Conserved Protein Domain Family
Autophagy_act_C

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pfam03987: Autophagy_act_C 
Autophagocytosis associated protein, active-site domain
Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the vacuole. The cysteine residue within the HPC motif is the putative active-site residue for recognition of the Apg5 subunit of the autophagosome complex.
Statistics
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PSSM-Id: 461120
Aligned: 159 rows
Threshold Bit Score: 56.9552
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001729753           62 YLPKNKQFLMIRNVpclrrvsavhprkfagrpwfprasstkslsrldNEARDLHGvs--dNTEQsiyleesgdkahgand 139
OWR41827               10 EFVYAARDFVDLSDkyrdsw---------------------tlhqndNEILQTYIrk--eEFIShrden----------- 55 
EDX06082                8 DFLGQAKQFLEMSQklgdnwml------------------eqkdsnePNTYLKYSq----KIKCqggkd----------- 54 
XP_003240399            7 QFVEYATDLKNHSDsidg-----------------------------gwnlRQHQc----PMILlwkt------------ 41 
GAA96361                6 AFNEACRAWLTTEGrstswqw--------------------ltpsslPD--YGYLqr--aQLHCaardvsataeddligq 61 
WGS:AAWC:PGTG_03026.3   6 EFNQGSQRFINNSTdtpnrcnrgwkw----------kqyqnrtsriiIEQDLGCLy----HEPVdrrlfintqdsekcke 71 
XP_007405161            9 EFEESCNEFLTFWNspqnqndqsdfns-------hhflkgwkrethpMNDRFGYLvs--eALDRilnkksfsrnqdyess 79 
EFJ01763                6 DFDTACQSYVSARPtdrgicgw-----------------qwnaysspYQTSVGYLartttEFALhdpsepfataemeais 68 
XP_002911185            6 QFEAACKSLATKWSsespldprth-------------aytdwvwhnpYP--YGYLa---rTKRYartaspgafeeelgqe 67 
XP_002063545            8 EFLTQSRQFLRMSQhlndkwelyeknqeep-------------------------------------------------- 37  Drosop...
XP_001729753          140 dedwilthvdgasgtpsaenspmttsptsklhvatsgsafsaqesvptsttssmvlgcvadeesedssqlrtpdeldglg 219
OWR41827                  --------------------------------------------------------------------------------    
EDX06082                  --------------------------------------------------------------------------------    
XP_003240399              --------------------------------------------------------------------------------    
GAA96361               62 ed------------------------------------------------------------------------------ 63 
WGS:AAWC:PGTG_03026.3  72 eeegi--------------------------------------------------------------------------- 76 
XP_007405161           80 neqnqdeisslssqlises------------------------------------------------------------- 98 
EFJ01763               69 vgdapvte------------------------------------------------------------------------ 76 
XP_002911185           68 lgqefg-------------------------------------------------------------------------- 73 
XP_002063545              --------------------------------------------------------------------------------     Drosop...
XP_001729753          220 gfaegvkeredpaqyvarptaslsdhlassrkqmalRTYDCMITYDKYYQTPRMWLLGYDEHGIPLRPSDVYED------ 293
OWR41827               56 -------------------------------dkvflYRAEYVIFFNLSYGVPSFSFNVWDCSGKLLTLEEV-RQ------ 97 
EDX06082               55 -------------------------------nsaelVSVEYHVVFSVSYQVPMLFFQAHRSDGSLLDLEAIWRL------ 97 
XP_003240399           42 ---------------------------------kfpIVCEYHILYNPSYSCPDVFFNMWYTDGKLLSLEHVWSL------ 82 
GAA96361               64 ------------------tvqevadpssangteyqsLRLDCSICYSATFQVPVLYFRGFSQGGAPLQLKDILQSs----- 120
WGS:AAWC:PGTG_03026.3  77 ---------------vheqedeaatiripdcrpyvpIKYQASVVFSDTYRVPQLLFQAYKPDGTQLNLDELIHTdify-- 139
XP_007405161           99 --fdeelqdieipveledesilstssglkttdepmiIKFQTWIVYSETYRVPHFLFNAYKSDGTSLTLEELMRSnifnpq 176
EFJ01763               77 -------------swdevvaeledeaaaprsttkepLNCQQYVVYTPGFQVPAFYFSLHDARGSPLRVDDLIRT------ 137
XP_002911185           74 ---------------qeevvcqddvatgstpgdvesVLSQQFVVFSATFQVPAFYFTVHDTTGAPLSLDKLLAS------ 132
XP_002063545           38 --------------------niflkfsqkvrskedlINVEYHIVYSVSYQVPMLYFQAHRSDGSLLDLEATWRL------ 91  Drosop...
