Conserved Protein Domain Family
Ecm29

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pfam13001: Ecm29 
Proteasome stabilizer
The proteasome consists of two subunits, and the capacity of the proteasome to degrade protein depends crucially on the interaction between these two subunits. This interaction is affected by a wide range of factors including metabolites, such as ATP, and proteasome-associated proteins such as Ecm29. Ecm29 stabilizes the interaction between the two subunits.
Statistics
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PSSM-Id: 463769
Aligned: 109 rows
Threshold Bit Score: 230.913
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q01D85         12 IERAMTSLALTSD-DDLERTLDRALPAIVTSLKTKFPNnlnlLMSMLKHVNARLRGCPNAKLPWKTLIETFAGAEHA-FV 89   Ostreococcus ...
EDV23342       11 LERLLLRFGLAEKdEQLEKELHKFLPSILLKLSHPDEDvrkkVLELLNHVNKRIRNQTDIKLPLDALLDQFQDDATPsFV 90  
XP_004988975   13 LDRVLMRFATAATdEALEQNVRNLLCPMLLKFSSPHQSvrakLMQVLTHINKILGSRSAMQLPVTPLIQQYINKDVSgSV 92  
EPB88095        8 LENVELKLAMCNIdAQLEKTIQIFLPPVLLKLASTNAEakkkVMEILSHINKRVKTNDKIKLPFDALLSQFTDASVStFV 87  
OWR52441       20 LDRVFLRLGNANTdEQLENCLNRFLPPVILKLSSPHEQirtkVMELLIHVNKRVKCRNEVQLPVETLLQSYKDPNANsFI 99  
EDX06719       12 LERVLLRLGNADSdEKLEAAVGKFLTPVILKMNSPHNA----VVEVLTHIKRRLSSRGHVQIPVEALLDQYAAQDSStFL 87  
ETN64681       12 LERVLLRLGYADTdEQLQTTITKFLTPVLIKITSPNENvrkkVMEILTHINKRLKSRNQIQIPLAPLLAQY-QQANSlFL 90  
EEB19460       11 LERVFLRVGSADSdEQLESAINKFLIPVLLKLSSPNEGvrkkVMELLVHINKRVKRQPTVQLPVEALLLQYRDPKATsFF 90  
XP_008186485   13 LERVFFRLGSADTdAQLSACINNFLVPVLQKLSSPHESvknkVVELLTHITRVIKQSPSILLPVDQLVTLL-STSTNnFV 91  
EGI65578       11 LERVFLRLGSAETdEQLQASVCKFLPPVLLKLSSGQEGvrkkVMELLIHINKRIKSRPQVQLPVEALLLQYQDPSASsFV 90  
Q01D85         90 RNFALVYVEKALEREDGRTREIACARLMKGLG-----TRSSDQMDVLCRLAFDSLG------EL---------------- 142  Ostreococcus ...
EDV23342       91 QNFTTVYLKMGFTRLSLADQLQIVPRLFECIT-----SKTAAQQDRVFQLIVPLFS------EL---------------- 143 
XP_004988975   93 KKFTRIYLTMGLSRLPDDDLCTGLLTLLHNIEhcpdpALVYRHVIPALPLLIKGIKpenvleHLgcasatthaagtssdk 172 
EPB88095       88 KNFTLMYLEMAASRLSPEETAHHVPEFLRGIS-----NRPVQQRIPLLHIVLPVLI------KW---------------- 140 
OWR52441      100 INFSIIYITMGFPRLPKDRQVDLVPSLLEAIE-----NKPVAHQDSILMLVMPLLG------DI---------------- 152 
EDX06719       88 KNFAIIFITMGFPRLAVEQQTALASKVVGC-E-----DKLESYQDKLFALLLPILS------DI---------------- 139 
ETN64681       91 INFAIIYITMGFPRMTVEEQTEMAPVLLNCLE-----GKPETHQDKILMLVLPLLG------EI---------------- 143 
EEB19460       91 INFSILYIKLGFPRLPPSKQEELAPILLLATE-----GKPKIHQDSLLLLLTSIIG------NV---------------- 143 
XP_008186485   92 LNFTVVFVKTSFGRIDNNKKVELIPSLINSIA-----NKSISHQESILLLIIGVLN------KS---------------- 144 
EGI65578       91 INFTIIYIKLGYPRMELNKQAELVPSVLNAIE-----GKPLSHQDSLMLIIMPALG------HI---------------- 143 
Q01D85        143 --R-VS---DAERDC-----EWLRD--AATRGAFLQRARDFLAYspNAAGTsaattpnrlethvealanaaigvddarag 209  Ostreococcus ...
