Conserved Protein Domain Family
HAUS-augmin3

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pfam14932: HAUS-augmin3 
HAUS augmin-like complex subunit 3
This domain is subunit three of the augmin complex found from Drosophila to humans. The HAUS-augmin complex is made up of eight subunits. The augmin complex interacts with gamma-TuRC, and attenuation of this interaction severely impairs spindle MT generation. Furthermore, we provide evidence that human augmin plays critical and non-redundant roles in the kinetochore-MT attachment and also central spindle formation during anaphase in human cells.The HAUS complex is required for mitotic spindle assembly and for maintenance of centrosome integrity.
Statistics
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PSSM-Id: 464384
Aligned: 38 rows
Threshold Bit Score: 165.181
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_019206198         29 WLFDCpPENLHFLRFVCRTLNQSNVLTPEEARAFQELQ-KSGKPILDETALSEVLKTIG---NSDGSTgnilGSSSSssm 104
EDV22559             32 WLFEE-DSMLSFLAWLADSVDNNNVLSSEEKDRFEKLVtEKGEKVLRGRDLEAALQTIDq-----------tDQETQide 99 
ETN61091             23 WVVHD-ENFRDFFDWFAK-VDDDNLITDALDKDYDELK-RHDD-VYEESEVDALLKQLDtqySNILDYt--dRDVTEleq 96 
XP_002074800         22 WILYD-EQFERFFNFISENITDANILTEQELLERDEMV-LNGN-WLDKPECELALRRIDaenPGLLKHk--pQNVTAlss 96 
EDW32833             22 WLLYD-EKLEKFFKYLSVSITDSNILTEQEVLERDEMQ-HRAN-WLTGSELQLKQQEIEaenPGLLTHt--qQDVDAlsa 96 
WGS:AAPP:GF12731-PA  22 WILYD-EQLEKFFKFLSQDVTDANILTESQVLEREEMR-RRNE-WLEESDRELKLLQIEsesPGLLKFn--rQDVSGltm 96 
Q9W2P0               22 WILYD-EQMEMFFKFLSGNITDANILTERQVLEREEMQ-RRGE-WLSASDRELKLLQIEaesPGLLNYk--qQDVDAltm 96  fruit fly
XP_002055549         23 WIVYD-EQFEKFFNFLSENVTDSNILTARELLERDEMM-QRGE-WLQESERILKLQQIEsenPGLLKYt--nQDVETlaa 97 
WGS:AAPU:GI15999-PA  22 WIIYD-EQFEKFFNFLSENITDSNILTEREVLESEEMK-QRGA-WLKESERVLKLQQIEsenPGLLKYt--aHDVDAlal 96 
XP_314793            23 WIIHD-ETFREFFDWFTK-IDDDNLVTDMLLKNYQELD-RNGT-VLNDALLEEQLHALNhefSGILEHt--dRDVEAlel 96  Anophele...
XP_019206198        105 faAEedfpIEDLEAELQALRKEKELKQRRYNKLQVVATSRADVDLRFTAELESTSRKLNETNSSIGAENADTNTLLQTLT 184
EDV22559            100 seDLlradLHALRKEIATAKAYKAKIINHRNALNIHQISLSHKLDPLVDLNNLKRQENNNIAQENEEANKKVNKSLQMIT 179
ETN61091             97 qlEQmveiEEHYERLLEDAKKTDILLTKELTDIERATIDAQYLMEKQEKSCLTLGKRLEENQLITQQKIADLHHCYLQPQ 176
XP_002074800         97 eiAVledaAHEYAVLIDDMQNSKRIITNNLNNLEYEITKLQNEGRGLIASSQTRAKQLEDLQRENCKLSIEAKKGFTSQQ 176
EDW32833             97 vgAAiqeaSADYASLIENMANTKQTINNNLIELECAASALQNTEKILLSDCQEKAKQLEELQSENCKLSSEAKKAFISEP 176
WGS:AAPP:GF12731-PA  97 eiASieeaSRDYALLLEDMLNAKHSITNHLSELECAACELQSKEKELLSECQSKAKQLEELQRENCRLSGEAKKSFTTPQ 176
Q9W2P0               97 siEAiedaSRDYATLLEDMMTTKHSITKHLGEVECVTAELQLREKDLIAECQSKAKQLEELQQENCRLSAEAKKAFTAPQ 176 fruit fly
XP_002055549         98 avEVieeaTNDYSTLIDEMQNTKHSIISKLSELESTILLLHNTEREMLVECQAKARQLEELQRENCKLSEDTNKGFTLPQ 177
WGS:AAPU:GI15999-PA  97 evEAikeaTKDYCILIDEMQNTKHSQSSKLSELECTILSLSNGERELLGECQAKARLLEEVQRENAKLSEEANKGFTMQQ 176
XP_314793            97 qlEQlvevEEKYEKLLNGAKKTDLALTKELSELERSVRDQEYVLEKVATNSVEMARQLEESQQATQQQISDLQHCYYQRQ 176 Anophele...
