2DAF


Conserved Protein Domain Family
Ubl_IQUB
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cd17061: Ubl_IQUB 
ubiquitin-like (Ubl) domain found in IQ and ubiquitin-like domain-containing protein (IQUB) and similar proteins
IQUB is an IQ motif and ubiquitin domain-containing protein that may play roles in cilia formation and/or maintenance. It contains a conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions.
Links
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Statistics
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PSSM-Id: 340581
Aligned: 16 rows
Threshold Bit Score: 111.973
Created: 27-Oct-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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key conserved
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: key conserved lysine K27, 1 residue position
Conserved feature residue pattern:[KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:K27/R (Ub numbering) is a lysine conserved in the Ubl_ubiquitin_like family; it is one of 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering), the other 6 lysines are not conserved in this family; may have other functions, for example in NEDD8 K27 is involved in the mechanism of protein neddylation
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                     #                                                 
2DAF_A        14 SLATVKVVLIPvGQEIVIPFKVdtILKYLKDHFSHLLgiPHSVLQIRYSGKILKNNETLvqhGVKPQEIVQVEIFSTNP 92   human
KXJ23957     151 FDVQVKFVIMPeGEVLTLTCSDkqGISELRDHLSAELgqPPNVILMLHDDKLLEDKGSLsdiGLQPGQTLQIELQSSDP 229  Exaiptasia pallida
XP_007063255 228 ATATVKILLVPeIQMITMAFNIdqTVRKLKQCFASQLkvPPDVLQVVFQGRLIEDSETLmdiGVRPHGTIQIEMFSLDP 306  green sea turtle
XP_002666923  89 STATVKILLMPeRHMITVAFTIglTILDLKKHFSFEMrvPYDIIQITLDEKNVNDDQTLmdiGVQPHGMIQFEMSSLDP 167  zebrafish
XP_018108068 202 ATATVKIILAPdGDVVTLAFSIsfSIRDLKNYFASQLkiPETIIQIMFEGHVVNDQETLvdlGVTPHGTIQLDMISLDP 280  African clawed ...
XP_006004891 307 ATATVKIMLMPgNHVMTLAFEIgrTAGYLKYHLASELkiPPDVIQLMFSGKLLKNSVILmdlGVIPNGTVQIEMSSTDP 385  coelacanth
KKF22164      92 STATVKVVLVPeGHVMTVAFAIglSIQELKCHLASELrvPADVLQISLDGRVVEEQKSLmelGVRPHGSTRMEMSSTDP 170  large yellow cr...
XP_007896759 149 VTATVKVVLLPdEHVMTLAFPIcsTTGKLKERFGKELkiPPRMLKLTYNSKTVNDSQTLvdlGVRPHGAFQLELSSISP 227  elephant shark
ETE67865     184 AIVTVKFMLHPdIQIFTKFFNInqNVEQIKQYFAKRLkiPLNLLQIGLLGRKIENYETLwnlGVQPNGTIQFDMYSLDG 262  king cobra
NP_001154963 104 PTVTVKFQLVPsKEVITVATPLnvTIQQLSMQLSSDVkvPASLLHFSYEGKSVDPETTLkdlGVAPTGTIQLDVTSSDP 182  vase tunicate

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