Conserved Protein Domain Family
TMEM65

?
pfam10507: TMEM65 
Transmembrane protein 65
MEM65 is an intercalated disc protein that interacts with with connexin 43 (Cx43) and is required for correct localization of Cx43 to the intercalated disc. It is essential for cardiac function in zebrafish.
Statistics
?
PSSM-Id: 463123
Aligned: 46 rows
Threshold Bit Score: 105.268
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EED90065          28 HQSIPFVGFGIMDNSILLLAGEAIDTTLGVTLGISTMCAAAIGNIISDVVGVAFGTVIEDAIARwsgrierlsngkVKLp 107
jgi:MICPUN_74385   2 FNAVPFVAFGFIDNTVLIYAGDAIDNSVGVAFGLSSLAAAAMGQIFSDTSGVLFGGAIEAWVLR------------AGF- 68 
XP_003058461       2 FSAVPFVAFGFVDNTVLIHAGDAIDSTFGVALGLSSLAAAALGQIFSDTSGVLFGSTIEGFVLR------------CGL- 68 
CAM65792         668 AAAPPFLAFGMLDNSTLVLAGGAIDNALSGSLGLSQMAAASLGGVVSGVAGIQVHGLAERYTRA---------------- 731
Q57ZW2           303 SASVPFMAFGILDNSIFVTAGDAIDRRCAEAFGLTSMTAAALGGVVSGVAGVQMHGVAERFTQR------------VRLa 370 Trypanosoma...
Q4CY30           292 SSAVPFMAFGMLDNTIFITAGDAIDKRFAEAFGMSTMAAAALGGVVSGTAGIQMHGLAERMAQR------------SRLa 359 Trypanosoma...
Q38AF3           146 VAGLPFVGFGFLDNAMMILAGDAIDNSFGLYFNCSVLTCAAMGNIFSGVLGMQLHGVIEKAVQR------------FNF- 212 Trypanosoma...
CAM44473         165 EAALPFVGFGFLDNSTMILAGDMIDGSLGFYLNCSVLASAAMGNVCSGVLGMQVHGLIDNTVQK------------LNL- 231
Q84X76           163 AAAIPFVAFGFLDNAIMLVAGEEIDHMFGLRLGLSTLASAGLGNAVADVIGVGAAKYIEQAVRW------------LPFv 230 Chlamydomon...
PIC39896         102 inFIPMFVYGCLDEALIIIGGESINNIFSVYNGMSMLASAAVANIIVN---LFLQLPADRWTDI------------LGF- 165 Caenorhabdi...
EED90065         108 PLPKLSHEQRNLRSVRLASQLGCAIGLTVGCIIGMFPLLFF 148
jgi:MICPUN_74385  69 AQPVLTAEQNMMRVTRMTSTAGKVCGVVTGCCLGLLNLLLI 109
XP_003058461      69 AAPSLTPTQQLARGVRVASTLGKVFGVVLGCSLGLVNLL-- 107
CAM65792         732 APPRLTMEQQRSDAYSRATQAGNTLGMVFGLILGMIPLLFM 772
Q57ZW2           371 RVPVLTAAQQKSKARGSATRVGNTAGMLVGLLLGMIPLLFV 411 Trypanosoma brucei
Q4CY30           360 RPPTLTPSQSASASNGSATRVGSTLGMILGLLFGMTPLLLL 400 Trypanosoma cruzi
Q38AF3           213 RVPTLTENQMKGKRVFFAGHIGGTVGIMTGLLLGMIPLLLL 253 Trypanosoma brucei
CAM44473         232 NTPVLSEEQLKDRRVFLAGHLGGTLGIMLGLILGMLPLLFL 272
Q84X76           231 KEPKLNKYQNAMPATQRAKLAGAMLGVFCGCMLGLTPLFLs 271 Chlamydomonas reinhardtii
PIC39896         166 KKPVLSNDQMNTPEYHYASFAAKLSGLWLGLTLGMLPLFFI 206 Caenorhabditis nigoni
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap