Conserved Protein Domain Family
NICE-3

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pfam07406: NICE-3 
NICE-3 protein
This family consists of several eukaryotic NICE-3 and related proteins. The gene coding for NICE-3 is part of the epidermal differentiation complex (EDC) which comprises a large number of genes that are of crucial importance for the maturation of the human epidermis. The function of NICE-3 is unknown.
Statistics
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PSSM-Id: 462157
Aligned: 23 rows
Threshold Bit Score: 174.754
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001949034   3 QQLSGVTVVIFIAGGILTFILLFIFAKRQIMRFAlr-sRRGPHVPIGHDGKKTLKREIERRIEVVPKIAFEPKLMTIDqd 81 
EKC29150       5 RELTIVGVVLFIAAGLLLFIMAFIVVKRQISRFA----TRGAQKSIGSGAPKMFKKQILEKLNRVSTIKYEPILLNNKvm 80 
XP_001637825  18 KKFGGVGLVMTIVFTIAIGLMIVIIVKRQILRMIli-sRRGPHTSIGADAPRPLARQIENQLKRISHLRIEPRMMSEQfn 96 
XP_003141371   1 mvidGYSVLFLFTVGVLITIILAIFVQRQIFRMRdnsvRREANIVVGAGLSKRKKEELDRGIEIVRQFQ----LLR---- 72 
EFX67776       3 SDFSGATIVIFIALGSLVLVLLFIFAKRQIMRFTlr-sRRGPHVPIGHSAPRWLRKEIERRLDLVGRIKHEPKLVSEAss 81 
XP_001600008   3 QQLSGVNIVLFIAAGVQTVILLFIFAKRQIMRFTlr-sRRGPHTPIAYDTIKSLRKEIDRRIHVIPRIQYEPYL------ 75 
EFA06714      16 EELSGVTVVIIIGLGVLTFILLFIFAKRQIMRFAlr-sRRGPHVPIGHDGPKVLKREIERRIDVIPRIICDPQLISKKd- 93 
1_pfamImport   1 EKLSGVMVVIIIAGGVLTFILLFIFAKRQIMRFAlr-sRRGPHVPVGHGAKKALKKEIHRRIELVPKIVYEPRVSDESn- 78 
EDW32322      28 EQLSGVMIIIIISGGVLTSLMLFIFAKRQIMRFQlr-gRRGPHVPVGNDAKKVLRREIERRLDCIQKIAQEPKLLWTDg- 105
5_pfamImport   1 --WTGINLLLVLIYGFITVLLVAIFAKRMIHRVSlk-fSHSVEVE-GSGANKSLKLEIRTRMEEAINFAYEPTLLNPG-- 74 
XP_001949034  82 ddlSKYilpppesnnkpllSHHYRMKAVDDVKKL-EREITKQD-KTLTRHPSENIRSFLLNTL---AVLLDGSGQHIVHQ 156
EKC29150      81 sspDSS-------------HYLHRMKAMDAFSMF-DETIKTVDsNYKGRHPNTRVRWYLTGLS---KTYLCTCPLDLIND 143
XP_001637825  97 rpaDESsfdspp--dqysrSYKYRMKAMDKMGEL-DDLICSVS-HKYNRRKGQPVRSYLKMLQ---QQQVIKKGDDTIDK 169
XP_003141371  73 ---APKfteigtiaehagaPYINRMIAMDELREI-ERQLEFIN-GDLGRVAGESMYAYLSRIR---QIALPSLSEHLCER 144
EFX67776      82 ad-------------thnpETLCRMQAMDDIKIL-EIQLQAAD-PKAGRMPNENLRPFLMAQI---PGILKGCHPKTIHQ 143
XP_001600008  76 ---DESihklmn--egpipSHFYRLKAVNDFKKLgELQINHQN-NFFKRHPKENIRGYLINAL---SDNLTGNGQHMIHE 146
EFA06714      94 ---PRYivypg----qqipAHYYRLKAVDDVKTL-ESEITRQD-SAFYRHPSENLRAYLLTTL---AAPLNGSGQRLIHQ 161
1_pfamImport  79 ---SKYilppg----ssvpPFYYRLKACDDVKLL-EKEICRQDiTSAGRHPSESLRAYLLNNL---ASPLGGPGSRLIHQ 147
EDW32322     106 ---DKYivppeq--eeplpPYYYRMKAVDDVKLL-ESEIARAD--GSSRHAHESLRAFLLTTL---SIPLTGAGQRMIHQ 174
5_pfamImport  75 ---DDRlnmdv---kpghfYFVNRMKTVDGFRNI-DQVLGDLN-KDLYRPKGKNVRQHLFDAKshsSGCLRAVRTNQLQA 146
XP_001949034 157 FCDLYEHARYDPNEFLDEEYQSFIRLMKKLID 188
EKC29150     144 FCDAYEHARHSPEMFGENEYNNYMKLLTRLLD 175
XP_001637825 170 LADMYEHARFEPKEFGNIQYKKFAYLVEQLKD 201
XP_003141371 145 IGLVAEHCRYRHEPFGESELTETRMLIKEIVk 176
EFX67776     144 LCDLYERARFSPDGFTSNHLETYRELVASLVr 175
XP_001600008 147 FCDLYEHARHDPSEFQDEEYEIYSKLLLKLID 178
EFA06714     162 FCDLYEHARHDPNPFGDEEYQQYNRLLMKLID 193
1_pfamImport 148 FCDLYEHARHDPADFADDEYHVYSRILLKLID 179
EDW32322     175 YCDMYEHARHDPNEFGKDEYEAYHHLLLKLME 206
5_pfamImport 147 LADFYLQARFGTEPYHFEDHLKFL-------- 170
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