6TD6


Conserved Protein Domain Family
HH_signal

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pfam01085: HH_signal 
Hedgehog amino-terminal signalling domain
For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.
Statistics
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PSSM-Id: 460055
Aligned: 13 rows
Threshold Bit Score: 253.836
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6TD6_B         88 GRG--LGRHRARN-LYPLVLKQTIPNLSEYTNSASGPLEGVIRRDSPKFK-DLVPNYNRDILFRDEEGTGADRLM-SKRC 162  fruit fly
EKC39089       30 PRGs-GRRHRTGN-RTPLVYKQHVPNVSENTLGASGLAEGRISKEDPRFK-KLVTNDNPDIIFRDEEGDGTDRIM-TQRC 105 
XP_005655607   26 GRGpvGRRRYVRKqLVPLLYKQFVPSVPERTLGASGPAEGRVTRGSERFR-DLVPNYNPDIIFKDEENSGADRLM-TERC 103 
XP_001943707   41 LRGp-SKFRNPRK-MKPLVFQQHEPNVSEYSITASGPPEGRIQRNDSRFM-ELVPNYNADIEFKDDEGTGADRLM-TQRC 116 
XP_015199891   29 GPGh-GRRPKMRK-LTPIPYKHSVPNFSENNLGASGRAEGKITRSSERFK-DLVANYNPDIIFKDEENTSADRLM-TKRC 104 
XP_005801480   30 GPGy-GTRSRPRK-LTPMRYKQFFPNFSENTLGASGRAEGKISRNSERFN-QLVCNYNPDIVFKDEENTSADRVM-TKRC 105 
EGW06030       27 GRGf-GKRRHPKK-LTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFK-ELTPNYNPDIIFKDEENTGADRLM-TQRC 102 
ESN91655      213 GRSyfSPRKGPRK-MTPFVLKQHVPNLSETTLGASGQPEGKVSRGDPEFK-KLVTNKNPNIIFQNSEGTGADRVM-SKRC 289 
XP_025016100   27 GRSg-GRRRIPRK-TTPLVLEQHIPNVSENTLSASGPSEGKINETDSRFT-KLVPNYNPDIVFKDEEGTGIDRIM-TTRL 102 
2_pfamImport    4 GPRh-GTRPSERI-LRPLLRQQYVPHLSEGTVGASGPSEGRIYRNTPKYR-KLERNYNPDILFREDEEDGSARIM-TKRC 79  
ABX89898        4 GKA---AFDRDNR-AIPMKIREHIPDTSETSLQASGPSR-KIKRGSNGYK-ELITNADPNIVFR-EDKAGNNRRM-SKRC 75  
NP_001027634  133 GHGsgGSRMPGRE-LVPFLKGEYVPKMSEQTIGASGPVTGRIRADTPRFRqELVPNWNTDIEFRDEEESNEDRFM-TPIC 210 
1_pfamImport    4 GQGngAPRKPGRE-LVPFLKGEYVPKMSEQTIGASGPSTGRITRTSPRFHhELVPNWNTDIEFRDEEESNEDRFYdAGTC 82  
6TD6_B        163 KEKLNVLAYSVMNEWPG-IRLLVTESWDEDY----HHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVS 237  fruit fly
EKC39089      106 KDKLKILAISVMNTWQG-VKLRVTEAWDDDG----HHAKDSLHYEGRAVDITTSDKDRAKYGMLAKLAVEAGFDWVYFES 180 
XP_005655607  104 KERVNALAIAVMNMWPG-VRLRVTEGWDEDG----HHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYES 178 
XP_001943707  117 KEKLNTLAISVMNLWPN-VRLRVIDGWVD-------RAGSSLHNEGRAVDITTSDRDKSKYGMLARLAVEAGFDWVNY-N 187 
XP_015199891  105 KDCVNALAIAVMNQWPG-VRLRVTEGWDEDG----HHPPNSLHYEGRAVDITTSDRDPRKYGTLAQLAVEAGFDWVYYES 179 
XP_005801480  106 KDCLNRLAIAVMNQWPG-VHLRVTEAWDEDG----HHPQGSLHYEGRAVDITTDDRETKKYGILAQLAVEAGFDWVHYES 180 
EGW06030      103 KDKLNALAISVMNQWPG-VKLRVTEGWDEDG----HHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYES 177 
ESN91655      290 SDKLNNLASLTMEQWPG-VRLRVVEAWDEDE----THPEDSLHYEGRAVDVTTSDKDKSKYGMLARLAVEAGFDWVHYEY 364 
XP_025016100  103 KEKLDILASLVQNHWPG-IKLRVIEAWDDGS----QFNPDSLHYEGRAADITTSDKDNSKYGVLARLAVIAGFDWVLYES 177 
2_pfamImport   80 KDKVDLLSTLVRNRWAG-VSLQVISAWDGDG----LHPRGSLHYEGRAVDIKTSDDDTTKYGLLARLAVEAGFDWVFYES 154 
ABX89898       76 ERKLKILSSLVRKEWIGdVKVRVIRAYDDGTskkrHHGPHSLHFSGRALDITTSDEKRDKLPMLGRLAYRAGFDWV-YRA 154 
NP_001027634  211 RARLDYLAILVANQWAR-VKLKVLEAWDDGN----DKANDPLHYEGRAVDITTDDADRNKYPILARLAVVAGFDWVKYDG 285 
1_pfamImport   83 KERLDNLAIRVANQWVR-VKLKVLEAWDEGN----DRLDDPLHYEGRAVDITTNDQDRRKYPMLARLAVEAGFDWVYYND 157 
6TD6_B        238 RRHIYCS 244  fruit fly
EKC39089      181 RGHIHCS 187 
XP_005655607  179 RNHVHVS 185 
XP_001943707  188 RRYIHCS 194 
XP_015199891  180 KSHVHCS 186 
XP_005801480  181 RYHIHCS 187 
EGW06030      178 KAHIHCS 184 
ESN91655      365 RSHIHCS 371 
XP_025016100  178 RYHVHVS 184 
2_pfamImport  155 KFHVHAS 161 
ABX89898      155 KAYIHAS 161 
NP_001027634  286 KV-VHCS 291 
1_pfamImport  158 NI-VHCS 163 
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