2JAM


Conserved Protein Domain Family
STKc_CaMKI_gamma

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cd14166: STKc_CaMKI_gamma 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 271068
Aligned: 4 rows
Threshold Bit Score: 610.842
Created: 16-Oct-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:2JAM: Human CaMKI-gamma binds inhibitor J60; contacts at 4A.
  • Comment:also based on structures of other members of the CAMK family bound with ATP or ATP analogs or inhibitors
  • Citation:PMID 9362479

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  ####    #            # #                            #               ##
2JAM_A         7 IRKTFIFMEVLGSGAFSEVFLVKQRlTGKLFALKCIKKSpafrDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQ 86  human
AAH59490      17 IKEIFDFKEVLGSGSFSEVYLVRERkSGNFYALKCVKKKql-hHSNLENEIQVLKRIKHSNVVGLEDFYESRTHYYLVME 95  zebrafish
XP_417986     19 IRKTFIFMEALGSGAFSEVFLVKQRsTGKLFALKCIKKSpltrDSSLENEIAVLKKIKHENIVTLEDIYESTTHFYLVMQ 98  chicken
XP_002933582  40 IRETFVFMEVLGSGAFSEVYLVKHRsTGQHYALKCIKKVnssrDKSLENEIAVLKRIKHENIVTLEDIYESSSHFYLVMQ 119 western clawed ...
Feature 1        ##   #                                          ## #            ##              
2JAM_A        87 LVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLtpEENSKIMITDFGLSKMEQNGIMST 166 human
AAH59490      96 LVSGGELFDRILDRGVYTEKDASRVINQVLEAVSYLHQNSIVHRDLKPENLLYYspDENAKIMISDFGLSKMSDHGVMST 175 zebrafish
XP_417986     99 LVSGGELFDRILERGVYTEKDASVVIHQVLTAVKYLHENGIVHRDLKPENLLYLtpEENSKIMITDFGLSKMEQNGIMST 178 chicken
XP_002933582 120 LVSGGELFDRILERGVYTEKDASNVIRQVLSAVKYLHDNGIVHRDLKPENLLYLtpDENSKIMITDFGLSKMEENGIMST 199 western clawed ...
Feature 1                                                                                        
2JAM_A       167 ACGTPGYVAPEVLAQkPYSKAVDCWSIGVITYILLCGYPPFYEEtESKLFEKIKEGYYEFESPFWDDISESAKDFICHLL 246 human
AAH59490     176 ACGTPGYVAPEVLAQkPYSKAVDCWSIGVITYILLSGYPPFYEEnETRLFSKIMKAEYAFHSPYWDDISESAKDFIRHML 255 zebrafish
XP_417986    179 ACGTPGYVAPEVLAQkPYSKAVDCWSIGVITYILLCGYPPFYEEtESKLFEKIKEGYYEFESPFWDDISDSAKDFIRHLL 258 chicken
XP_002933582 200 ACGTPGYVAPEVLAQkPYSKAVDCWSIGVITYILLCGYPPFYEEtESRLFEKIREGAYEFESPFWDDISKSAKDFISCLL 279 western clawed ...
Feature 1                                                     
2JAM_A       247 EKDPNERYTCEKALSHPWIDgNTALHRDIYPSVSLQIQKNFAKSK 291 human
AAH59490     256 EKNPSKRYTTEQALSHPWIIgDTAHNDNIIHSVCEQIQKNFAKSK 300 zebrafish
XP_417986    259 EKNPDTRFSCEEALRHPWINgNTALHRDIYPSVSAQIQKNFAKSK 303 chicken
XP_002933582 280 EKDSKKRYNCEKALKHPWIAgNTALHRDIYRSVSIQIKKNFAKSK 324 western clawed frog

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