Conserved Protein Domain Family
DUF4518

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pfam15008: DUF4518 
Domain of unknown function (DUF4518)
The precise function of this protein family is unknown but it is thought to be involved in apoptosis regulation.
Statistics
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PSSM-Id: 464440
Aligned: 30 rows
Threshold Bit Score: 289.91
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KYB26003       2 LNDTSRQGICEIL-ASLDDN---TLFNLAGTVT-QGLLKnrINTRDEAVNAILNYSPDALSFLRRKIITREVLFAYLHAK 76 
Q16YF0         4 SFDYERNGIADFF-TQTDPEvrkVTLTIGNIIS-KNTIK--EITLEKSLNVMLDNCRDAATLLSKNIVKPEFIYRYLQNY 79  yellow fever mo...
XP_001957750   3 VLDHHKAGLRDLLqTEKNTP---ILLQLSKSTT-KHVFK--TEDPSEALDVLVTQIGDTYKLLSKRSISKEILFTYLSTK 76 
XP_002034753   3 ISDSQKKGLRELLlNDNNLT---VLLQLAKCAT-KNVCK--TEDPEEALRLITTHIPDIYVLLSKRAITKELLFTYLSNR 76 
EDW32979       3 ISEVYKKGLRDFLlNEKNTI---VLMQLAKSTT-KNVCK--IKDPEEALDYLIAHVEDIHILLSKRLITRELLFMYVHRR 76 
XP_002046122   8 ISEQHRIGLRDLLiNETNTP---VLLQLARSVT-KNVCS--IEEPEEALDYLTAHTEDIHKLMYKRHITRDLLFKYLHKR 81 
XP_001983303   3 ISEQHIVGLRDLLvNETNIP---VLLQLTKSVT-KNVCK--VEEPEEALGYLTSHVDDIHKLLHKRHITRDLLFKYLHTR 76 
EFX74063       1 MLPGEISGIRDLL-SRLEND---VVYALADTAT-KRALA--FTSVNDAIDAIILHSESAFWFLNRKKLTRAILFEYLNAR 73 
BAH70644       2 DTDCEKRLLKQFL-DGLETN---ELCKIVRSIYhGGGIS--ANTRQDA--ELLLLSQPSVRVLSNKKVQITMLLKFLISK 73 
2_pfamImport   1 LTEFEKKCVSDLL-KTLELD---DLIELAKTCT-SGVIQ--TTNVDDSLDAILLHSKDLRSLLMRKKITKNVLFKYLHSN 73 
KYB26003      77 NVSIDLPATKNDLVQKTAQIWSI-------------------------------------QYVQEANNQA---------- 109
Q16YF0        80 NIQLPPESTKASLIKQCLNFWRVkygapagstpssdpqtivlpstsaessssnstmqnlvATGGPMGNQTngpgyd---- 155 yellow fever mo...
XP_001957750  77 DPGVTTDFTKADLITKVISYWDQcvvati--------------------------pqntnGTVSISENkk---------- 120
XP_002034753  77 RADAATDFSKADLIEKVIQYWKQehqssi--------------------------elsgdQTSSSLHNqs---------- 120
EDW32979      77 LPGIATNFTKADLVSKVIKYWEQq------------------------------------QTVEPINTpk---------- 110
XP_002046122  82 QPGTYTDFTKADLVMRVINYWDQqlnagt--------------------------mqvqsSAIVDTYCPTqpc------- 128
XP_001983303  77 LPCTSTDFTKADLVMRVIKYWDQqga-------------------------------sqnLAIVGTHNae---------- 115
EFX74063      74 RIPISGQAEKAALITRTLELWNSepqqiaa------------------------vvspttVSISHQEPRP---------- 119
BAH70644      74 GLIPTTDMTKADLCLAFKSLVESqpdyirppvq-----------------pmqmsvpnnmLAISQNNNIMhtqpyqaiqq 136
2_pfamImport  74 NISFPGNSEKTSLVEFVINIWNKa-----------------------------------yTAVDHQNSKEkkt------- 111
KYB26003     110 -----------------------DSGSISLLAEQFTRWFYAQLNKn--------------ECLNHEHFYPNVRLKIVMSN 152
Q16YF0       156 -----------------ttdpgqEQYPVNLLALDYTTWFYLKWNR---------------NSLDESAFWSDAMCSVMLEI 203 yellow fever mo...
