3TX3


Conserved Protein Domain Family
EI24

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pfam07264: EI24 
Etoposide-induced protein 2.4 (EI24)
This family contains a number of eukaryotic etoposide-induced 2.4 (EI24) proteins approximately 350 residues long as well as bacterial CysZ proteins (formerly known as DUF540). In cells treated with the cytotoxic drug etoposide, EI24 is induced by p53. It has been suggested to play an important role in negative cell growth control.
Statistics
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PSSM-Id: 462129
Aligned: 262 rows
Threshold Bit Score: 32.1514
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3TX3_B        16 YIGRGLELIRT-KGL----------RRYV---VVPI-LTNLIlfslaftwlygevdywlnrf--------------mswl 66  Idiomarina loih...
EEH55934      73 CALDGAKVAIAsPSE----------AWKP---LTAA-TLTAAlaldgagfyaasawlap--------------------- 117
WP_012825447  11 GLRAALGNRAVyAVY----------FRFT---LTLL-VLSLVllgglgalvwwltepasaqgaaasaqgaaaadqgglla 76  Haliangium ochr...
EDN05201      15 ltlvGAHRALQnPSLfksqhyrqaaLAVCagiAIRL-IISIPvvgvkfviwllswvvnldaat-------------wddt 80 
CCK72673      53 fPLQGFYEVVTkSKY----------WEMT---GLLL-VCHLVlfvv---------------------------------- 84 
XP_003320249  60 RISRIVSQLQSnRAL----------RSLI---VQNS-ALQLLcias---------------------------------- 91 
EGN95465      60 RWDIVVTTVRSdPEI----------RSNV---LKSL-LLNTVslts---------------------------------- 91 
EST09690      94 rwpeaFKLIASsSEI----------RNGV---LKGL-LLSGTiaav---------------------------------- 125
GAA90013      15 YPLRGIYYFAShRYL----------WPLFktrLIPIvLLSAFiyvllflfayl--------------------------- 57 
EPB84401       7 ypvagIVYFAThPQL----------WIKA---LCPF-LLTLIfgil---------------------------------- 38 
3TX3_B        67 pdffqwlefilwplavITIIALF----------------------------SFIFS------TIMHLIAAPF-------- 104 Idiomarina loih...
EEH55934     118 gddagavralaskvllVAVDGAW----------------------------VFVAP------LIAIAIVQQV-------- 155
WP_012825447  77 eygldalvggglwvlrVLGLLIA----------------------------ALASP------LIAFLLIGIV-------- 114 Haliangium ochr...
EDN05201      81 iishldfistyvlqvpFLLMTLM----------------------------RYLTP------TLDDMFMESL-------- 118
CCK72673      85 -------------iaaIIYIPLM----------------------------TLLSPlmvllgPIGVILVHIQ-------- 115
XP_003320249  92 -------------lvaLEAYADShrsssnirs-----------tldilfniFWLFPi----gMISIAMNGTItesclhsk 143
EGN95465      92 -------------iymFDLLLHPllrdhpswlh---------rnvgwfyqiLWLLPv----vGASLYLNGSW-------- 137
EST09690     126 -------------vffFELAFFPkilfqgppvknvqnmaesgsivgglgnvFWLYPl----iGGSYLLASSW-------- 180
GAA90013      58 -----pqvaflsifqgVGAWING----------------------------AFLVLgeg-aaIVAALFEAFFv------- 96 
EPB84401      39 -------------slvLSFVYLLplqahali------------vakcpvwlAWTVS------VIFVLLESAV-------- 79 
3TX3_B       105 --NGLLAEKV------------------ER-YE------SGESlgd-------egfLGLFKDIPrt-------------l 137 Idiomarina loih...
EEH55934     156 --LPLLGEKIlfdalratagmpsatvsdEDdDVdddgdaSSSSssss-----ssssAFVVHPGRrarveqleaspglgir 228
WP_012825447 115 --FPVFAETL------------------FFaGLrvmapkRAHelea-------apgLAFLPSLW---------------- 151 Haliangium ochr...
