Conserved Protein Domain Family
bHLH_TS_NGN2_ATOH4
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cd19717: bHLH_TS_NGN2_ATOH4 
basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins
NGN-2, also termed Class A basic helix-loop-helix protein 8 (bHLHa8), or protein atonal homolog 4 (ATOH4), is a neural-specific bHLH transcription factor required for sensory neurogenesis. It activates transcription by binding to the E box (5'-CANNTG-3').
Links
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Statistics
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PSSM-Id: 381560
Aligned: 5 rows
Threshold Bit Score: 136.303
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #   # ### #    #                 ####                      
Q9H2A3       104 ETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLAD 172 human
XP_006011419  65 ETVMKIKKTRRMKANNRERNRMHNLNAALDELREVLPTFPEDAKLTKIETLRFAHNYIWALSETLRLAD 133 coelacanth
NP_001081802  73 ETVLKIKKTRRVKANNRERNRMHNLNSALDSLREVLPSLPEDAKLTKIETLRFAYNYIWALSETLRLGD 141 African clawed frog
NP_001081804  77 DTVLKIKKTRRVKANNRERNRMHHLNYALDSLREVLPSLPEDAKLTKIETLRFAHNYIWALSETLRLAD 145 African clawed frog
CAA10105      70 ETAQRIKRSRRLKANNRERNRMHNLNAALDALRDVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLAG 138 chicken

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