Conserved Protein Domain Family
Choline_transpo

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pfam04515: Choline_transpo 
Plasma-membrane choline transporter
This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals.
Statistics
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PSSM-Id: 461337
Aligned: 265 rows
Threshold Bit Score: 88.4072
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002952038  366 IGASIVAGFVLLITLLCISRIRIAVACVKVASQAVGSMP-SIIFFPILPFVLEVGLVIYWIAVT--A-----L-MYSSGD 436 
ESS30738      693 CLCCLAALLVAFFALFFRRELHVSTSVLTASATLLQQAPsKFLL--LVPLAAATALASQGALVVaaV-----ShLAALGP 765 
CBN80036      282 YLAYGCAFLFLCLIVFLRKQIALANGIIKESVRAIGTVK-MMFFMPLLQCAAIVAFLVPWVVYS--V-----Y-TASMAD 352 
XP_002290523  259 YVLYGLAVLWVMIICYIRRRIVLAIYCVKESARAISAMP-VMTLFPVAQVLGLVAFTVVWGIYM--A-----F-LASSGD 329 
EEC48192      310 IVLYVIGGIMILLACCLRSQIQTAIGCVKQAGKAVNCMI-IILLVPVLQAVGFLAFLIVFGYYG--A-----N-LASLGK 380 
Q38CI7        301 IGLWIGALVYVFVIIGACPRIRLVCALAKIASRVVDNAP-STVLLPILMNVAILCLLVWSILVAlgL-----YnARRKTG 374  Trypanosoma b...
XP_001581044  286 VVIWCIAFIIILIIIFLWSKLKSAVAIIKVAAMALGYNF-LVIFVPIITMIFCFLFWAALLVSSvtLytsasF----KYE 360 
EAX96980      106 VIALVIAALIIWFLIRIWSKVNLALSHIEFACKVFYNNLaKFIFIRIIWLFIFILIGSIVLVSSaaLysiyeF----KYN 181 
XP_001309909  256 VIVWVIAALIIWFLVRIWRKLNLAISLINIAADAFYYNF-TTIIFRILSTFIFILVSSIVLVSSvaLysiyeF----KYN 330 
EEY62350      293 VVMCCAAVLFFLFALVNMSRLLLAGAFISHAARALSQLK-RLLVLPFISYVLLMLLFGWGILVT--------VcIFGAGE 363 
XP_002952038  437 LTAHCrtqsskesfsfskytnvsnlmdattfnpsselsssfnyssyslspnatmgncytnvttdqraFLCGRDPNCYLSY 516 
ESS30738      766 IPTLPisac------------------------------------------------------ipslSPWVRLPL----- 786 
CBN80036      353 ITT------------------------------------------------------------------EEVAGLTVKSF 366 
XP_002290523  330 VT-------------------------------------------------------------------GSYGCFLYKEL 342 
EEC48192      381 ISVVEvp-----------------------------------------------------------lDGTGTQEIAFRKY 401 
Q38CI7        375 KISFVpvtdaigindgs---------------------------------------fkgigetkfyqGVVEGVEH----- 410  Trypanosoma b...
XP_001581044  361 IDN-----------------------------------------------------------------DGNDKGIGQVKF 375 
EAX96980      182 IPD-----------------------------------------------------------------DGFFKGIGRITF 196 
XP_001309909  331 IPD-----------------------------------------------------------------DGFFKGIGRITF 345 
EEY62350      364 TSSRIatis-------------------------------------------------------atsPSTIRVVT--ESF 386 
XP_002952038  517 DWNNRLKYAFIYHFF----GLLWTNQVIIGFACVTIAGAIAQYYWSr---gDS-An---MSAFPVLVALKNTIIYHMGSI 585 
ESS30738      787 -LSSSSVALLLALLF----VALWTGAFLNAISRMIVSYFASAWYFMprhmhgrr----eclkakaaEAVKVVFSYHLGSA 857 
CBN80036      367 EYSDEVEKRGWYLLF----VFFWTTQFVVAMGQIVVALTVVKYYFTrdvetVNn------G--TFWKSLKEGLRFHTGTA 434 
XP_002290523  343 TYSTNTKYAALYMLF----MWFWTSQFLVAVGQLVVAVSVSLWYFSrdrsqIGn------T--TFCRVLYLVSFHHLGTA 410 
EEC48192      402 EFDDFVENCGWYLLF----CLFWTSNFIVAVGDMIVAISVSKWYFTknkvtIGs------W--TVLTSIWQTLFYHAGTC 469 
Q38CI7        411 ------RYALVYLLFgelfAFLWCVSFLNAVSFTSISFVSTFWYFS-----NLnGgkkrVPFFGVLRAFVWTVFYHAGTL 479  Trypanosoma b...
