Conserved Protein Domain Family
MPC
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pfam03650: MPC 
Mitochondrial pyruvate carriers
This family includes mitochondrial pyruvate carrier proteins, such as Mpc 1/2 and their homologs. They mediate the uptake of pyruvate into mitochondria. In humans, Mpc1 and Mpc2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane. MPC1 contains two predicted transmembrane regions. MPC2 contains three predicted transmembrane regions. Several studies have demonstrated MPC involvement in the control of cell fate in cancer and gluconeogenesis in models of type 2 diabetes.
Links
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Statistics
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PSSM-Id: 427425
Aligned: 41 rows
Threshold Bit Score: 147.775
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q21828        11 YFKQHSTAEWKHYflSTHFWGPVANWGLPLAALGDLKKNPDMISGPMTSALLIYSSVFMRFAWHVQPRNLLLFACHFANF 90  Caenorhabditis ...
KDE07539     248 kLEHKLNE--GPK--TVFFWAPVFKWGLVVAGLKDLSRPADKISIPQNLALTATGLIWVRYSFVITPVNYSLAAVNAFVG 323
XP_020160513   5 KLQAFWNHPAGPK--TIHFWAPTFKWGISIANVADFAKPHEKISYPQQVVIACTGIIWSRYSMVITPRNWNLFSVSVAMS 82 
XP_001527245   1 mstqSTFKKAFKYmcTTHFWGPVSNFGIPVAAIMDLKKDPDLISGPMTGSLILYSLVFMRYSMAVTPKNYLLFGCHLVNE 80 
XP_004177513  13 liSKYINKQTLKYvfTTHFWGPISNFGIPIAAVYDLQKDPNRISGPMTGALIAYSAVFMKYALAVQPKNFLLFACHFINE 92 
P53157        13 FLQKYINKETLKYifTTHFWGPVSNFGIPIAAIYDLKKDPTLISGPMTFALVTYSGVFMKYALSVSPKNYLLFGCHLINE 92  Saccharomyces c...
Q6FS56        13 iIQKYINKETLKYvfTTHFWGPVSNFGIPIAALYDLKKDPTLISGPMTLALVAYSGVFMKYALAVTPKNYLLFACHFINE 92  [Candida] glabrata
CCC69953      13 lIQKYINKETLKYvfTTHFWGPVSNFGIPIAALYDLKKDQTLISGPMTFALVAYSAVFMRYATAVTPKNYLLFGCHFVNE 92 
XP_003956348  13 vLQKYINKETLKYvfTTHFWGPVSNFGIPIAALYDLKKDPTLISGPMTFALIAYSGVFMKYALAVTPKNFLLFGCHFVNE 92 
CCE93514      13 vIQKYINKETLKYvfTTHFWGPVSNFGIPIAAIYDLKKDPTVISGPMTGALVIYSAVFMKYALAVTPTNYLLFGCHLVNE 92 

Q21828        91 SAQGAQLGRFVNHNYLHYVEDPVhhKLMMKKEVL 124 Caenorhabditis elegans
KDE07539     324 ATGIASLSRAFAWKYMTPEEQMKvrAERAAQEAK 357
XP_020160513  83 GTGLYQLSRKMRKDYFSGAEKEAaaASLELev-- 114
XP_001527245  81 IAQLGQGYRWVSYHYLDEGK-----AKDKAEREA 109
XP_004177513  93 TAQLGQGFRFLNYHYFIDDA-----KRAKIDEKF 121
P53157        93 TAQLAQGYRFLKYTYFTTDE-----EKKALDKEW 121 Saccharomyces cerevisiae S288C
Q6FS56        93 SAQLGQGYRFIDFNYFKSDE-----EKNKIIEEY 121 [Candida] glabrata
CCC69953      93 VAQLAQGYRFIDFNYIMSED-----QRQEIHRKH 121
XP_003956348  93 AAQLSQAYRFIDFS-LKSDE-----QKAAIQSKY 120
CCE93514      93 AAQLGQGYRFLHYNYLADED-----EKKAIDEKW 121
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