Conserved Protein Domain Family
bHLH_TCFL5
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cd18909: bHLH_TCFL5 
basic helix-loop-helix (bHLH) domain found in transcription factor-like 5 protein (TCFL5) and similar proteins
TCFL5, also termed Cha transcription factor, or HPV-16 E2-binding protein 1 (E2BP-1), is a bHLH transcription factor that plays a crucial role in spermatogenesis. It regulates cell proliferation or differentiation of cells through binding to a specific DNA sequence like other bHLH molecules.
Links
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Statistics
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PSSM-Id: 381479
Aligned: 6 rows
Threshold Bit Score: 102.324
Created: 24-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Saccharomyces cerevisiae bHLH domain of PHO4 (1AOA) binds DNA.
  • Citation:PMID 9303313
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ######  ## ##                     ##                       
Q9UL49       400 QRRERHNRMERDRRRRIRICCDELNLLVPFCnaETDKATTLQWTTAFLKYIQERHGDSLK 459 human
XP_002943245 350 QRREKHNRMERDRRRRIRVSCDELNLLVPFCdgDTDKATTLQWTAAFLRYLRGKHGDSLK 409 western clawed frog
AWP10251     440 LRREQHNSLERERRKRIRLFCDELNALVPFCdaSTDRVTTLHWTTAFLRFISKMFGDALK 499 turbot
XP_001234727 405 QRRERHNRMERDRRRRIRICCDELNLLVPFCtaDTDKATTLQWTTAFLKYIQEKHGDSLK 464 chicken
XP_014342424 435 QRRERHNRMERDRRRRIRICCDELNLLVPFCnaETDKATTLQWTTAFLKYIQERHGDVLK 494 coelacanth
XP_007909437 401 QRRERHNRMERDRRRRIRICCDELNYLVPFCnsETDKATTLQWTTAFLKYIQEKHGETLK 460 elephant shark

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