EDV23342      144 --K-EK---YSVEELrr-miGIADNklSNTGSSLLQYLLDLLSM--PYSPQidlak------------------------ 190 
XP_004988975  173 dkTaPSpptEQHQQQqqqqqD--GPtvQRRRQQLVEFARDFLLLntAALQLihpqqegs--------------------- 229 
EPB88095      141 --K-MDh-gEQLTARta-lfHFDEN--PNDIPVILSFFLDVMLYq-Pltareiaeq------------------------ 188 
OWR52441      153 --Ket-------------nlKLKEK--PKVANLILKFATDILLL--PYRALpnsges----------------------- 190 
EDX06719      140 --K-IP---DDPEQRsk-llDLQDK--PAICANFLALLQDVLLL--PYGITqeq-------------------------- 182 
ETN64681      144 --K-IP---ENPENRse-llGLSNK--PHTKQQLLSILMDVLLL--PYGTLpds-------------------------- 186 
EEB19460      144 --K-VP---NDVEKKkd-lfKMNEK--PELMKHFSSFMLDMLLL--PYVHIssndeessp-------------------- 192 
XP_008186485  145 --N-VQ---VA---Skg-iiVIQQN--PTLKTVILQLMLDVLLL--PYKWSgsde------------------------- 185 
EGI65578      144 --N-IP---ADPDKRas-llGLQDK--PYVAKQLINFMLDILLL--PYGSVgqtenqqgsgq------------------ 194 
Q01D85        210 elraaavassaaraedaaapvlsapPSMSPSAVERLLgKGKpk-pAPA--VLAKKKLRVLDYIASASvmeksesadvsme 286  Ostreococcus ...
EDV23342      191 ---------------------legaPCLSAASIKRII-PEG----GINpdQLEKMKLGILKFLATDL------------- 231 
XP_004988975  230 ------------------talppppPGLSRTRLLALVdQKGavfrCPTreDVHALKLAVVDVL----------------- 274 
EPB88095      189 ----------------eeentapnyPGLSPLAVEEVTnKGKiq-wTTSk--LKDAKLGIMNLILTPI------------- 236 
OWR52441      191 --------------------efqvpPGMSMKSYKRIV-DKN----QINpnQLEEMKLSIVNFIGKDV------------- 232 
EDX06719      183 ----------------------dvpPGLSPYSFTRVI--AY----NWRaeELEKVKKGIVRFLCASV------------- 221 
ETN64681      187 ----------------------dvpSGMSVYTFKRVT--VK----PPKaeELEQLKKGIVRFLCGGI------------- 225 
EEB19460      193 ----------------svpsniqppPGMSESGFKRVTsGDT----PMTpeRLEQTKLGIVKFLATGV------------- 239 
XP_008186485  186 ----------------------vpvPGFNTQSLKRLR-LNIpl-iFMDadYHEQVKLGILGLISANI------------- 228 
EGI65578      195 ---------------tidwsqftvpPGLSDYAFKRVI-GES----PPTaeQLEQIKLGIVKFLTGGF------------- 241 
Q01D85        287 sdeeskaelqtprerflVSGR--------EMLSICLIASCDSDHEVAKRGEELLKRRCSwetnrpviNLDDADVADELFQ 358  Ostreococcus ...