XP_001729753          294 --------------VASD----------------------------H-AFKTVTTEPFPH-GTPgvgaldtvamgtaskr 329
OWR41827               98 --------------ISLIktt-----------------------keN-FYSVVSQQEHPVlYKP---------------- 123
EDX06082               98 --------------FMPEsk------------------------asD-LHQILTQMDHPVlFRP---------------- 122
XP_003240399           83 --------------VHSFlkqn---------------------vvhD-KWNAITQEMHPFfNSP---------------- 110
GAA96361              121 -------------fIKPD----------------------------ApSTLSISQGEHPVaGTA---------------- 143
WGS:AAWC:PGTG_03026.3 140 -----------gdsLEYPmnliksstssskedkdkeeeeeeeegkrV-QLPILTRTIHPIdNQT---------------- 191
XP_007405161          177 tshlsfvddhhteeLSNPnlvdleypfntl----ersakpkdedqnV-ILPFMTQVEHPFtQIP---------------- 235
EFJ01763              138 --------------SLFRpsafdattr----------nsfaitpsaS-AFPLLSQGDHPVlGTP---------------- 176
XP_002911185          133 --------------PLFKfelpegaas----------tgfaltlpnA-PFPLLSQGEHPSlGTP---------------- 171
XP_002063545           92 --------------LMLEfqsr-----------------------reeLLQMLTQQEHPVlFRP---------------- 118 Drosop...
XP_001729753          330 kslaVhvASIHPCKHANMMRRMLQvfheaensskgksatcgtsssehpssssttsslltlmmqrargmrptnLANNQVSV 409
OWR41827              124 ----Y--FIVHPCRTAVILQEFKS------------------------------------------------------KS 143
EDX06082              123 ----F--MALHPCRTAEVLKQFGK------------------------------------------------------PS 142
XP_003240399          111 ----F--FRLHPCKNTHVLEMLGF-------------------------------------------------SSKNIYE 135
GAA96361              144 ----C--HFLHPCNTAELIREIKL--------------------------------------------------ASADTS 167
WGS:AAWC:PGTG_03026.3 192 ----Y--WGLHPCNTQTILKEILEee--------------------------------------------hrNHPKKLPP 221
XP_007405161          236 ----V--WSLHPCNTAAVLEEMLT------------------------------------------------GCMDKLNS 261
EFJ01763              177 ----C--WYIHPCETATALSEIMSemq------------------------------------------yddGGSRERRL 208
XP_002911185          172 ----C--WYLHPCETERAVEELVReae-------------------------------------------qpDWTPEHRL 202
XP_002063545          119 ----F--MALHPCRTAEVLDQFGQ------------------------------------------------------KS 138 Drosop...
XP_001729753          410 DMYLVLFLQFMASIMPTMELDT 431
OWR41827              144 RNIILTFLGLIIPLVQLNLPLE 165
EDX06082              143 SNQVLTFISLYGPHVQLYLPNA 164
XP_003240399          136 FNPLIAWLSTISPIIGLEIDLS 157
GAA96361              168 DAVLPTWLMILDQVDSTCDGQG 189
WGS:AAWC:PGTG_03026.3 222 QLVIESFFALVSSKIRPPQHCL 243
XP_007405161          262 RVTIEAFLTLVNGLINLRRSSN 283
EFJ01763              209 KRTLEAWFMLLSSIVNLQHRTE 230
XP_002911185          203 ERWLELWLMAVGAVLNLGAPCV 224
XP_002063545          139 ENLVLTFISLYGPHVQLQLSNG 160 Drosophila willistoni
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