Conserved Protein Domain Family
Lig

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COG0272: Lig 
NAD-dependent DNA ligase [Replication, recombination and repair]
Statistics
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PSSM-Id: 440042
Aligned: 720 rows
Threshold Bit Score: 628.593
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_273708      1 MnpnskhntnftnllkpsdsdikQFAAQHICRLTDLLNRYAYEYYTLDAPSVPDAEYDKLFRELEALELNhPELKLPDSP 80 
WP_111525223   1 M-----------------------DKKKRIKELVEILNKAAKSYYVDAVEIMPNIEYDKLYDELLELEKE-TNVVLSNSP 56 
WP_012743053   1 Me--------------------nNKIKDKIDELVESLNRASKAYYNGADEIMPNYEWDAMFDELTQLEKE-TGYIRHDSP 59 
WP_015358256   1 M----------------------DEKVVRIKELVNRLNEASKAYYQENREIMSNYEYDKLYDELVELEKE-TGIVLSNSP 57 
NP_347827      1 M--------------------------KLIEDLIEKLNKYSYSYYVLDNPIVADKEYDIMYDELKRLEEE-TEYINPNSP 53 
WP_066049001   1 -------------------------MVNRIKELISLLNKAAEAYYQKDTEIMSNQEYDRLYDELEHLEKE-SGIILANSP 54 
WP_106790578   1 -----------------------------MKELVDLLNRAGKAYYQDAQEIMSNYEYDSLYDELVSLEKE-LGMTLSNSP 50 
WP_106056170   1 Mn--------------------lDDKKRRIEELIETLNKASAAYYDEASEIMSNYEYDALYDELESLEKK-TGYTPLNSP 59 
WP_012200935   1 M----------------------QGKKQRITQLTELLDEAARVYEQEDREIMSNFEYDKLYDELKKLEEE-TGIVLAGSP 57 
WP_087459099   1 -----------------------------MRELIELITEYDYHYYTLDKPKVTDADWDRLYDELVRLEAE-TGITLPNSP 50 
NP_273708     81 TQRVGGEPL-AGFAEVRHEVPMLSLTNAFSPqdengvfdhAEMYAFDQRVRDGLd---------G--GNPEYVIEPKFDG 148
WP_111525223  57 TQNVGYEIA-GELPKKAHESPMLSLDKTKSV---------EDLREWLGENKA--------------------LLSWKMDG 106
WP_012743053  60 TQNAGYEAE-AG-NREPHEYPALSLAKTKSI---------EELKKWAGDM--------------------PIWLSWKLDG 108
WP_015358256  58 TVKVGYELL-SSLPKEAHEQPMLSLDKTKDV---------NALVEWLGDKKG--------------------ILSWKLDG 107
NP_347827     54 TQRVGDIIL-DKFEKTHHKNKLWSLDKAQKK---------DEVKAFVNKCVKFVeqyn--lthsEklPSPQFVVTQKLDG 121
WP_066049001  55 TQRVGYTVL-SNLQKVKHDSPILSLDKTKEP---------QKLKSFLGGEKG--------------------ILSWKLDG 104
WP_106790578  51 TVNVGYQVL-SELPKERHEEPMLSLDKTKEV---------EGLKEFLGDQNA--------------------LLSWKMDG 100
WP_106056170  60 TKNVGYTVQ-SELPKERHRSRMLSLDKTKSR---------EELAAWLGDHEG--------------------LLSWKLDG 109
WP_012200935  58 TRKVGYEIL-SELPKERHESAMLSLDKTKEV---------PALIDWLGNKEG--------------------ILSWKMDG 107