XP_019206198        185 DEVGNLASYFPVQpqakpkgkdhtdppvsqrPTFLLSQLSLDPYLHQEELNTKALAAFTQKHFFQGISAIVESSCSERFQ 264
EDV22559            180 QNVRSLAQLYDAD------------------NPPFLYQQSLSDYHASTEKFLRTLTNFIKKQFFEGISEIVGPENESYYQ 241
ETN61091            177 N------------------------------PPLFVYQMPIEQFDAKCDQFLKYLQMYVKKHFP--VRHLEGFK------ 218
XP_002074800        177 S------------------------------PPVFMHQQPLEQYFLKNDSFVQYFNLYLKENFK--IQDNQDFQ------ 218
EDW32833            177 M------------------------------PQLFMHQLPLEHYFLKCDSFMQYFTLYIKENFK--IQKNNEF------- 217
WGS:AAPP:GF12731-PA 177 M------------------------------PPLFMHQLPLEQYFLKCDSFMQYFTLYVKENFK--IQEYDEF------- 217
Q9W2P0              177 L------------------------------PPLFMHQLPLEQYFHKCDSFMQYFTLYVKENFK--IQDYDEF------- 217 fruit fly
XP_002055549        178 V------------------------------PPLFMHQMPLDQYFLKCDSFMQYFTLYMKENFK--IQELIDF------- 218
WGS:AAPU:GI15999-PA 177 S------------------------------PPLFMHQMPLEQYFLKCDSFMQYFTLYMKENFK--IQEFTEF------- 217
XP_314793           177 N------------------------------PPLFIYQMPIDQFDAKCDQFLKYLELYVKKHFT--VKRLDNSK------ 218 Anophele...
XP_019206198        265 VLDLSSCEDgkeeengHEGEERlvdrrRTEMARLQWSHIVAQHQLMQAMAE 315
EDV22559            242 LLDINNPLEel----lRGKSEErysqeRQELSRLQQIYPLSKLQQIKAKAR 288
ETN61091            219 -----------------SSTELsnsevLDELEDIKLRLDVEELKLLEEKRE 252
XP_002074800        219 -----------------NSLVDdmevaNSNLEVLQNSLEFYTIAIIKKKIK 252
EDW32833            218 -----------------STAEVnilheKEKLESLERGIQYYALAFIKKKAK 251
WGS:AAPP:GF12731-PA 218 -----------------QIAENdflheKHKLEDLQNGIQHYALSYIRHKAK 251
Q9W2P0              218 -----------------QSAEEdlgreKAKLEDLERGIQFYALSYIRTKAK 251 fruit fly
XP_002055549        219 -----------------ESAEVdvqhfNSKLENLQNSIQYYTLEYIKEKAK 252
WGS:AAPU:GI15999-PA 218 -----------------EDAEVnmqhfNSNLENLQKSIQYHTLEYIKEKAK 251
XP_314793           219 -----------------STDDGdnqqvIDELEGIKMRLDEEELKLLEAKRE 252 Anopheles gambiae str. PEST
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