2ERX,2ERX


Conserved Protein Domain Family
ARHI_like

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cd04140: ARHI_like 
Click on image for an interactive view with Cn3D
A Ras homolog member I (ARHI)
ARHI (A Ras homolog member I) is a member of the Ras family with several unique structural and functional properties. ARHI is expressed in normal human ovarian and breast tissue, but its expression is decreased or eliminated in breast and ovarian cancer. ARHI contains an N-terminal extension of 34 residues (human) that is required to retain its tumor suppressive activity. Unlike most other Ras family members, ARHI is maintained in the constitutively active (GTP-bound) state in resting cells and has modest GTPase activity. ARHI inhibits STAT3 (signal transducers and activators of transcription 3), a latent transcription factor whose abnormal activation plays a critical role in oncogenesis. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation.
Statistics
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PSSM-Id: 206711
Aligned: 6 rows
Threshold Bit Score: 289.035
Created: 1-Sep-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:2ERX: Human Diras2 binds GDP and Mg2+, defined using 3.5 A contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ######         ### #  #                                               
2ERX_B      3 DYRVAVFGAGGVGKSSLVLRFVKGTFRESYIPTVEDTYRQVISCDkSICTLQITDTTGSHQFPAMQRLSISKGHAFILVY 82  human
AAH74244    7 DYRVVVFGAGGVGKSSLVLRFVKGTFRESYIPTIEDTYRQVISCDkSICTLQITDTTGSHQFPAMQRLSISKGHAFILVY 86  African clawed frog
AAF54453   18 DYRVVVFGAGGVGKSSLVLRFIKGTFRESYIPTIEDTYRQVISCNkNICTLQITDTTGSHQFPAMQRLSISKGHAFILVY 97  fruit fly
AAI03169   36 DFRVVVLGSAGVGKSALVQRWVRGNFREAYLPTIEDTYRQALGCShKAGALHITDTTGGRRYRGLQRLAIARGHAFILVY 115 cow
CAG46690   37 DYRVVVVGTAGVGKSTLLHKWASGNFRHEYLPTIENTYCQLLGCShGVLSLHITDSKSGDGNRALQRHVIARGHAFVLVY 116 human
2ERX_A      3 DYRVAVFGAGGVGKSSLVLRFVKGTFRESYIPTVEDTYRQVISCDkSICTLQITDTTGSHQFPAMQRLSISKGHAFILVY 82  human
Feature 1                                        ## ##                          ###           
2ERX_B     83 SITSRQSLEELKPIYEQICEIKGdv-eSIPIMLVGNKCDESp-sREVQSSEAEALARTWKCAFMETSAKLNHNVKELFQE 160 human
AAH74244   87 SITSRQSLEELKPIYEQICQIKGdv-eSIPIMLVGNKSDESq-nREMDSSEGEAMAKKWKCAFMETSAKMNHNVKELFQE 164 African clawed frog
AAF54453   98 SVCSKQSLEELRPIWALIKELKGadipNIPVMLVGNKCDETaelREVSQAEGQAQATTWSISFMETSAKTNHNVTELFQE 177 fruit fly
AAI03169  116 SITRKQTLEELKPLYELIRQLKGnnpqKCPVILVGNKCDESr--REVSEKEGAAYACEWNCAFLETSAKMNINVQELFQL 193 cow
CAG46690  117 SVTKKETLEELKAFYELICKIKGnnlhKFPIVLVGNKSDDTh--REVALNDGATCAMEWNCAFMEISAKTDVNVQELFHM 194 human
2ERX_A     83 SITSRQSLEELKPIYEQICEIKGdv-eSIPIMLVGNKCDESp-sREVQSSEAEALARTWKCAFMETSAKLNHNVKELFQE 160 human
Feature 1           
2ERX_B    161 LLNLEK 166 human
AAH74244  165 LLNLEK 170 African clawed frog
AAF54453  178 LLNMEK 183 fruit fly
AAI03169  194 LINFEK 199 cow
CAG46690  195 LLNYKK 200 human
2ERX_A    161 LLNLEK 166 human

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