WP_087459099  51 THRVGSGILvDTFPEHKHLARLWSLDKAQSA---------DELREWDKRVRKLIldhntknpdgQplPEPQYVLEQKFDG 121
NP_273708    149 LAISLLYRDGVLVQAATRGDGTTGEDVTQNIKTVSNIPLRLHGEntpELIEVRGEVLMLKADFVALNKRQAENGQKPFAN 228
WP_111525223 107 LTIVLTYRDGELAEAVTRGNGTIGEVITNNAKNFQNIPLKIEFK---GELILRGEAIIKYSDFKRINDAIEDATAK-YKN 182
WP_012743053 109 LTLVLTYDGGRLVKILTRGNGTVGSNITFLQDAISGFPKEIPYK---GHMVVRGEATISYTDFKLLNDTIEDDDEK-YAN 184
WP_015358256 108 LTIVLTYSNGELIKAVTRGNGEVGEVVTNNAKVFRNLPIRISYK---GNLVLRGEAVIRYSDFEKINREIENVDAK-YKN 183
NP_347827    122 LTINCSYNESRLIKSATRGTGEIGEDITEQSKTILNLPNAINYS---GEIDVHGEALMTKNALEQYNSNL-KVNETPLKN 197
WP_066049001 105 LTIVLTYENGTLQQAITRGNGEIGEDVTHNARVFANLPLQISFK---GSLVLRGEGVISYTEFHRINEGAQE-EEK-YKN 179
WP_106790578 101 LTIVLTYQGGELRKAVTRGNGEVGEVITNNARVFRNIPLKIGYE---GELILRGEAVIGYRDFERINEEITDVQAK-YKN 176
WP_106056170 110 LTVVLTYEGGELVKAVTRGNGDIGEVITPNARVFVNVPKHIPYK---GHAVIRGEAVITYEEFDRINEAIDDADAK-YKN 185
WP_012200935 108 LTIVLTYRNGELVKAVTRGNGEVGEVVTNNAKVFKNLPLTIPYE---GELIIRGEAVIRYSDFEMINAQIPDADAK-YKN 183
WP_087459099 122 LTINLTYENGVLVQAATRGRGVVGESILPQVKTIKSVPLSIPFRd--GLIEVQGEAIMPLSVLAKYNEQATETGAELLKN 199
NP_273708    229 PRNAAAGSLRQLDSRITAQRKLHFFPYSVARQQDgFV-AEEHIQELAYFQALGFSLpNGNFGCFKNIDEVLAFYEHM-QQ 306
WP_111525223 183 PRNLCSGSVRQLNPAITKSRMVYCNIFNVVKADG-IDfENSKAKQFEWAKNEGFDV-VEYKFT--DSKSIADDIAEF-ES 257
WP_012743053 185 PRNLASGTLNLDDVEEVKRRHVVFYAFTLVHIDD--D-IISWGDRMSYLSDMKFNV-VKRE--ATDAAGLDEAVKRW-TR 257
WP_015358256 184 PRNLCSGSVRQLNNRITAERNVYFFAFQIVKVDE-PEiGKFRSRQLNWLKSQGFDV-VEFKEV--DSSNLEQTVKWF-SE 258
NP_347827    198 LRNGAAGALRNLNIKETARRKLVAQFYDLSYTD--KK-LKKYSEILLFLKSQGFNI-TEY-NICNNFDEINQAIDNI-GE 271
WP_066049001 180 PRNLCSGTVRQLNSEIAAKRRVQFFAFTLVSAEG-RLlSDSKAENLKWLAGLGFDV-VDHKIV--TAETVEQEVEWF-RA 254
WP_106790578 177 PRNLCSGSVRQLNNEITARRNVRFFAFALVRASG-VDfHNSRAAQMEWLKEQGFEI-VEYHMV--TRDTVEREVIKF-SE 251
WP_106056170 186 PRNLCSGSVRQLNSKITAERNVRFYAFTLSEADG-VDyEGLRSNQMKWMAEQGFDV-VEYVKV--DNKSIFEAIDNY-AE 260
WP_012200935 184 PRNLCSGSVRQLNNAITAKRNVNFFAFALIRMDE-MNrFKTMMEQFNWLKELGFDV-VEEKLV--TAENMAETMEYF-ES 258
WP_087459099 200 ARNAASGALRQKNVESTAKRNLDAYLYGIGYFEG-ID-FDTHEQILDFLRENRIKT-SSYSKVYADIEAVIEEIARFdQE 276
NP_273708    307 KRP--ELPYEIDGMVVKVNSLAQQHELGFISRAP-RWAVAHKFPAEEALTIVEAIDVQIGRTGAVTPVARLQPVFVGGVT 383
WP_111525223 258 KIE--SNDIPSDGLVLLLDDIALGERLGSTSKFP-RNAMAFKWSDERQVTKLKYIEWSLSRTGLINPVAVFEPVELEGTT 334
