3R0I,1R0K


Conserved Protein Domain Family
Dxr

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COG0743: Dxr 
1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid transport and metabolism]
1-deoxy-D-xylulose 5-phosphate reductoisomerase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Statistics
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PSSM-Id: 440506
Aligned: 742 rows
Threshold Bit Score: 424.038
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3R0I_A        13 M-K---QLTILGSTGSIGCSTLDVVRH--NPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEASAK-LLKTMLQqqg 85 
WP_015868280   1 M-K---KIAIVGSTGSIGTQTLEVIRK--L-DNFRVVAMACGHNFSLFERQLHEFSPEYAAMLEPNR---ELEVNFP--- 67 
WP_013048270   1 MsKnpcHIALIGATGSVGSSVLDICRA--FPEKFKIIFLVAHRNALKMNDLIHEFHPIGAALTDREAAS-ILRTLQS--- 74 
WP_013255431   3 T-K---KVMLLGATGSIGSATLDILRS--HPDLYTLVAASAHSSEAALEAVVREFGPKAATLSGPVRNL-DLSESFP--- 72 
WP_006486768   2 K-K---RLAILGSTGSIGSQTLQIANR--I-ENIEIVAISCGHNLSLFSKQLSEFHPPFAASLKKSD---SLTDSFP--- 68 
WP_013908863   1 M-K---NLVIFGATGSIGKATIKYIKN--QPHRFRIIGLTAKSKIEELQKLSETFKVPYIVVEREEDAK-FLNSSLS--- 70 
WP_014163200   1 M-Y---KIALIGATGSVGNAILRVIDA--YPDVFSLHSAAAYSNGEKLIRICKKFGTPKAYLFSPQMGSfKKNDDIP--- 71 
WP_014806643   3 K-K---RLAVVGATGSIGRSTLDICRR--FPEAFEVRALAVRSNLKGLKALEGEFKPKFVVIYEEAAAR-DYVPLFD--- 72 
WP_045088086   1 M-K---TLFIAGISGSIGEQALEVLNTewFKENVKLIGGSVYSNWNKLKIDIDKYKLKAVAIVNAQQ---NLPNDYN--- 70 
WP_068513700   1 M-K---GLVIFGSTGSIGTSALSLLTE--FKENFKILGLSGRSNLKKLKIQAETYQVPYLVVENKASAD-WLKANLS--- 70 
3R0I_A        86 SRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDAVKQSKAQLLPVDSEH 165
WP_015868280  68 -SVKFFYGAEGIEEMLEIAKPDYTVLAASGAIGLRYSLKAIEHSKRLCLANKESIVCGGKLLLEKAKRYSAEIIPVDSEH 146
WP_013048270  75 -EVSVYETDDDLEYIVTHPEIDHVVFASSGTAAIKALQKALLADKNVSLANKESIVVAAPWVMPLVRRTD-QLRPLDSEH 152
WP_013255431  73 -TLRFYQGREGLFKMIEEVDADIVVNGIAGAAGLEPSWRAIRSGKDLALANKETIVTSGPLIRHEAKKLQRKILPVDSEH 151
WP_006486768  69 -ATLFFHGEEGIERMLEESKPDYVLLAVSGAAGLRFSLKAIEVCHRLCLANKESIVCGGDLLLKECARKGVELIPVDSEH 147
WP_013908863  71 YKAKVLWGDEGLKELASLDSVDTVVIGISGIKALIPTYYALKSGKRVAIANKECIISVGNLLKEVAQENKAELIPVDSEH 150
WP_014163200  72 -DITVRFGPESLEEMVCDPEVDKVVFASSGVTSLKAIILALDNEKEVLIANKECLIVGGKWIKEHVKY-DNQLLPLDSEH 149
WP_014806643  73 -GTRVLKGKEGLKLLVQ-EDLDHIVFASSGTDAIPALMTALARKMEVSLANKESLVVGGPWVMETVDSFD-QLRPIDSEH 149
WP_045088086  71 -DCKIFQGEDSVEKAIQYCDSDISLIATSGFSGLKHTISAINFSERICLANKESIVCGGNYVLNLAKKFKKLIIPVDSEH 149
WP_068513700  71 YKAEILIGDEGLKELAECSDAEIFLIAISGIKALIPVYYALKKGKRVALANKEAIISAGSFLRETAKAFGGEIIPVDSEH 150
3R0I_A       166 NAIFQSLPQPiqhnlgyadlEQNGVVSILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYI 245
WP_015868280 147 SALFQLLRGD------------VRPEKIFITASGGALRDYPLDRINEVTLKDVLNHPVWSMGVRITVDSATMVNKGLEII 214
WP_013048270 153 NAIWQCLQGE----------DKETVEEIYLTASGGPFRTYDQKALRHVTPEMALAHPVWDMGYKVSIDSATLMNKGIEII 222
WP_013255431 152 SAIFHLLEHQ----------KPEFVEELVITASGGPFLHRPLKTFSSIRPEEALKHPTWNMGGKITIDSATMANKGLEFI 221
WP_006486768 148 SGLFQLLDGS------------RRPKRIIITASGGALRDWPLERIQDATIRDVLRHPVWSMGNRITIDSASMVNKGLEVI 215
