Conserved Protein Domain Family
Adeno_IVa2
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pfam02456: Adeno_IVa2 
Adenovirus IVa2 protein
IVa2 protein can interact with the adenoviral packaging signal and that this interaction involves DNA sequences that have previously been demonstrated to be required for packaging. During the course of lytic infection, the adenovirus major late promoter (MLP) is induced to high levels after replication of viral DNA has started. IVa2 is a transcriptional activator of the major late promoter.
Links
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Statistics
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PSSM-Id: 280594
Aligned: 3 rows
Threshold Bit Score: 589.928
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P03272  76 LDRDavehVTELWDRLELLGQTLKSMPTADGL----KPL----KNFASLQellslggerLLAHLVRENMQVRDMLNEVAP 147 Human adenovirus 2
Q9III4   1 MDKR----IEEFYNKIVEWKNAVDRINRSILPecdlPPY----RDFYSYE---------IDCGLEEYMNHFYGIQKLNQK 63  Frog adenovirus 1
Q64749  61 YEEEeyeaSRDFYQRVTSWYDGAVDL----------APQlfreQHFPSYDefys--lggVNEKFLEAHEEVKAQEQMDSR 128 Fowl aviadenovirus 1

P03272 148 LLRDDGSCSSLNYQLQPVIGVIYGPTGCGKSQLLRNLLSSQLISPTPETVFFIAPQVDMIPPSELKAWEMQICEGNYAPG 227 Human adenovirus 2
Q9III4  64 FLSANGELSSLNYGLNPFIGIISGPTGTGKSQLIRNLISNKLISPPPETVIFITPTKGMLSPEETNLWKLQLQEGNYEKN 143 Frog adenovirus 1
Q64749 129 YLQH-GQLPSINMGKQPIIGVIYGPTGSGKSHLLRALISCNMLDPIPETVIFITPEKNMIPPIEQTSWNLQLVEANFDCR 207 Fowl aviadenovirus 1

P03272 228 PDGtIIPQSGTLRPRFVKMAYDDLILEHNYDVSDPRNIFAQAAARGPIAIIMDECMENLGGHKGVSKFFHAFPSKLHDKF 307 Human adenovirus 2
Q9III4 144 TDG-ICPITSVFSVDFVEIDFETAVSPDNLDINNDKSCFVQAAKNGNVCIVIDECMKCLIDKRNISPLFCSLPSKISSKF 222 Frog adenovirus 1
Q64749 208 EDGtIAPKTSTFRPEFMEMTYEEATAPEHLNIDHPDNIYVKVSKRGPVAIIMDECMDKLCSGSSVSVLFHALPSKLFARS 287 Fowl aviadenovirus 1

P03272 308 PkcTGYTVLVVLHNMNPRRDMAGNIANLKIQSKMHLISPRMHPSQLNRFVNTYTKGLPLAI-SLLLKDIFRhhAQRSCYD 386 Human adenovirus 2
Q9III4 223 K--TGFSMFVVLHNINPTSGNGNNIMDLKIQAKLHILSSKNAPFQLSRFVNTYGTGMSPQLkAVLMNSIIE--ESKNDYS 298 Frog adenovirus 1
Q64749 288 AhcTAFYIFVVLHNMAPRTAI-GNVPTLKVNAKMHILSCHIPQFQFARFLYAFAHNISKDL-VVLLKAYFSflQQNQRFS 365 Fowl aviadenovirus 1

P03272 387 WIIYNTTPQHEALQWC-YLHPRDGLMPMYLNIQSHLYHVLEKIHRTL----NDRDRWSRAYRARKT 447 Human adenovirus 2
Q9III4 299 FILFNVEPPRPGFSWCaLLNGGNCCEPLSLDLQSILLECVNKICAILkckkRNRERYVKEKKRKLE 364 Frog adenovirus 1
Q64749 366 WVMYTPDPVSESFRWC-SIDQQYSIIPLNVNIQERFLKTAKSIIKF-----SETHRKQLERNPKLT 425 Fowl aviadenovirus 1
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