3D3F,3B3D,3F7J


Conserved Protein Domain Family
AKR_AKR5G1-3
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cd19157: AKR_AKR5G1-3 
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AKR5G family of aldo-keto reductase (AKR)
Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Links
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Statistics
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PSSM-Id: 381383
Aligned: 16 rows
Threshold Bit Score: 451.075
Created: 18-Apr-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic
Conserved site includes 29 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3D3F: Bacillus subtilis YvgN in complex with cofactor NADPH, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    ###                       #    #                            #    
3D3F_A      7 TVKLHNGVEMPWFGLGVFKvengNEATESVKAAIKNGYRSIDTAAIYkNEEGVGIGIKESGv----aREELFITSKVWNE 82  Bacillus subtilis
O34678      8 KATLHNGVEMPWFGLGVFQveegSELVNAVKTAIVHGYRSIDTAAIYgNEAGVGEGIREGIeeagisREDLFITSKVWNA 87  Bacillus subtilis ...
AIF49800    8 TVTLANGVKIPWLGLGVFKvkegREVVDAVRTAITSGYRSIDTAAIYgNEEGVGQGIKEGLkeagisREDLFVTSKVWNA 87  Pelosinus sp. UFO1
AMN32445    8 TITLNNGIEMPRVGLGVFRvdnsSELVNAVKVAIKNGYRSIDGAAIYgNEEAMGEGIREGIkesgisREDLFITSKVWNA 87  Clostridium perfri...
SHE13961    8 STELSNGVKMPWLGLGVWRveegQVVENAVRSALKIGYRSIDTAAIYgNEQGVGKAVAESGi----sREELFITTKVWNE 83  Chlamydophila abortus
NP_348579   7 FTVLNNGVKMPWLGFGTYKieyeESSVDYIKTALKVGYRHLDTAAVYgNEPIVGKAVKESGi----pRNEIFITSKVWNN 82  Clostridium acetob...
CUN70746    5 CVTLNNGIKMPILGFGTFKvedaQQTIDAVKCALELGYRHIDTATIYqNEEGVGQAIKESGi----pREEIFLTSKVWNS 80  Turicibacter sangu...
OUT55236   10 SFELHNGVQMPYFGLGVYLskdgSEVINAVKEALNHGYRHIDTAAIYnNEEGLGKGVQESNv----dRKDIFLVSKVWNT 85  Muricauda sp. TMED12
SLL36233    8 TTTLHNGVEMPWLGLGVFLvkdgEEVVNSVKAALEAGYRSIDTAAVYkNEEGVGKAITESNv----pREELFITTKVWNA 83  Mycobacterium absc...
ACZ07473    3 SLKMANGVEIPQIGFGTFKip-dDIAAQSVKYALAAGYRHIDTAAVYrNEDGVGLGIKESGi----pRNEIFLTSKLWND 77  Sebaldella termitidis

Feature 1                                 ##                             ##                   
3D3F_A     83 DqGYETTLAAFEKSLERLQlDYLDLYLIHWPgk--dKYKDTWRALEKLYKDGKIRAIGVSNFqVHHLEELLKDAEIkPMV 160 Bacillus subtilis
O34678     88 DlGYEETLAAFETSLSKLGlDYLDLYLIHWPve--gKYKEAWRALETLYKEGRIKAIGVSNFqIHHLEDLMTAAEIkPMI 165 Bacillus subtilis ...
AIF49800   88 DqGYESTLAAYTASLKRLDlDYLDLYLIHWPvk--gKYKETWRAMETIYNEAKVRAIGVSNFhVHHLKDLFQDFKIkPMV 165 Pelosinus sp. UFO1
AMN32445   88 DlGYESTIAAYEASLKRLGvDYLDLYLIHWPve--gKYKEAWRALEYLYKEGHVKAIGVSNFqIHHLQDLLKDAEIkPVI 165 Clostridium perfri...
SHE13961   84 DqGYDKTLKAFEESRRKLGlEYVDLYLIHWPgk--dKYKDTWKALEKLYKEGLVRAIGVSNFhIHHLDNLLADAEVvPMV 161 Chlamydophila abortus
NP_348579  83 KhGYDKTLKAFEDTLKRLDtDYLDLYLIHWPk---tLNKETWKALEKLYKDGRVRAIGVSNFkVHHLEEILEDCEIvPMV 159 Clostridium acetob...
CUN70746   81 DqGYESTLKAFETSLKKLQtDYLDLYLIHWPk---aLNHETWRALEELYNQGRIRAIGVSNFkEHHLDNLLEVATVlPAV 157 Turicibacter sangu...
OUT55236   86 DqGYDATLKAFDASLERLGtDYLDLYLIHWPkg--eLSKETWKALEKLYKEKRVRAIGVSNFlQHHLEDLLTSAEIvPMV 163 Muricauda sp. TMED12
SLL36233   84 DqGYEATLAAFDVSMEKLGlDYLDLYLIHWPlpsqgKFVETWKALEKLYKDGRVRAIGVSNFkVHHLEEVIAKGEIvPMV 163 Mycobacterium absc...
ACZ07473   78 DqGYDSTLKAFDVSLKKLGtDYLDLYLIHWPk---nKNKESWKAMEKLYKDGRVKAIGVSNFkEHHLDDLLTDAEItPMI 154 Sebaldella termitidis

