3CH4


Conserved Protein Domain Family
P-mevalo_kinase
?
pfam04275: P-mevalo_kinase 
Phosphomevalonate kinase
Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway. This family represents the animal type of the enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see pfam00288).
Links
?
Statistics
?
PSSM-Id: 461247
Aligned: 40 rows
Threshold Bit Score: 123.455
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
3CH4_B         16 FSGKRKSGKDFVTEALQSRL--GADVCAVLRLSGPLKEQYAQEhglnFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGF- 92  
CCH63846        7 ISGKRKSGKDYCTNLIREVLvqKRFDVSVAGISHSLKMEFAKKhglkYEELLTDGPYKELYRKDMIQWGEEARCKDSGL- 85  
XP_003100409    8 ISGKRKSGKDYCAKLIKESIasKGVSVSAVGISHSLKEEYAKIhdlnFAELLTDGPYKEKYRKDMILWGEEARNKDFAV- 86  
CAR99325        8 ISGKRKSGKDYCTNNSIKAFekIQLSVSAVGISHSLKEEYAKIhnlnFAELLTDGPYKEQFRKDMIRWGEDVRNKIPSV- 86  
EEU41190      732 VTGESGSGKDYCADIWASVFtmSAIRARTVSISDETKQGYAAAtgsdLRRLLSDRDYKEEHRPALTEFFQEQLKKRSELl 811 
EDW37223        7 ISGKRKCGKDYISERLQKRL---TNRAIIVRISEPIKSEWARKlqldLSALLSDGPYKEQYRRDMIVWSDEVRNKDYGY- 82  
Q16I28         13 FSGKRKCGKDFLTERLLQRL--TTDKAQIIRISEPIKRSWAEKlgldLGELLGDGPYKERYRKEMIEWSDQKRAEDFGF- 89   yellow fever ...
EDS42634       10 FSGKRKCGKDYLTERLLQRL--TPARAQIVRISEPIKRCWADKlgldLGELLGDGPYKERYRREMIEWSDGRRAEDYGF- 86  
Q7PS33          6 LSGKRKCGKDFLADALLQRL--GTDRAQIVRISEPIKRHWAEAmgldLAALLGDGAYKERYRRQMIEWSDGRRQEDYGV- 82   Anopheles gam...
ETN65625       17 VSGKRKCGKDYLSDALLKRL--GHNRAQILRISEPIKRYWATQkglnLDELLSDGAYKENYRKEMIVWSDEQRHEDYGV- 93  

3CH4_B         93 ---FCRKIVEGISQ---PIWLVSDTRRVSDIQWFRE-AYG 125 
CCH63846       86 ---FCRAAISSTmd--sDIVIISDCRRRTDYEYFSA-NYR 119 
XP_003100409   87 ---FCRAAIKSVid--sDVVIVSDCRRLTDYAYFNS-NFN 120 
CAR99325       87 ---FCRAALLSVdd--sDIVIVSDCRRITDLEFFVRtIKL 121 
EEU41190      812 kehFLKAMKNLad---vDVLMITGMRDEAPLVTFSP-LFP 847 
EDW37223       83 ---FCRAAMEEAPLdqiAYVIVSDVRRKNDIKWFRE-TYG 118 
Q16I28         90 ---FCRQACLAla---kEICVVSDIRRKTDVRFFRE-QYG 122  yellow fever mosquito
EDS42634       87 ---FCRAACSEGVVaarEVCIVSDVRRKTDVRFFRE-TFG 122 
Q7PS33         83 ---FCRAACATid---rPICIVSDVRRQTDVRYFRE-AYG 115  Anopheles gambiae str. PEST
ETN65625       94 ---FCREACRTmn---rEICIVSDVRRRTDVRFFRE-TFK 126
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap