Conserved Protein Domain Family
STKc_Cdc7_like

?
cd06627: STKc_Cdc7_like 
Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include Schizosaccharomyces pombe Cdc7, Saccharomyces cerevisiae Cdc15, Arabidopsis thaliana mitogen-activated protein kinase kinase kinase (MAPKKK) epsilon, and related proteins. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Cdc7 is essential for cell division by playing a key role in the initiation of septum formation and cytokinesis. Budding yeast Cdc15 functions to coordinate mitotic exit with cytokinesis. Arabidopsis MAPKKK epsilon is required for pollen development in the plasma membrane. The Cdc7-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
?
PSSM-Id: 270797
Aligned: 25 rows
Threshold Bit Score: 391.588
Created: 16-Nov-2007
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                #####   #            # #                                        #        
1168817         8 SITLGDCLGKGAFGAVYRGLNiknGETVAVKKVKLskml----------ksdlSVIKMEIDLLKNLDHPNIVKYRGSYQt 77   fission yeast
XP_654672     419 VFSIANSIGRGAYGEVFQGMNadsGEFVAIKQMKVnkk------------svmKEVMEEIRLLKKLKHKHIVRYIASTEs 486  Entamoeba his...
EAL21549        8 NYQLGDLLGRGASGNVYRALNfltGETVAIKSISLlslp----------psslPDIMSEIDLLKNLNHANIVKYKGFARd 77   Cryptococcus ...
XP_001312579   39 EFQLGPKLGRGAFGCVYQGLNkdtGDYVAIKTISLtrfp-----------dalDSVQQEIDLMAPLEHPNVVKYITSHQt 107  Trichomonas v...
XP_001709184   12 RYTLHCLIGKGAFAKVWKAADevtGGFVALKQLEPkgkkka------vdqgfiKEVMSEINLLSKLNHSNIVKYRGCFLe 85   Giardia lambl...
CCJ30742       10 VYHLGDCLGKGAFGAVYRGLNlntGETVAVKQIKLhnip----------ktelKVIMMEIDLLKNLNHPNIVKYHGFFKt 79   Pneumocystis ...
GAC72363      966 TYQLGNCIGRGQFGSVYRALNlnsGQMVAVKRIKLdgrs----------ddevTELMGEVDLLKSLSHPSVVKYEGLVRg 1035 Pseudozyma an...
XP_505151      18 NYTLGDCLGKGAYASVYRALNwntGEAVAVKRIKLsdvpk---------kgdvDTIMMEIDLLKNLNHPNIVKYHGFVKt 88   Yarrowia lipo...
EGF76472        4 RYQLGECIGKGATASVYRGLNlrtGHTVAVKQLRRldlpslqaeqiavydiaiFLGQLEIDLLKQLRHPNIVALYGYEEs 83   Batrachochytr...
EIE80206      197 VYALGKSIGKGQFGEVFGGLNmdtGEYVAIKRIKRnq--------------mdCDDMNEVGVLKHLNHEHIVRYKGFSKd 262  Rhizopus oryz...
Feature 1                ####  ##  #                                   # #### #         ##  #     
1168817        78 ndsLCIILEYCeNGSLRSICKnfgkIPENLVALYTFQVLQGLLYLHnQGVIHRDIKGANILTTkdGTIKLADFGVATKIN 157  fission yeast
XP_654672     487 hgfLYIIMEYMeSGSLLNIVKkfnhLNESLSAKYIHQVLDGLAFIHdQGIVHRDIKAANILVAkdGSVKIADFGVSVQMN 566  Entamoeba his...
EAL21549       78 kenLWIILEYCeNGSLQTILKkfgkFPESLVAVYISQVLEGLIYLHeQGVIHRDIKGANILTNkdGSVKLADFGVSSRAP 157  Cryptococcus ...
XP_001312579  108 kdfLYIVMEFAeGGSLQNVQKkfenFNEHLASKYLYEVLLGLKYLHeQSIIHRDIKAANILLTk-GHCKLSDFGISVKLT 186  Trichomonas v...
XP_001709184   86 qnyLYIILELVdFGSLQTLIKqyddLGENVVACYIYQILLGLKYLHeQGIIHKDIKAANILMTssGLCKLTDFGLSQRLQ 165  Giardia lambl...
CCJ30742       80 adaLNIVLEYCeNGSLQSICKtfgkFPENLVAVYITQVLHGLLYLHdQGVIHRDIKGANILTTkeGFVKLADFGVATRTS 159  Pneumocystis ...
GAC72363     1036 pdvVSIILEYVeNGSLLHTLKafgnFPEKLVASYVVKILEGLNYLHeQNVVHCDLKAANILTTknGNVKLSDFGVSLNLK 1115 Pseudozyma an...