WP_013908863 151 SAFFQLLQKE----------KKTYVEKLILTASGGPFYKTPLKDFCKITPEKAISHPVWKMGKKISVDSATLMNKGFEVL 220
WP_014163200 150 NAIWQCLGKSc---------KPFGVKRMFITASGGPFLNYPLDALPRVTPKDALKHPVWQMGSKITIDSATMMNKGLEVI 220
WP_014806643 150 SAIWQCLLGE----------RREDIEEIALTASGGPFLHATYEEMKNATPEIALKHPTWRMGAKITIDSATLFNKGLEII 219
WP_045088086 150 SAIYQLLLGEv-----------TIPEKIILTASGGSVRDIPIDSLENVTPKEVLNHPVWSMGARITVDSATMVNKGLEVF 218
WP_068513700 151 SALFQLLRCE----------ERRFVKTLILTASGGPFLNWDIKDFIKITPELALKHPTWKMGAKITIDSATLMNKGFEVL 220
3R0I_A       246 EARWLFNASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSG--VK---PLDFCKLSALTFA 320
WP_015868280 215 EAHYLFSYDEKDILTYVCKNSAIHAGVIYSDGTIKLHIGKPDMRIPIAYSLTYPQRAALK---Df--TASPLDY-SLSLE 288
WP_013048270 223 EAMYLFDLEHTQVKAVICPGSIVHGIVRFTDGTLKMAASTPDMRLAAATALSYPGRLRLSa-LPqimPLSVHSL-TVQFY 300
WP_013255431 222 EAHYLFDVDPDHIKVVIHPQSMVHSLIRTTDGSLFAQISRPDMRIPIQNALSYPQLISCP--FG---RLELAGT-SFSFH 295
WP_006486768 216 EAKYLFEFETNEIDTYICRNSFIHAGILYSDGVLKLHTGIPDMRIPIAYSLTYPERIQT---IP---EQSIVDV-PMILE 288
WP_013908863 221 EAMVLFDFPLDKIEVVIHPQGLVHGIVKLIDGCYLMHVSPADMKIAIAYALNYPERTEVP--VE---NLDLTKA-KLIFK 294
WP_014163200 221 EASILFDIPIDRIEGIIHPESKIHGGVEFVDGSMQLAVFNPDMFLPALSALSYPQRLDVP--VE---ESP-LGFGTLTLE 294
WP_014806643 220 EACYLFSMPLDRVKAVVQPDSLIHGCVRFCDGSSKLLLSKPDMRIPISFALSYPRRLRLDeaFH---RPQ-ITEWKVNFL 295
WP_045088086 219 EAYHLFG--VKNIDVLINRDSHVHSIVQFSDGVFKMHFGLPNMKVPIAFSISYPERKFN---FN---KPL-LSNTKIEFQ 289
WP_068513700 221 EAIELFSFPPSCIKVIIHPQSIVHSFIEMSDGSLLAHLSQPDMKIPIAYALSYPERWEIP--FS---KINLAELKELTFR 295
3R0I_A       321 APDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALNLSVLEKMDM-R-------EP--QCVDDV 390
WP_015868280 289 EIDYRRYPALKLAREIIGI-PSKQIAFNAADEIAVKNFVEGRISFGSIYRIIEKTIERIEP-I-------SP--KDFEEV 357
WP_013048270 301 PPDEKLFPCLALAKEAARKKGPYPSLLVGADEVAVDAFLRREISFTQISLVIEQVLSSYND-N-------AP--QTLEES 370
WP_013255431 296 EPQEKRYPLLFIAIDALKAGGAYPIAYNAADELAVQAFVEHQIGYCAISEVVRQLLERDWS-S-------SP--VSLEEV 365
WP_006486768 289 ELPKERFPALTLAREICGV-VSKQIAYNAADEVAVEAFMNGRMPFGGIYNIIEKTVERTAD-Q-------NP--VDYSQI 357
WP_013908863 295 KPSFKKFPCLKLAYEVGKLGGAYPLILEAADEVVVSAFLSYKISFDKIPYFLEKTLNEFKI-P-------SInfKNIYEV 366
WP_014163200 295 RIDPKRFPCYFIALEAARKGEACRAILVGADEEAVNLFIEGKISFGQIPELIEKALDSYSG-G-------EP--KSLDDA 364
WP_014806643 296 KIDEEKFPCYGLARRALQMGNAYPPILVGADEAAVEAFLGGVISMVDIFPLLERTLLSYNGpS-------NL--NSLEEA 366
WP_045088086 290 KVDYNRYPSLQLAFNILGN-PILQNAFNAADEVAVESFLSGGIKFTDIYYIIYKTINKIQQ-EfsnstgrEF--ISLEEI 365
WP_068513700 296 EVDFKRFPCLSLAFDVAERGFPYPLILEAADEEVVSAFLEKKISFPQIPCLLEKTLNEFKF-Tf-----gQA--RVLEDY 367
3R0I_A       391 LSVDANAREVARKEVMRL----A 409
WP_015868280 358 QAIDVLARKIAQEEVRKcsr--- 377
WP_013048270 371 LIILERGRERARALIRSAgrcgK 393
WP_013255431 366 LETDQQARTITREILKDF----G 384
WP_006486768 358 IETDSVARKLAQEEVDRcy---- 376
WP_013908863 367 LELHKRVCEFTENLIEGVnr--- 386
WP_014163200 365 SDLVNVGKKLVKKQVK------- 380
WP_014806643 367 IALVDFGRREAGRLSR-Lf---S 385
WP_045088086 366 LEVDKISRTIAKQFILQSr---- 384
WP_068513700 368 LNLHKEVLAFTKEIIKREglcs- 389
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