EDN05201     119 --RWVDSTYI------------------EK-HKsdhpegLRALyyphlrmysvrrdGATTSTLAsslttf-----viryg 172
CCK72673     116 --WIIQSQAIsgfvvkltiwptyqyrifQMaLLyntgtcSKPMkrpgiqrstqpaaYRGVNTDW---------------- 177
XP_003320249 144 hrTQEVSRIVlpaftiaswleivdylktKLr------------------------------------------------- 174
EGN95465     138 --CNLIAKRTlvlqhgtra-aqqqpvsyN----------------------------GLLNTLA---------------- 170
EST09690     181 --TSDIAQAAyklrhghvrrltlsnpslPP---------------------------GTSRRLV---------------- 215
GAA90013      97 --DETLVDIF------------------DSvLVs-----EGHGelvtmsrvlypqgDDVVKRLGkptks-------avya 144
EPB84401      80 --FDLIFFAVlmafmqdalfdatlkargLErMfsnrvpv-----------------------------------sgmrlc 122
3TX3_B       138 kREMQKLMYYIPRAL--GFFLL----SLv-iPvIgQ----VLWYI-----FVCWmMSIQYLDYPFDNhklSFPRMRSELH 201 Idiomarina loih...
EEH55934     229 gLGVAASRAQSLASL--TALVAplgvGVsfvPvGgPivatALTAA-----VAAYaLAWELLDPYFDKaqvGFEQQERVVW 301
WP_012825447 152 -KSLRLLLHLLGYTV--IALLLg---II---PvVgVvlgpVVQFW-----GTGKvLGWELLDPYFSKrsmRYPAQREYVG 217 Haliangium ochr...
EDN05201     173 rRTATSLAVYLLSLL----------------PvVgIfvipAASFYafnkaLEPYfSRIKY----------TKEQKRLWFR 226
CCK72673     178 -SKRISVSMHILYVVgrFLFFL----LIsliPiVgPivvnLLHSS-----SRAAaYIRNYLEWRG-----CEPAQMKELK 242
XP_003320249 175 -SDYPRILILLNYLL--MAKGLlw------vPfVgFplsfTFSSI-----GNSF-YCFEPYWLKDGL---KFEERLNLLE 236
EGN95465     171 -TSAYRAVMVFTSVV--VSFAIgs------vPyLgQfasfAFMCW-----VDAY-YCFEFIWVARGL---SLSRRVRHLE 232
EST09690     216 -QEIYRIILILNYTI--LYVLLgr------iPyLgRplsfLFMCL-----VDGY-YCFEQAWISRGW---SLDRRMRYCE 277
GAA90013     145 pFSLRQIVEFI------VLLPLn---FI---PvAgTpmflVLTGY-----RAGPfHHWRYfql----ldlSKQQRKERIR 203
EPB84401     123 cRGISSGLALLWILVlaQVLVLiitaPLhliPvVgTfiacYINGW-----VACWgHHLHYDIEFRGF---SVSDSRSFAW 194
3TX3_B       202 -QQRSKTLGFG---------FGVTVLTMIPLINLII 227 Idiomarina loihiensis
EEH55934     302 -DNRAALICFA---------APFAAGLAIPVVGPFg 327
WP_012825447 218 -ARGFAFVGFG---------LPWMLVLAIPVIGPLl 243 Haliangium ochraceum
EDN05201     227 -DRAGVLFGFA---------IGFYTMLTVPLLGVLV 252
CCK72673     243 kVRSGLFWAFG---------IPATLLDLVPFISIVS 269
XP_003320249 237 -QQWDYHLGFGlimttltsiWPHHNILNLSLFTLLF 271
EGN95465     233 -ERWAFYFAFGlpsa--aicTWGSGLANAALFALMF 265
EST09690     278 -ERWSYFIAFGlpst-avsfFHPSGLLNLMLFMLVF 311
GAA90013     204 -RRQLQYTTFG---------TVALILQLIPILSMFF 229
EPB84401     195 -RHRSSYCNFG---------VVAVALELIPLFNLLF 220
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