XP_505151      89 qdtLNIILEYCeNGSLHSICRkfgkFPENLVAVYMYQVLKGLAYLHeQGVIHRDIKGANILTTkdGNSKLADFGVATTTI 168  Yarrowia lipo...
EGF76472       84 gayLNVIMELCeSGSLQETIRkfgkIPEKLVALYMSQVLAGLGYLHgQGVIHRDIKSANILSTkdGSVKLADFGIAIRQQ 163  Batrachochytr...
EIE80206      263 kiyINIILEYVeMGSLLNNIKsfgkFPEKLAASYTYKILSGLHYLHsQQVVHCDLKAANILTTktGSLKLTDFGVSLTMK 342  Rhizopus oryz...
Feature 1                         #### #                          #        #                      
1168817       158 ALEd----------hSVVGSPYWMAPEVIELvgaTTASDIWSVGCTVIELLdgNPPYYDLdpTSALFRMvkDEHPPLPSN 227  fission yeast
XP_654672     567 GNEkqeg----gsdeDPIGTPNWMAPEVIQMqgtTVKADIWALGCTIIELItgNPPYYDLnpTAALYKIvnDDYPPFPST 642  Entamoeba his...
EAL21549      158 TAVldqsgksndgeaEVVGSPYWMAPEVIEQsgaSTASDIWSVGCVVVELLegKPPYGDLapMQALWRIvqDESMRIPEG 237  Cryptococcus ...
XP_001312579  187 DNKnp--------daLSQCSPFWAAPEVISMepiTEKCDIWSLGITAIELFagQPPYFELnaVRAMFQIvqNPEPPLPKD 258  Trichomonas v...
XP_001709184  166 DVDp----------tVVEGSPYWLAPEVINEegvSTKSDVWSLGATMIELLtkKPPFHNLtgFAAMYNIatLTEMPLPPN 235  Giardia lambl...
CCJ30742      160 SLSd----------fTVVGSPYWMAPEVIELsgvTTASDIWSVGCTVIELLegKPPYHKLdqMPALFRIvnDEHPPLPEG 229  Pneumocystis ...
GAC72363     1116 AVKkmg------nknDAIGTPNWMAPEVIELkgvTTAADIWSLGCTIIELLtgKPPYYDMlaMSAMFRIveDDCPPIPDK 1189 Pseudozyma an...
XP_505151     169 LATgsv-------enGVAGTPNWMAPEIIELngaTTASDIWSVGCTVIELLtgKPPYHNLgqMPAMFAIvnDDHPAFPEG 241  Yarrowia lipo...
EGF76472      164 LNVvd---------eTVAGSAYWMAPEVIELqgaSTTSDIWSVGCTSIELFtgHPPYHELapVSALFRIvsDDHPPIPLE 234  Batrachochytr...
EIE80206      343 MKEdea-------tgEPAGTPNWMAPEVIKLagaCTKSDIWSLGCTIVEMLtgKPPYAGMhsFAALYKIveDTEPPIPKN 415  Rhizopus oryz...
Feature 1                                           
1168817       228 i--SSAAKSFLMQCFQKdPNLRIKTRKLLKHPWV 259  fission yeast
XP_654672     643 v--SVQLKDFLFSCFKRnPNQRASSRELLKHKWF 674  Entamoeba histolytica HM-1:IMSS
EAL21549      238 a--SPIVKDFLYHCFQKdPNLRISAKKLLRHPWM 269  Cryptococcus neoformans var. neoformans B-3501A
XP_001312579  259 i--SANFKDFLTSCLTKnVTFRKNTEQLLKHPFI 290  Trichomonas vaginalis G3
XP_001709184  236 i--SPECADFLSCCFKIdPHERHSCAELLNHPWL 267  Giardia lamblia ATCC 50803
CCJ30742      230 s--SPVTRDFLMQCFQKdPNLRVSAKKLLKHPWL 261  Pneumocystis jirovecii
GAC72363     1190 c--SDALRDLLLQCFNKdPTKRPSAETLFEHEWI 1221 Pseudozyma antarctica T-34
XP_505151     242 a--SPAALDFLGQCFQKdPNLRVTAKKLLRHPWL 273  Yarrowia lipolytica CLIB122
EGF76472      235 a--SQLFINFLIECFQRdPHLRISANNLCKHTWL 266  Batrachochytrium dendrobatidis JAM81
EIE80206      416 ldlSKEARDFLSICFRKnPEDRPNAYELMKHKWV 449  Rhizopus oryzae RA 99-880

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap