5JPW,1YGT,2PG1,5WI4


Conserved Protein Domain Family
DLC-like_DYNLT1
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cd21462: DLC-like_DYNLT1 
dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and similar proteins
Dynein light chain Tctex-type 1 (DYNLT1), also called TCTEL1, or TCTEX1, or protein CW-1, or T-complex testis-specific protein 1 homolog, is a non-catalytic accessory component of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. It plays a role in neuronal morphogenesis. It is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1.
Links
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Statistics
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PSSM-Id: 412010
Aligned: 23 rows
Threshold Bit Score: 190.364
Created: 3-Feb-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
homodimer
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:5JPW; Homo sapiens DYNLT1 (also known as TCTEX1) forms a homodimer, contacts at 4A
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                          # #######   ########### #   # 
5JPW_A        14 FVVDEVSNIVKEAIESAIGgnaYQHSKVNQWTTNVVEQTLSQLTKLgKPFKYIVTCVIMQKNGAGLHTASSCFWDsSTDG 93  human
1YGT_A        10 FIVDDVSKTIKEAIETTIGgnaYQHDKVNNWTGQVVENCLTVLTKEqKPYKYIVTAMIMQKNGAGLHTASSCYWNnDTDG 89  fruit fly
2PG1_E        10 FIVDDVSKTIKEAIETTIGgnaYQHDKVNNWTGQVVENCLTVLTKEqKPYKYIVTAXIXQKNGAGLHTASSCYWNnDTDG 89  fruit fly
NP_001037827  12 FVVDDVSNVIKESIETTIGgnaYQHNKVNQWTSNVVEQCLNQLTKLgRSFKYIVTAVIMQKNGAGLHTASSCYWDnSTDG 91  vase tunicate
XP_001742190  12 FSVEDVSAIIKESIDQSIGqssYQHSKVNQWTSNVVEQCLKRLTGLgKPFKYIVHCVILQKNGAGLHTASSCFWDnSTDG 91  Monosiga brevic...
NP_001129255  12 FIVDEVSSIVKESLEAVIGrnmYEHNRVSQWTSSVAEQCLGQLSKLgKPFKYIVTCIIMQKNGAGLQSASSCFWDnTTDG 91  zebrafish
EFX80005      14 FVVDEVSAAIKEAIESVIGgntYLHNKVNQWSSSIMDCCLQSLVKLqKPFKYIVTCVVVQKNGAGVHTSSSCFWDnSTDG 93  common water flea
XP_006008849  12 FVVDDISSIVKDAIESTIGgniYQHNRVNQWTSSVVETCLNQLTKLgKPFKYIVTCVILQKNGAGLHTTSSCFWDnTVDG 91  coelacanth
XP_007892979  15 FVVDDISTIIKEAVESTIGgnaYQHNKVNQWTSTVVEQCLNQLTKLaKPFKYIVTCVIMQKNGAGLHTASSCFWDnSVDG 94  elephant shark
XP_027214759  12 FVVDEVSTIIKESIETVIGgnaYTSAKVNNWTSQVVENVLGNLSKLnKAFKYIVTCVIMQKNGAGLHTASSCYWDnTTDG 91  Streptococcus p...

Feature 1                         # #  
5JPW_A        94 SCTVRWENKtMYCIVSAFGLSI 115 human
1YGT_A        90 SCTVRWENKtMYCIVSVFGLAV 111 fruit fly
2PG1_E        90 SCTVRWENKtXYCIVSVFGLAV 111 fruit fly
NP_001037827  92 SCTLRWENKsMYCIVSVFGLAI 113 vase tunicate
XP_001742190  92 SCTIRWENKtMHVIVSVFGLGI 113 Monosiga brevicollis MX1
NP_001129255  92 SCTVRWENKhLYCIVSVFGLAI 113 zebrafish
EFX80005      94 SCTVRWENKtMYCIVSVFGLAI 115 common water flea
XP_006008849  92 SCTVRWENKtMYCILSVFGLAI 113 coelacanth
XP_007892979  95 SCTVRWENKtMYCIISIFGLGV 116 elephant shark
XP_027214759  92 SCTVRWENKtMYCIVSVFGLAL 113 Streptococcus pneumoniae

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