WP_012743053 258 DVEsgRMDVPVDGLVICYDDTAYAAGGSVTGHHAtRAGFAFKWQDEAVDTRLRYIEWSCA-VSTISPVAVFEPVQIEGTT 336
WP_015358256 259 QVV--KNDFPADGLVLAYDDVEYGRSLGTTAKFP-RDSIAFKWQDEVAETRLIKIEWSASRTGLINPIAIFEPVELEGTT 335
NP_347827    272 VRS--SLQYDIDGVVIRLNDIETSRLMGYTIKCP-KYAIAYKFKAKETTTKLIDVEWNVGRSGRINPTAILEPVELAGVI 348
WP_066049001 255 YVK--KNDIASDGLVLTFDSIDYSENLGSTAKFP-KDSIAFKWADEMAETTLREIEWNTSRTGLMNPIAIFDPVELEGSR 331
WP_106790578 252 KIP--ENDFPSDGLVLIYDDIEYGQSLGRTAKFP-RDSIAFKWADETSRTRLLEIEWSPSRTGLINPVAIFEPVELEGTT 328
WP_106056170 261 RVH--SFEIPSDGLVLTLEDLEYAATLGTTAKFP-RDSLAFKWADQQAETILREIEWSPSRTGLLNPIAIFDPVELEGTT 337
WP_012200935 259 HII--TNDFPSDGLVLFFNDIAYGESLGRTSKFP-RNGIAFKWRDEIKETTLQEIEWSASRTGLINPVAIFEPVELEGTT 335
WP_087459099 277 DHP--HLDYLIDGMVIKINDLATRVALGFTDKFP-RWAVAFKFEAEEYSTILQSVVWDVGRTGKITPTALLEPVDIGGVT 353
NP_273708    384 VTNATLHNQDEVSRKDVRVGDTVVVRRAGDVIPEVVRVIFERRpMREtavavsdgighrqddlfaetpsanqtqsvplhK 463
WP_111525223 335 VSRASLHNVSIFEDLMLGVGDEISVYKANMIIPQVYENLTK-----S--------------------------------N 377
WP_012743053 337 VSRASLCNLTEIERLGVGKECTLSVIKANKIIPKCIAVKDA-----V--------------------------------G 379
WP_015358256 336 VKRASVHNISVMESLELGIGDTIGVYKANMIIPQIAYNLTK-----S--------------------------------G 378
NP_347827    349 VKRATLNNMDDIKRKKIKKGARVFLRRSNDVIPEIMGVTEETE-GET--------------------------------K 395
WP_066049001 332 VSRASVHNVSILRELKLGIGDSIKVYKANMIIPQIAENLTC-----S--------------------------------D 374
WP_106790578 329 VSRASVHNISIMEELELGVGDEIEVYKANMIIPQIARNLTR-----S--------------------------------G 371
WP_106056170 338 VKRASVHNLNIMETLKLGIGDTITVYKANMIIPQIGDNLTK-----S--------------------------------G 380
WP_012200935 336 VSRASLHNISIMEGLELGLGDKVTVYKANMIIPQIADNLTR-----S--------------------------------G 378
WP_087459099 354 VQRATLNNWGDIQRKGVQVGSRIAIRRSNDVIPEVLFALEDDE-LQT--------------------------------T 400
NP_273708    464 PYRLPTHCPICRSEIE----REEGEAVARCSGGMLCQAQRAQGLIHFASRKAMDIDGLGEKQIEQLVAQDLVRHFADLY- 538
WP_111525223 378 TEKVPDTCPACGSHASi--kQDNESKVLLCTNP-DCQIKHIKQYALMASRDALNIDGLSESTLEKFLSKGFIKNDSDIF- 453
WP_012743053 380 EVEIPKECPVCHHPTRifvsKNSGVKTLHCTNP-DCTAKNVKKFSRFVSKSGMDIDGLSVQTMLKFINEGFIKQFPDIY- 457
WP_015358256 379 NIEIPEHCPVCGGQTQi--rQENGVKFLYCTNG-ECPAKHIKSLVHFVSRDAMGIDGLSEATIEKFVEKGFIKDYADIF- 454
