4J2U


Conserved Protein Domain Family
ECH_2

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pfam16113: ECH_2 
Enoyl-CoA hydratase/isomerase
This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.
Statistics
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PSSM-Id: 465024
Aligned: 251 rows
Threshold Bit Score: 252.776
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4J2U_B         34 AGRITLSRPAALNALTCAXVQEIDAALRGWIGDPEVELVVI-DAEGPRAFCAGGDIAELHGRGVAGDHAfgqdFWRVEYR 112  Cereibacter s...
EFC39337      936 TRCLQINRPRESNRITSEVARDLLHQFKVMDTNPIINLITL-SGIGNGFLSAGYDFRELQNLMDKGDYEtvysLVRDTHK 1014
EFA76756      192 YARAFLNNRKTLNAIDISTIDLLEEFVKDKIKDDTITSFSIhTSTPGVIHSAGTDFVTLFEKRNTELPEq---YFRKLYK 268 
EGC32625      166 YKRAMLNNREKLNVLDLSTLTSIEHFIKTQVANDIVGSYSIhTTTPGAIQSSGIDFVNLYESNQNRKYIs--dYFKKISK 243 
EGG13538      178 FSRALLNDRKTLNSLSDTTLRLIDEYLKEVIINERISCFSLhTSTPGLIQSAGTDFVAMFEKRNTEYPQe---YLKKLYK 254 
Q8I523        190 ICEIILNRPEKLNAINKDMINALLNIIKSLDNDERCFMVII-RSTNSNCFSSGSDVKYVVENKEQgi-----qHLKQLYL 263  Plasmodium fa...
XP_004351918   53 CLKIILNREKALNSLTLEMINHLLNLLKKYENDKRVTFVLV-VGAGDRAYCSGGDLLEFSSSVEM-Sh----rLSNTEYK 126 
Q55GN0         49 CKRIILNRSEALNSLTMEMLKFLSEKLKEFNNDDNCKFVII-NSSTEKSFCSGGDIKEFSQLSRSSAGVn--eFIRVEYA 125  Dictyostelium...
EFC47358       73 CLCITLNRPKSFNALSLSMIRSLRRILEQALSDTKVHFVIL-QSASDKAFCAGGDIKDLRRGFEYaq-----qFFTEEFS 146 
XP_002515579   58 VAVITLDRPKALNAMNLDMDVKYKSFLDEWESDPRVKCVLV-EGSSPRAFCAGGDVKAITSKNQLSHMIe---VFTAEYS 133 
4J2U_B        113 XNDRIAAFPK--PIVSLXQGFTXGGGVGLGCHARHRIVGETS-QISXPECAIGLVPDVGGTHLLAR-A-PG-RIGVWLGL 186  Cereibacter s...
EFC39337     1015 LAYYAANCET--PTMSVINGLMLGPGTSLGTSANYVIATPGS-LFSAADSAYGYFPDCGVTMLLSRvNqKHeGLGTFLGL 1091
EFA76756      269 FFYLLAASPK--PHVSILDGLAVGSGAAFTANSAVRVATENS-IFSVPDCAIGFFPDAGMARFLGK-L-PG-SLGRYLAM 342 
EGC32625      244 VFYLMSVAPK--PQLSIIDGLTVGAGLGFTANSGFRVGSENS-IVTISDCALGFFPNAGNVRLLNR-L-PD-GIGLYLAL 317 
EGG13538      255 AMYLLAITPK--PQINILDGLAVGSGAALTANSGIRVVTENA-VMSFPEAALGYFPDCGSMRLLAR-M-DG-FLGKYLAL 328 
Q8I523        264 YINYISQMKK--NLLCIWNGYVMGGGLGISIYSKYKVINKNA-IFAMPENKIGFFPDIGCCYFFRK-Y-FGrNIGLHLGL 338  Plasmodium fa...
XP_004351918  127 LDYLIHTYSK--PYVSIVNGIVMGGGVGISIHGSHCIVTERA-LWAMPECFIGYFPDVGTNYQMSR---LG-AIGLYLDL 199 
Q55GN0        126 MDHLIHTFNK--PILSFVNGIVMGGGVGLSIHSSHRIIGDNV-QWAMPENRIGYFPDVGTSYFLSR---LG-SIGLYLAM 198  Dictyostelium...
EFC47358      147 LNYYIHEFCKvkPIVSMLNGITMGGGVGISIYTNLRVANRKRfQFAMPEVFIGIYPDIGASFFLTR-AcSSiGIARYIGL 225 
XP_002515579  134 LICKISDYKK--PYISFMDGITMGFGLGLSGHGRYRVVTERT-VLAMPENGIGLFPDVGFSYIAAHsPgEG-SVGAYLGL 209 
4J2U_B        187 TGARXGP-GDAIFAGFADRFVPEADW--PDLI----AALEGG----------DLALPDHA-------APe----GRLpvl 238  Cereibacter s...
