Conserved Protein Domain Family
DEXHc_ASCC3_1

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cd18020: DEXHc_ASCC3_1 
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3
Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Statistics
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PSSM-Id: 350778
Aligned: 10 rows
Threshold Bit Score: 344.029
Created: 17-Jul-2017
Updated: 17-Oct-2022
Structure
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Aligned Rows:
 
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of Saccharomyces cerevisiae Mtr4 with bound ADP

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ###  #                   #######                                                
NP_650472     486 ELNRIQSVVFPVayhsNENMLVCAPTGAGKTNVAMLSIVHTIrchleqg----------vinrdefKIVYIAPMKALAAE 555  fruit fly
F1NTD6        485 RLNRIQSIVFETayntNENMLICAPTGAGKTNIAMLTVLHEIrqhvqhg----------vikkdefKIVYVAPMKALAAE 554  chicken
Q54G57        482 KLNRIQSRVFESayksNENILISAPTGAGKTNIALLTILHEIesninpyg---------yldkdnfKIIYIAPLKALASE 552  Dictyostelium...
NP_001271200  476 RLNRIQSIVFETayntNENMLICAPTGAGKTNIAMLTVLHEIrqhfqqg----------vikknefKIVYVAPMKALAAE 545  human
NP_011787     287 TLNQIQSLVYPVayktNENMLICAPTGAGKTDIALLTIINTIkqfsvvngen-----eidiqyddfKVIYVAPLKALAAE 361  Saccharomyces...
AED97425      507 SLNRIQSRIFQTvyhtNENILVCAPTGAGKTNIAMISVLHEIkqhfrdg----------ylhknefKIVYVAPMKALAAE 576  thale cress
CAA21686      311 KLNVIQSIVFEQayktKENLLICAPTGAGKTNIAMLTILNTIhehqnsrg---------dimkddfKIIYIAPMKALATE 381  nematode
O60072        277 TLNRIQSLVYPIayktNENMLICAPTGAGKTDVALLAMLQTIsnyvesmnlmde-sepldvhrddfKIVYIAPMKALAAE 355  Schizosacchar...
CAK75634      458 RLNVIQSQIYPKafltEENLLVCAPTGAGKTNIALLAILQELskrvdqke--------krlkdqdfKIVYISPMKALASE 529  Paramecium te...
EEA19860      277 SLNRMQSLLYDVayktSENMLICAPTGAGKTDAAMLTILNAIaknvtpnpleepdatefvvqlddfKIVYVAPMKALAAE 356  Penicillium m...
Feature 1                                                                                         
NP_650472     556 MVDNFSKRLkslqIAVRELTGDiqltkaemaatQILVTTPEKWDVVTRkgsgdvalislVELLIIDEVHLLHgeRGPVVE 635  fruit fly
F1NTD6        555 MTNYFSKRLeplgITVKELTGDmqlskgeilrtQMLVTTPEKWDVVTRksvgdvalsqlVKLLILDEVHLLHedRGPVLE 634  chicken
Q54G57        553 MVEKFSNSLkylgIVSKELTGDmqltqkelketQIIVTTPEKWDVITRkssdv-altklVRLIIIDEIHLLHeeRGPVLE 631  Dictyostelium...
NP_001271200  546 MTDYFSRRLeplgIIVKELTGDmqlskseilrtQMLVTTPEKWDVVTRksvgdvalsqiVRLLILDEVHLLHedRGPVLE 625  human
NP_011787     362 IVDKFSKKLapfnIQVRELTGDmqltkaeilatQVIVTTPEKWDVVTRkangdndlvskVKLLIIDEVHLLHedRGSVIE 441  Saccharomyces...
AED97425      577 VTSAFSRRLaplnMVVKELTGDmqltkteleetQMIVTTPEKWDVITRkssdm-smsmlVKLLIIDEVHLLNddRGAVIE 655  thale cress
CAA21686      382 MTESFGKRLaplgLKVKELTGDtqlsrnevadtQMLVLTPEKWDVITRkstsdnslinvVRLLIIDEVHLLHdeRGPVIE 461  nematode
O60072        356 VVEKMGKRLawlgLKTRELTGDmqltkteiaetQILVTTPEKWDVVTRksvgdtqlaekVRLVIIDEVHMLHdeRGAVIE 435  Schizosacchar...
CAK75634      530 IVEKFQTKLrylgVKVKEFTGDmqlskkelqetHIILTTPEKWDVITRktnq---iseqLKLLIIDEVHLLNddRGPILE 606  Paramecium te...
EEA19860      357 VTEKLGKRLawlgIKVRELTGDmqltkreivetQIIVTTPEKWDVVTRkstgdtelvqkVRLLIIDEVHMLHdeRGAVIE 436  Penicillium m...
Feature 1                                                         
NP_650472     636 ALVARTLRlvessqsmIRIVGLSATlpNYIDVAHFLrvnpmkGLFYFD 683  fruit fly
F1NTD6        635 SIVARTLRqvestqsmIRILGLSATlpNYLDVATFLhvnpyiGLFYFD 682  chicken
Q54G57        632 CIVARTLRqvettqemIRIVGLSATlpNYKDVARFIrap-asGTHFFD 678  Dictyostelium discoideum
NP_001271200  626 SIVARTLRqvestqsmIRILGLSATlpNYLDVATFLhvnpyiGLFFFD 673  human
NP_011787     442 TLVARTLRqvessqsmIRIIGLSATlpNFMDVADFLgvnrqiGMFYFD 489  Saccharomyces cerevisiae S288c
AED97425      656 ALVARTLRqvestqtmIRIVGLSATlpSYLQVAQFLrvntdtGLFYFD 703  thale cress
CAA21686      462 TLVARTLRqvemsqsgIRIVGLSATlpNFIDVARFLrvnpykGLFFFD 509  nematode
O60072        436 SLVARTQRlvetsqqmIRIVGLSATlpNYLDVADFLgvnrykGLFYFS 483  Schizosaccharomyces pombe 972h-
CAK75634      607 CVVARTLQqvqraqsyIRLVGLSATlpNYWDVAIFLech-kdSVFFFD 653  Paramecium tetraurelia
EEA19860      437 SLVARTERqvestqslIRIVGLSATlpNYIDVADFLkvnrmaGLFFFD 484  Penicillium marneffei ATCC 18224

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