDLDKINPTLAANLTEKFTYWDKYDVNRQAMMISTLKIIYSNAT-SSDVRTMAKKGLD 860 
54297409  776 KNPFGFHSVTGEGYQLVADAILDLDEINPTLAANLTEKFTYWDKYDVNRQAMMISTLKIIYSNAT-SSDVRTMAKKGLD 853 
54294460  776 KNPFGFHSITGEGYQLVADAILDLDKINPTLAANLTEKFTYWDKYDVNRQAMMISTLKIIYSNAT-SSDVRTMAKKGLD 853 
183221264 779 RNPLSFHSKSGKGYQIIAERIKQLNVINPQIAAGLAKLFSSASKQNGDLPRIAKRELEDIQNLPNLSKDLGEVVGKIIN 857 
146328875 799 SNPKLFHRADGSGYHFVIEQIRRIIRDNPQLSARMIRGLEIVTKLDAKRKALAHKELSSLLEMEDISVDAREIIERVSA 877 
148241866 790 RCAEHFHRSDGRGYQWMAQQLVAVDQRNPIAASRMLKLFMGWRRYSPERQQLMRSSLEWLAENLT-SPNSKEVVMLCLG 867 
148359030 776 KNPFGFHSVTGEGYQLVADAILDLDRINPTLAANLTEKFTYWDKYDVNRQAMMISSLKLIYSNAT-SSDVRTMAKKGLD 853 
289164931 777 KNPYGFHASSGEGYQLIVDVILQLEKINPTLAANLTEKFNNWDKYNEKRQKLILHQLEFLSAH-ALTTDVRNMAKKGLD 854 
296107079 776 KNPFGFHSVTGEGYQLVADAILDLDRINPTLAANLTEKFTYWDKYDVNRQAMMISSLKLIYSNAT-SSDVRTMAKKGLD 853 
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