NP_347827    396 EIEAPTICPYCGSEIV----KE--GVHLFCENTLSCKPQMVKSIVHFASRKAMNIEGFSEKTAEQLFEKLNIKSISDLY- 468
WP_066049001 375 SAEIPKECFVCGGETQi--kKQRDGEALYCTNP-ECSAQRIQRLTHFVSRDAMNMEGFSEETIKKFLEMGFIQQYPDIF- 450
WP_106790578 372 VRDIPAVCPVCGGKTQi--rQEGNAKTLYCTNP-ECQAKHVKAFTLFVSRDAMNIEGLSESTLEKFIARGFIREYADIF- 447
WP_106056170 381 NIELPSHCPVCDGTTEi--kLMTGTKVLTCTNP-NCLAKQVKRFSLFVSRDALNIEGLSEQTLLKFIGLGYIKSFADIF- 456
WP_012200935 379 HLPIPKTCPVCGGDTMi--kQDSDVKSLYCMNP-ECLAKKIKSFTHFVSRDAMNIEGLSEATIEKLIAKGLIKELADIF- 454
WP_087459099 401 PIDKPEHCPSCGSELV----EK--GAHLFCQNTDGCRTQVVNRISHFASRGGMDIETFSIKTAEQLFDELGVSDPADLYd 474
NP_273708    539 RLD--IPTLQKMKETADKTvaesdqmpsegssvgasgkhkkqpvkwAENILAGIEASKTPELARFLFALGIRHVGERTAK 616
WP_111525223 454 KLDryKDEIVNMEGFGRRS---------------------------YEKLMAALEEAKHTNVARFLYSLGINGIGSANAK 506
WP_012743053 458 HLPehFDKISSMEGFGEKS---------------------------CMNMQTAIEKSRHVHPVNLIFALCIPLIGTDAGK 510
WP_015358256 455 RLErfRNEIVKMEGFGEKS---------------------------YSNLISSINKARKTNAVRLLYSMGIPGIGLSNAK 507
NP_347827    469 RIT--KEELMSLDKFKDKK---------------------------ASNLINAIEKSKECDLDSFVYSLGIPNVGKKTAT 519
WP_066049001 451 CLEkyEGQIKKMEGFGEKS---------------------------YSNLIKSIEKAKQVELPNFIYALGIDQVGLRNAK 503
WP_106790578 448 HLDrhRDEIQSMEGFGEKS---------------------------FQNLEASIEKARTTTLPRVIYGLGIANIGLANAR 500
WP_106056170 457 RLEnhRDEIVELDGFGKKS---------------------------YDKLSSSIEKSRHTVPARILVALGIPGVGVTTAA 509
WP_012200935 455 HVKdfKEEITTMEGFGEKS---------------------------FRNLVDSVEKARTPILAKFIYSLGIANVGLANAK 507
WP_087459099 475 SLS--MDKLLSLPRFGEKK---------------------------AQNLLAAIEKSKSKDLTSFLNALGIPNTGARMAR 525
NP_273708    617 TLAQAFG-TLERVRRA--PEPVLACLPDIGTVVARSIAHFFAQAEQQAMIDELLAAGVAPQ-TQAvtipparhaepqrwi 692
WP_111525223 507 MIAKYFDnDIDKIITA--GKDDLLEIEGIGEVLANSIVDFFKDSKNIENVKSLREV-LIFE-VEEs-------------- 568
WP_012743053 511 KIVNAIG--FDGFADRmrNATDFVDIDGIGQEKSGSILEWYANPQNSTMFEALIKE-LDIE-KVDi-------------- 572
WP_015358256 508 RIAGYFNhEWGRIENA--TFEELINIDGIGDIMARDFVAFFKNERNRERIRELMAE-IELE-KETa-------------- 569
NP_347827    520 DLCKQFK-SFENIKKA--SYFELILVQDIGSIVAKSIVDFFKQEKIEKSLNELFKLGVKPS-YEEs-------------- 581
WP_066049001 504 LLCSKYHyDLDKIIHA--SEDELIGIDGFGTVIAHSIHHYFGEEEHKTLLNCALKY-LKIKvPVEi-------------- 566
WP_106790578 501 MICRAFDyELDRMLAA--DQEDLNEISGIGDVIAGAFVAYFKDPVHRRQLEDLLKE-LTIV-EEEg-------------- 562
