6EZN


Conserved Protein Domain Family
DAD
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pfam02109: DAD 
DAD family
Members of this family are thought to be integral membrane proteins. Some members of this family have been shown to cause apoptosis if mutated, these proteins are known as DAD for defender against death. The family also includes the epsilon subunit of the oligosaccharyltransferase that is involved in N-linked glycosylation.
Links
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Statistics
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PSSM-Id: 460448
Aligned: 105 rows
Threshold Bit Score: 83.3255
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6EZN_B                         24 QETFKTSKRAYFAQIekYPKLKLIDTFCFFLVLLGVIQCTFIILIrDNFPFNAFLAGFIICVGQFVLLMSLRLQLC--N- 100 Saccharomyces cerevisiae S288C...
A0EFY2                         13 LGIAASFWQQYSTKT--PQKLKIMDAFSLYCFILVIIQLFYCALV-GDFPRNSFLSGIFAAAGAMIINICLRKQLNpeTk 89  Paramecium tetraurelia...
XP_002808792                    2 NKILSTFYENYRN-T--PRNIKFVDIYILITLVNILLLYMYGYFS-CSFDEKISVAAIFTALGNLTFSIALREQIS--Nk 75 
WGS:AAGF:cds.TTHERM_00411530A  37 RDIFRTFWNSYKKNT--PSKIKLMDAFVVYCIMIICIQFFYYFVV-GNFPQNSLIIGIFAPLGSATFTVCLRQQIS--Qk 111
XP_001327154                    7 SGILAELKEVYGKQ---KSHFRGLDIFALFGIMVALIQLVYSGLT-HGYPFCSMVSAVCMSLGFTVLVISLRLHLTpeIe 82 
WGS:AAFB:cds.EHI_103780A       18 ESFIKVLLTSYSKET--PSRLKMIDCFLIYQLITAALVLVYGFFF-CHNPLNAFLAALFSCAGMFVFTMSLRLHES---- 90 
ESS29091                       75 TCIVRDLARAYLQRY--PPRILMMDAFCACLLLMAGLLVLYAVLTrSTFPFNAFLSAFISCVGTAVLTVCFRIQIT--Nk 150
EEA04882                       24 TEVFTEIMTSYLKVV--PKHIQIIDCFISYLAIITITQLIYCILIgMAYPLNSFIAGIFTSGGTALLVSALRIQLIap-- 99 
Q5CRL9                         47 LDVFQEMKQAYFSKV--PENIQILDSFILFMALISIIQIIYCLLIrTTYPIDSLIGGVFCTTGTALLVSALRIQLTcp-- 122 Cryptosporidium parvum...
EMR11368                       25 LESFYEFFNNYQNNT--DKSLKKIDYLIIFLVFSACIQLLYCILS-GSYPFNSFLSGFISTVGQFVLTVSLRGQFNikDe 101

6EZN_B                        101 -SFPGISKNRAFAEFIVASLILHFVCLHFIN 130 Saccharomyces cerevisiae S288C
A0EFY2                         90 --YMEISNERAFWEYLAAMVVLFLTVINFLG 118 Paramecium tetraurelia
XP_002808792                   76 -sLFNIKREKIIFDFVLCSLVLYIGVFSYMh 105
WGS:AAGF:cds.TTHERM_00411530A 112 tRYMNQSSDRSFWEYFLSMYIMFLACINYLG 142
XP_001327154                   83 sS---ISNYRAFAEYIVALSLLFLFGWNFMN 110
WGS:AAFB:cds.EHI_103780A       91 ---EEGSSKKYFVEYVFCVILLQLSVANFLG 118
ESS29091                      151 sIFK-LTEERALADFLLCSLLLQVAVFTFIG 180
EEA04882                      100 elFDNISPKTAIFDFLICSFVF------FIG 124
Q5CRL9                        123 syFGDVSPKTAFTDFVICCIVF------FIG 147 Cryptosporidium parvum
EMR11368                      102 eNNENISPERAFGDFVFSSLILHFFVITFLG 132
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