EDV23342      232 -----------------FTET--------AIAPHLIIASGDARWSs--------------------iDWESAQLITILYQ 266 
XP_004988975  275 --------------------SqpktfharDVAVALMTAAGDPNSDIADRAVLGMRRVGV--------DLNDPPTVVSIMQ 326 
EPB88095      237 -----------------FTDS--------ERLPLLVAGVCDPNHQVVSACEDGMRRWTGn------vDYEDDATIKSLYK 285 
OWR52441      233 -----------------FSAS--------EALVPLVVAAADSRFSVANHANSPLIRVNSs------vDWSQQSVVAPLYS 281 
EDX06719      222 -----------------FSDL--------QIFVPLVVASADTRFSVATPAITELSKLCTm------lDFSNPAVTAPLYT 270 
ETN64681      226 -----------------FPDP--------EILAHLVVASADTRFSVATPAIGELNKICSs------lDWTDPKLSAPLYT 274 
EEB19460      240 -----------------LSNN--------DIICHLIIAAADTRFTVANLADAELKKVASs------vDWSSVAVASRLFY 288 
XP_008186485  229 -----------------FESQ--------SVLVHSVVGAADTRYMVANSGGNELRKITCe------iDWSKSSTMMPLYA 277 
EGI65578      242 -----------------FPDT--------DILIHLIVAAADTRFSIANMADLELKKMIGt------lDWSSMQLAAPLYT 290 
Q01D85        359 LFNGSpm--------giPEASRILPASPSVRLKIMTLLTRSM-AAADsFPQNIetVKMCLYGVG-TNT---RLKACGMQF 425  Ostreococcus ...
EDV23342      267 LYLGSsmktlsktqtiiKPEEQRIPANNRVKLLIIPLLIKSN-KAGDeFPPCMqvIFDALNAPT-TTQ---RLKTFALQF 341 
XP_004988975  327 YFT-Lspssp--aqkalPVDARRTLMSARARSAIAARLVRSV-AAPKaVPACLacVF----SCIyDNAgdaRLRSLGLQL 398 
EPB88095      286 LYLGSkpta-----kaaNKDG-RSQAPNSVKLRILQYLSKSV-AATNmVAPMIqvIFDGIYGDL-TTT---KLQRSAMSF 354 
OWR52441      282 LYLGTwgg------mtvHPDDRKIPACTRLRLKLIQYLNKAT-GPAIiFPHCVqvVFSSIFVTN-TNS---RLRNMALMF 350 
EDX06719      271 LFAGNqs---------kLTDRQTRPCCARVRQKLLQYLIKCR-GKSInVTKGLqvTFDGFFGTN-TNQ---KCKVLALQF 336 
ETN64681      275 LFTGNgs---------kIPDRKTSGVSARVRQKLLQHLLKCR-GNGIiTARGMqvIFESLFGEV-TNQ---KCKVLALQF 340 
EEB19460      289 IYLGSpevppe-krniiPPANRVVPANTRIRLKILPYLSRLE-KDAVlFPGSVqiIFSSLYDVN-TNA---KLKLQALNF 362 
XP_008186485  278 LFLGTsln------kqgA-ANKKEPACVRIRLKILPCLCFSKsEESViWPQCMqiIFDCWNGEN-TNQ---RLKNLALQF 346 
EGI65578      291 LFLGTdalat---qkevKPEMKRLPASTRIRLKLLQYLCRVT-KAGFiIPPCIqvIFDSLYGKN-TNA---KLKSLALQF 362 
Q01D85        426 TVWILTHATSKELLAFGPSLM-AGMLEILDaQVEGANedqssTlaresLRGFCYQALSQLAERDKAS---VNRDVLLAER 501  Ostreococcus ...
