Conserved Protein Domain Family
CART
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pfam06373: CART 
Cocaine and amphetamine regulated transcript protein (CART)
This family consists of several cocaine and amphetamine regulated transcript type I protein (CART) sequences. Cocaine and amphetamine regulated transcript (CART) peptide has been shown to be an anorectic peptide that inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. The C-terminal part containing the three disulfide bridges is the biologically active part of the molecule affecting food intake. The solution structure of the active part of CART has a fold equivalent to other functionally distinct small proteins. CART consists mainly of turns and loops spanned by a compact framework composed by a few small stretches of antiparallel beta-sheet common to cystine knots.
Links
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Statistics
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PSSM-Id: 461888
Aligned: 12 rows
Threshold Bit Score: 105.539
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003452592  38 TQQEKELIEALQEVLEKLKGKQLPsSEKKLGWLAACDAGEQCAIRKASRIGKLCGCPRGTVCNFSVLKCL 107
XP_005798411  40 TQQEKDLIDALQEVLEKLRNKEMP-LEKKLGWLPSCDAGEPCAVRKGARIGTLCSCPRGTACNFYVLKCL 108
NP_001191709  38 TQEEKELIEALQEVLEKLRNKQLPsSEKKLGWLPPCNTSEQCAVRKGARVGKLCGCPRGMECDFSILKCL 107
XP_006002380  38 SQEEKELIEALQEVLEKLKNKRVPsAEKKLGWVPSCDAGEQCAVRKGARIGKLCNCPRGTSCNFYILKCL 107
XP_014956676  21 ASHEKELIEALQEVLKKLKSKRIPiYEKKYGQVPMCDAGEQCAVRKGARIGKLCDCPRGTSCNSFLLKCL 90 
XP_015198580  40 SSTEKELVEAMEELLGKVQS-RFPsYEKKAATIPMCDVGDRCALRQGPRIGKLCDCARGSICNSFLLKCI 108
Q1L893        37 QFIKRDLAEALDELLDGEQDNRIs-LEKKASVIPRCDVGERCAMKHGPRIGRLCDCMRGTACNTFFLRCY 105 zebrafish
XP_005808177  87 PAADRDLVEALEVLLGRIHS-RVSsTEKR-GSIPLCGMGGRCAVKFGPRIGKLCDCGRGANCNSYLLKCI 154
XP_014340364  40 SSAERELVEAMEELLGKFQN-RYPtYEKKGGQIPLCAIGERCAVKQGPRIGKLCDCSRGSSCNSFLLKCI 108
XP_017545137  47 LTSEKQLLGALHEVLEKLQTKRIPpWEKKFGQVPMCDVGEQCAVRKGSRIGKMCDCPRGAFCNFFLLKCL 116
BAJ39823      37 RYNSNRLLGALHDVLERLQTTRINpWEKKYGQVPSCDLGEHCAIRKGSRIGKMCDCPRGAFCNFFLLKCL 106
XP_012716787  43 DGNERQLISDLHQVLERLQNSQFPaLRKKHNYLPVCDPGEQCALRKGSRIGKLCDCLLPRTCNSFLHRCL 112 mummichog
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