EFC39337     1092 TGAQVKS-SDLVNCGIATSFGMESMS--QYIA----ERLLEVqtg----anqDDIHNCIVest-esdVPalsfaFELy-- 1157
EFA76756      343 TGGRLRG-SDIMESGIGNFYIRTNQI--QYIE----EWLGRVpin-----rsDRLFANLDiht-enwDNkq-siQKThye 408 
EGC32625      318 TGRRIRG-TELHEAGITDFFVLTEDI--QGFD----RNLSHCfpk-----nhNRLFESIVlst-tepRSyl-ngKKThlt 383 
EGG13538      329 TGRRLRA-GELIQTGVGNFYMRTAHI--PLIE----DSLCQLppn-----rpDRMFLHLDths-dsfDDlv--sQPThyt 393 
Q8I523        339 TSLRLNE-VDLINFNVCNNYIENVDTfmDNL-----NNIKATnqe-----dfNKKLNNLLtnkyvskMSynksnNPVltd 407  Plasmodium fa...
XP_004351918  200 TGTRIKY-RDLVGLGIASHHVPSDML--DRLV----RDLTENtvdt--trqlDFIINLYRkqv-gyrLHniepsTMVewl 269 
Q55GN0        199 VGVKINS-KDLINVKLATHYIPNELF--ERTL----EELCNDddieg-yrqiEFILNKYRktl-ypdKEsshlv------ 263  Dictyostelium...
EFC47358      226 TGAKLGA-TDSLFSKLVTNVIDNEEVf-YELRrdlfEKFIPTene----snlEKQLEKFIqiy-ekkGNtv-lnSTLgqv 297 
XP_002515579  210 TGKRISTpSDALFVGLGTHFVPSGNL--GSVK----EALFSMtfsqdpnddiKALLAKYSnep--------eseAELkll 275 
4J2U_B        239 ---qdEIDRLF-AG--T-LAEIPARLE-------------A--TDTP----LAAEAL-KALR-RSSPLALAATLEILQRL 290  Cereibacter s...
EFC39337     1158 -----KIKEHF-SNkkS-VEEIIQSLKntitdstktkperD----------WAANIL-ENMN-QLSPLSLKVTFRAIQEC 1218
EFA76756      409 q-ykeAIDRCF--SkaS-VEEIMDALRaet--------qhPa---------WAKRCL-DNMN-RMSPLSLKLTLVFMDYA 465 
EGC32625      384 t-hqdAIKRCF-DNktT-IEEVLQALEnet--------efAe---------WAERCI-RNIR-RSSPISIKLTMRLFNET 441 
EGG13538      394 t-yreAIDRCF--SkdT-VEEIIEALHker--------qhSd---------WAKRCI-QNMN-KSSPLGLKLTNALYRHV 450 
Q8I523        408 e-linNINTYY-SSanT-LEDLITKLKk---------------DNND----FCKKLL-SDIY-SNCYFSCMFWFSYYLYN 463  Plasmodium fa...
XP_004351918  270 v-qnqCLERCF-GNhiKsVQEVLDNLEne----------iKnnNGDEkvrkWAEQTL-TKIT-GSRPLSICACFKAFRDS 335 
Q55GN0        264 -lyqsIINRCFnNKefKsVKEILNQLKveien----vdnkNnkDEIE----WASKTLsILLD-QLCPTSVCVSFEIIKRA 333  Dictyostelium...
EFC47358      298 drfrrVIDYCF-GEaqS-VKEIISNLKwyke-----hhpcRsqSDNE----FIDSIL-ELFSkRASPTSLVVTFEALERG 365 
XP_002515579  276 ---lpQIISTFsAS--NsVKEITEELKkhq--------qsAdtKVAE----WASDAL-QGLG-KGAPFSLCLTQKYFSKV 336 
4J2U_B        291 GPSAg--------IREALDLEYRFTYRAQG-QADFLEGIRAAIIDKDRSPrWRHGDPEAVRP-EEVASLL 350  Cereibacter sphaeroides...
EFC39337     1219 DQGLg--------LDETYQRDYRIASRLIK-SKDFKQGVNSVLTGIE--PvWEFESVEKVPD-SVVDSLF 1276
EFA76756      466 LQPNplld-qplsLKEHFEMEYRITSSLLEeGSDFWEGIRANLVYK-RAPqWKYKTLADVTD-EVIEHHL 532 
EGC32625      442 PTDGk--------GKDYYERDYNISMALTRdHSDLWEGIQSLLIQN-REPmWSYKRVEDVPD-SLIDEII 501 
EGG13538      451 AEAKet-----isLRDLLSLEYKIANCLFEeGSDLWEGVRSNLVYG-RAPnYRYKTLSDVTD-SVIEDHF 513 
Q8I523        464 YEKS---------LEEVLNNDFKITQYFLFhKNSFERGVTEVLVKKNKNFqWSKDEETNNADfEDIDDIL 524  Plasmodium falciparum 3D7
XP_004351918  336 LNLS---------IDDVLKMDNRVGTHLTQiEEDGREGIKAALFDKTYKPqWIPPTIQQVDP-NIVDSLF 395 
Q55GN0        334 LQMN---------IDQIFQMEVRVGTRLGN-RQDLTQGVFKTLIDKTHKPiYSPSSIYDINQ-SFIDSFF 392  Dictyostelium discoideu...
EFC47358      366 RKASs--------LKQVLDLDKLLCTKLVG-QHDFVEGVRAVLVDKDQKPkFKPATLDELNVhQVIKEIF 426 
XP_002515579  337 ASAYgkpnselstLNGVMKTEYRIALRSSL-RNDFAEGVRAVLVDKDQKPkWNPPSLEDIDQ-NEVESLF 404 
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