EDV23342      342 MGHVCKKSSNTKIKIMGPILF-SSLKKLI--SSEKES-----I-----LRQLSYHNCGYLSKRLPNM---FAKDVGIVVQ 405 
XP_004988975  399 MGRMLHFSPQQQIAPLCPLLF-DRTLKLVDdpsn-----------tleVYGHAYHNLGLLARKSDAMrvrVRDDVALLRK 466 
EPB88095      355 LQWCARMSKESSIGPVAPVIV-SGLLKYINeNEETQGy---dAe---sIKGYAYIACGLVAKKVPKV---GLEDTHMLSL 424 
OWR52441      351 LLNVINNGNEVQLRQVASVFL-QGLLKLI--RTEEHA-----E-----QHAKAYMCLGRLAMKCPSC---FNNQFALLEE 414 
EDX06719      337 MELVLREGPRELVSKVSKVIL-TGITKIIGrDSNEPN-----E-----VQNAAYSALAQHARSFPQD---VSQDLKLVLG 402 
ETN64681      341 AYNLINHGDPDLINKLSQVLL-TGIAKLIGtSSEESI-----E-----VQNAAYSALAQLAIVCPTT---VNQDIQLVGE 406 
EEB19460      363 ALAIVRKSEIQNLKKMAGMLY-SGLLKLVW-NEEENE-----Q-----LRVVGYTVIGQIVKRMPRI---INKNLIELQA 427 
XP_008186485  347 TQIIIQQKPAKILLQATPILLnSGLLKLLK-SPELDL-----N-----AKQMTFTLIGLLISKVPSS---VKEDLVLLNS 412 
EGI65578      363 TSNIVQHCSLVPLTRVAGVIL-NGMIKLIS-EGDDMH-----K-------PMAYTVIGQLGQRIPSL---INKDLSLLHN 425 
Q01D85        502 IFEALEKEPE-GVKSYVQDAARTLVAAY--Re---------------------------------sPSTYVQTRTEELIL 545  Ostreococcus ...
EDV23342      406 FFNALTEEDA-DSKSALRDALIDMASCY--Ks----------------------------------VSETDATMLENLLL 448 
XP_004988975  467 LFQRCAGAAg-NLVLHLQEALALMKECY--Ig----------------------------------vSGDNARRLVNLLL 509 
EPB88095      425 FFDNLEQEQK-NVRTYVQDALSSMIEIY--Vdi--------------------------------aPDAPIYDDLQQIIL 469 
OWR52441      415 LVKKIPDAVP-EIKTALRDALLEMATAY--KitpedkgepmeceeagpsgveaaeggeskkprpspFDEPHALALFALLD 491 
EDX06719      403 YFNNLASCAP-ELHSSIREALVSMAPAF--Awktkeksdame-------------vdehvdsssvkL-DGQQHLLLAMLL 465 
ETN64681      407 YFNHLQQAPV-DMQSSIREALVALAQAF--Dwrkqpqpaataame--------tddgatkqqprlfVPNANQNLLLALLG 475 
EEB19460      428 FFKNLTSEST-EIRGAVRDSMLTMIDAF--Klfmke--------------------------dkadPKSNGQFFMLALLT 478 
XP_008186485  413 FFDALIKETSpDLKGSIRSSLISMCNAY--T------------------------------------DSSKLTDILNMIA 454 
EGI65578      426 LFDTLVSTDG-ELRRTVRDALICVTSAFvlNk----------------------------------eDESNIALMNALL- 469 
Q01D85        546 SAIeDKDNKYRRLVGAQWAHEFFPFSHVPSRYASVI 581  Ostreococcus tauri
EDV23342      449 QYV-EHTILPCRLLSVRLANIIFPTDNVTSRYVCIL 483 
XP_004988975  510 EHV-VHTQSAVRTMAVRYAVDVFPPDHVSSRFVLIL 544 
EPB88095      470 KAV-QKSDSYSRYMALKYANAIYPFSSVFARYVCLL 504 
OWR52441      492 HYM-HCEESMIRYIAMRYASAVFPQDYVPSRYLLLL 526 
EDX06719      466 DNA-ESKVQIVQNVTSVFLTSCYPEYYAPARYLLLL 500 
ETN64681      476 EKA-ESKMPIVQNVASVFLTTCFPDYFVPSRYLLLI 510 
EEB19460      479 AQS-QSPESMARFVAVKYIAAAFDFDHVPSRYLLLL 513 
XP_008186485  455 HYC-KMSDGLLKQVTTHYLSYLFPADDAKSRLLLIV 489 
EGI65578      470 ------------FVAMHYAATVFPPDDAPSRYLLLL 493 
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