Feature 1      #                         #######   #                #              ######  #  
3D3F_A    161 NQVEFHPRLtQKELRDYCKGQgIQLEAWSPLMQGq-lLDNEVLTQIAEKHNKSVAQVILRWDLQHGVVTIPKSIKEHRII 239 Bacillus subtilis
O34678    166 NQVEFHPRLtQKELIRYCQNQgIQMEAWSPLMQGq-lLDHPVLADIAQTYNKSVAQIILRWDLQHGIITIPKSTKEHRIK 244 Bacillus subtilis ...
AIF49800  166 NQVEYHPRLvQKELRAFCKEQgIQFEAWSPLMQGk-lLDNPTLQEIANKYGKSIAQVIIRWDLQNGVVTIPKSIKEHRII 244 Pelosinus sp. UFO1
AMN32445  166 NQIELHPYLsQEKVREFCKENdIQVEAWSPLMAGnglLENDVLKEIAKKYNKTTAQVVLRWGLQSQVITIPKSTNEGRLI 245 Clostridium perfri...
SHE13961  162 NQVETHPLLsQKELLQYCKEHrIQMEAWSPLMQGn--LDHPVLKEIAAAHGKSPAQIVLRWDLQNGVVVIPKSINEHRIK 239 Chlamydophila abortus
NP_348579 160 NQVEYHPQFpQTEVHEFCKKNkIQLESWGPLMQGk-iFDIPLMKELSLKYGKTISQIALRWDLQMGVVTIPKSINENRIK 238 Clostridium acetob...
CUN70746  158 NQVEYHPRMmQTSLAKYCKERgIQLEAWGPLMQGk-vFELDLLNDLAQKYNKTIAQIVLRWDIQNGIVTIPKSVHPDRIK 236 Turicibacter sangu...
OUT55236  164 NQMEFHPYLvQQDLIDFCKSKeIQYEAWSPLMQGn-iFDLDIMKNLASKYNKTIAQVVLRWDLQKGVVTIPKSSKKERII 242 Muricauda sp. TMED12
SLL36233  164 NQVEYHPRFnQRELHDFCKKHsIQLEAWSPLMQGg-lLEEPTLVEIAKKYNKSTAQIIIRWDIQTGVVTIPKSVKPHRIA 242 Mycobacterium absc...
ACZ07473  155 NQVELHPQFpQEALRNYCTKKgILTEAWGSLMQGq-iFDKELIKEIAQKHNKTVSQIGIRWAVQNGVVTIPKSTHEQRIK 233 Sebaldella termitidis

Feature 1     ##                              
3D3F_A    240 ENADIFDFELSQEDMDKIDALNKDERVGPNPD 271 Bacillus subtilis
O34678    245 ENASVFDFELTQDDMNRIDALNENLRVGPDPD 276 Bacillus subtilis subsp. subtilis str. 168
AIF49800  245 ENSNVFDFELTKEDMEQIDALNQNQRVGSDPD 276 Pelosinus sp. UFO1
AMN32445  246 ENIDIFDFNLSKDDMDRIDSLNKDLRVGPDPD 277 Clostridium perfringens
SHE13961  240 ENSEIFDFELSAEEMEKIDGMNENKRFGSNPD 271 Chlamydophila abortus
NP_348579 239 ENCDLYDFEISKEDMKKIESLNTGVRIGHDPD 270 Clostridium acetobutylicum
CUN70746  237 GNAEIFDFEISPEDMELINSLNKEERIGPDPD 268 Turicibacter sanguinis
OUT55236  243 ANSDLFDFELSEEDVQLLDGLDNGKRFGPDPD 274 Muricauda sp. TMED12
SLL36233  243 ENADVFDFELSDEDMDKINALNQDQRMFADPD 274 Mycobacterium abscessus subsp. abcessus
ACZ07473  234 DNLNVFDFELDNEDMKKIAELNTGIRIGRDPD 265 Sebaldella termitidis

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