XP_001957750 121 ----------------------eEDYPIHTIARKFGEWFFEIFNKdnlq---------------lvdLWSDATLNMTIIA 163
XP_002034753 121 ----------------------eEDYPIHKIARKFGEWFFERFNAdals---------------lvdLWVDATLHLTIRA 163
EDW32979     111 ---------------------neEEYPIHTMARKFGEWFFERFNSdcls---------------lvdLWDDAALHLTILA 154
XP_002046122 129 ---------------------reEEFPIHLIARKFGEWFFDKYNSdqlk---------------ltdLWSDAALQLEVIA 172
XP_001983303 116 ----------------------eQQFPIHLIARKFGEWFFNKYNNndlc---------------htdLWSDAALHLKVIA 158
EFX74063     120 --------------------------STPEMGLQFTKWFYELLFAvhkqs--------aigtKLSEQFWRDARLKITLNS 165
BAH70644     137 mpmqiptpntpaiepnrksrkdrDNELLEEFIEMFAKHFYDLLNDlgi---------pgkNQLDCRHFYENCTMSLKILG 207
2_pfamImport 112 --------------------qiaQDDSLERMAITFVEWIYNRINAivlqnlndqnnvnnlEILKEEDFWCDAKMCIKLTQ 171
KYB26003     153 NGQVSTEvIENDPLKVVQGLYALRTNFNLFFNPNLSSEGVQGRVDPHGlVLVLVCGTLH---T--GA--TCVGVFEQVFA 225
Q16YF0       204 SESQQGVeEVRGHRDIMNLILSLKFQYSFQLVPNIMFDGCQGRISDNG-VLVLTVGVVYndrRglDNrlTTLGEFESMIG 282 yellow fever mo...
XP_001957750 164 SDGVNEL-ECSTAAEVIEALSSAKQQFGFHFNPNLTHNGIQGRMDAYGhVVVLSCGTLH---T--QD--TCVGVFECAFG 235
XP_002034753 164 SDGINEW-ECTTAAEVLSALTSAKQQFDFYFNPNLTHAGIQGRMDSYGqFLVICCGTLH---S--RD--SCVGIFECAFG 235
EDW32979     155 SDGVSVH-ECETAPEVLSVLISTRNQFGFVFNPNLTHCGIQGRMDSYGqVLVLSCGTLH---T--TE--SCVGVFECVFA 226
XP_002046122 173 DDGTSEM-QCASAEQVLLALISAKQQFGFYFNPNLTHSGVQGRIDNFGqVVVLCCGTLH---T--AD--RSVGVFECVFG 244
XP_001983303 159 DDGASEL-ECVGVAEVLDALVKAKQTFDFYFNPNLSHSGVQGRMDPYGqVVVLCCGTLH---S--EQ--RSVGVFECSFG 230
EFX74063     166 SAATDCQ-EMIGSDEAANLLQMLLCQHGFLLNPNLSSNGVRERKDPHGmVIIGVCGTAH---Q--YD--NCSGIFEQVFG 237
BAH70644     208 GSNEIFE-TCEDSTSTLQCLLGIKKEHILFFSPHLGD--VKWKKESHGlVKVHIGGTLH------QGvgRMVGMFEQQFI 278
2_pfamImport 172 GSTVIADySSEGSKECLALIRYICKEYSVFFSPNLREEGTRGVSEPHGvVLVMNCGTLH---S--ANghHCVGLYEQIFG 246
KYB26003     226 LARDPQTDNNWKIKSSEINLKSE 248
Q16YF0       283 LRRDPLENNNWKITMYKLYIRYK 305 yellow fever mosquito
XP_001957750 236 LVRDPHLDNNWKPRHFKFLLKSA 258
XP_002034753 236 LLRDPLADNNWKPKKVKCLLKSE 258
EDW32979     227 LLRDPYSENNWKPKRLKCLLKSE 249
XP_002046122 245 LLRDPHANNNWKPKKFKCLLRSE 267
XP_001983303 231 LLRDPHACNNWKPKKFKCLLRSA 253
EFX74063     238 LVQDPHQDFNWKIKWSELRITQA 260
BAH70644     279 LREDPQAENTWKILNTNFMMKSM 301
2_pfamImport 247 LIKDPLSESNWKIKGSKLALRSQ 269
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