WP_106056170 510 QIARAYEnKWAKISSL--TYDELISVSGIGEVMARDYEAFFADEHNKSVVLDLVSE-LDID-ESYe-------------- 571
WP_012200935 508 LICKEFGyDFNKVSNA--TVDELTQIPQIGYVIAEAFVSYFQKPENKLIIEDLLKE-ITFE-KEEa-------------- 569
WP_087459099 526 DLAETFG-TLERVQSA--AFEELVAIPGFGDIVAESITTFFGQERIQQSIQRMLDAGVTPT-HEAp-------------- 587
NP_273708    693 arlpgfkisenkaqalwelagknieglqtdkalptdwqawrsepqnaallenlktffaqmpsedeAAqgsdGINKAVAGK 772
WP_111525223 569 -----------------------------------------------------------------------AGSDSFAGK 577
WP_012743053 573 -----------------------------------------------------------------Kd----MSEGSLNGK 583
WP_015358256 570 ----------------------------------------------------------------------sDKSQIFRDI 579
NP_347827    582 -----------------------------------------------------------------E-----VSESVFNDK 591
WP_066049001 567 ----------------------------------------------------------------------kTEGSLVQGL 576
WP_106790578 563 ----------------------------------------------------------------------aGAPQTLAGL 572
WP_106056170 572 -----------------------------------------------------------------------KAGEALSGE 580
WP_012200935 570 ----------------------------------------------------------------------aGGSEKLKGL 579
WP_087459099 588 -----------------------------------------------------------------QIve-aAAESPFFGK 601
NP_273708    773 TFVLTGTLPTL-KRDQAQSLIEAAGGKVSGSVSKKTDYVVAGE--AAGSKLEKANALGVSVLSEAELLTLLG 841
WP_111525223 578 VFVITGSLEHFtNRNELKELIEKNGGKVSGSVSSKTNFLINNDttSNSSKNKKAKELGVEIISEEDFLKLLE 649
WP_012743053 584 TFVITGDVHDFaNRSEFKAYVESQGGKVTGSVSKKTDYLVNNDteSTSSKNKKAKELGIPIISEDTFIEMFG 655
WP_015358256 580 TFVITGSVNHFkNRAELKKVIEERGGRVTESVTSNTNYLINNDinSTSAKNKKAKELGIPIITEEQFLEWLN 651
NP_347827    592 TVVATGSLQNY-SRTEIKEKLESLGAKVAGSVSKKTDYVIAGE--NAGSKYDKAVALGVKILTEEKFEELIE 660
WP_066049001 577 TFVVTGDLERFsNRKALSEAIELLGGKVTGSVTKKTNYLINNDvfSASSKNEKAKQLGIPIISENDFILQFK 648
WP_106790578 573 TFVITGSVTHFaNRSEVKALIESMGGKVTGSVTSKTDYLINNDveSTSSKNKKARELGIPILSEEEFLEMTQ 644
WP_106056170 581 IFVITGSLEHYkSRTELKKEIEAQGGKVAGSVSKNTSYLVTNNpeSGSSKNKAAAELGVKIITEDEIRTMLG 652
WP_012200935 580 TFVITGSVEHFtNRNEVKDVIEQHGGKVTGSVTAKTNYLINNDntSSSSKNKKARELGIPVITEEEFIQLLN 651
WP_087459099 602 TVVLTGTLTTM-GRNDAKAKLEAFGAKVTGSVSKKTDFVVAGE--EAGSKLTKAQDLGVTVLTEQEFIALIG 670
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