XP_001581044  376 DLNKVLQYMLIYNFV----YLIFISVHMYFVNYYASSVSIVKWYFSgqggktc-------cgcscfFGFWLAWTKALGTI 444 
EAX96980      197 DW-NIVFFMLIYNIV----FLVFIHYLLIHLCHYVTSAAIVKWYFTerkgnsh-------fgrisfHGIWFAWKKGLGTV 264 
XP_001309909  346 DW-NIVTCMLIYNFV----FLVFIYILLNQVSYYATSAVIVKWYFTkqigntr-------nghisfHGIWLAWKKGLGTI 413 
EEY62350      387 EVSTKLRWLFLYHLW----GMYWSVNFVLAIGEMVTATAMSLWYFApe--nRItGlkefDEPDPVSYSAHTTLKYHLGTL 460 
XP_002952038  586 CFAACI--------IAIIQLIRFLLEYlDRKTKEiqqQNKFAE----------------WAMCCVKC----CMWCLEQI- 636 
ESS30738      858 ALGGLI--------LSSVQMLKLLFGW--------------ARyravrrnhsvfkrilcRVSNCVAC--------LYTP- 906 
CBN80036      435 AFGSLI--------IAIIKTIRAMLTYmQKKLQKs--GSKAAQ----------------AVLCCLSC----FFWCLEKC- 483 
XP_002290523  411 AFGSLV--------IAIVKTIGTILTYvQKRLSKs--QLRLAV----------------LLLKVLHN----LMWCIEKC- 459 
EEC48192      470 AYGSLI--------LAVVQMIRAMIARaQKAAKDa--NSKIAG----------------AILCCCQC----FFCCLECC- 518 
Q38CI7        480 ALGSLL--------IAILQIVRILLVYaAEKAEEa----VDRH----------------DLIQCLHCylqyALLCFENF- 530  Trypanosoma b...
XP_001581044  445 TISSLI--------MTPLYLFIIFMEYldrkskme-----------------napifiqFLIKCLKC----CLWCFTKI- 494 
EAX96980      265 TISCLIr-------TTLMILVRQLANY------------------------------------------------LNKLp 289 
XP_001309909  414 TISSLIltalhryvMQVVKLFRNISLI------------------------------------------------VGLL- 444 
EEY62350      461 ALSSGS--------VAPVEHIRSFFLYlENKNEFd--ANAVTE----------------FATKCCCC----CIWCFKNC- 509 
XP_002952038  637 ----------VKFINRN----------AYIMMAIKGKGYCCSAIQAVKLIVSNAL-RIAVVNLVGDWLI----FLGKVSV 691 
ESS30738      907 ----------VKFVTPT----------AFIFVALLGQPFLQASWTAIATLTRNPAaTAFVWQ-IGWLLQ----LVGQLSI 961 
CBN80036      484 ----------VKFINKN----------AYIQVAIFSTSFCRSSKNAFWLIARNLG-RVGAVTVVTDFVV----FIMKLVI 538 
XP_002290523  460 ----------LKFINKQ----------AYCQTAIFSYSFCKAARMGFFLILRNAL-RISAVSIVSRIVL----FINKTFI 514 
EEC48192      519 ----------LKFLNKN----------AYIQTAIFSTAFCKSCRQAFYLIFRNAA-RIAAISYVSGAVL----IVGKLFI 573 
Q38CI7        531 ----------VSSINKN----------IYVVVCLTSGSFCTSACTGLSVLKGHSS-DLFLISWMVLCVK----ILGKLFV 585  Trypanosoma b...
XP_001581044  495 ----------VQYLNKV----------LFTIQQIFNTNFGPSAKLVVDVVISDALlTVMLNG-ISFFIL----FLSKVVV 549 
EAX96980      290 ltgipfintfINMLFRLsnliafvlasTYTTQHIFNTPWIPSAKLEIGFIAIDKLfTIIFM--VIVVIIdwvaLIGNFSM 367 
XP_001309909  445 ----------LRFINWLlqc-----scLLPIQHIFNTGWIQSAKLEHDFLVYDFLfSIIMRV-TSNFIF----WLSSLAI 504 
EEY62350      510 ----------LKYICKE----------ALYVTAIQGTNFYTSGKLAYTLISSNLI-RVGALSRIGHASV----LLGKLIV 564 
XP_002952038  692 AAAC-GVI-A-------YAMTEa--KYYnspeefpntylYSPVLVIAISVITAYAVAEIFFAVFEMAIDTVILAFCEDCD 760 
ESS30738      962 SICV-AWC-T-------Y-------TLLpmfpn-tysqlSSLWAPVFVAFVLSLYVASICMHVFGLAADTLLQAFLADRE 1024
CBN80036      539 GLGT-AGA-T-------YVFLQnfmKDDl----------YSPMGPVFFAGVMAYYVASSFAALLGMTTLTILQCFIADEE 599 
XP_002290523  515 TVAS-TVA-G-------YYYLEmhfGDEl----------NLLMMPTLLIGLVAYAVSEMFDEVFGMSISTLLQCFIADEE 575 
EEC48192      574 SAVT-TSV-S-------YYFIAediENEl----------HSVGGPVAIVFLISYWVSDFFMDVFDMAISTILHCVIADEE 634 
Q38CI7        586 TVGT-VVT-S-------YLLFKhttLAPg---------vDSMVMPLILIGIGAYFLSGPFFDVFDSSTLALLICYCYDHH 647  Trypanosoma b...
XP_001581044  550 -----SVItTllfmiwaY-------YGKns-------siAGSLLAAFVVFFLSYIVSSFLLSAYDNIIDIVFVCYQSEKS 610 
EAX96980      368 YVILfVLIdQimgegfnL------------------------FNPSLVLAAL---YGIIFLHVFRSIIDIIYVCQQSEKS 420 
XP_001309909  505 -----SLIsGflmryfeY-------KILgv--------qNPQIERLYLYSILNYFVLSCLTSTFYNIIHCVYACYEYEKS 564 
EEY62350      565 CTTT-GLI-G-------WFLLEdtpS---------------PVLPLVVIMLFSYSVAHAFMTIYETSINMLLMCFTLDEN 620 
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