2W45


Conserved Protein Domain Family
Viral_alk_exo

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pfam01771: Viral_alk_exo 
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Viral alkaline exonuclease
This family includes various alkaline exonucleases from members of the Herpesviridae and Baculoviridae. Alkaline exonuclease appears to have an important role in the replication of herpes simplex virus.
Statistics
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PSSM-Id: 396366
Aligned: 9 rows
Threshold Bit Score: 498.045
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2W45_B   9 DPMEEMTSYTFAR-FLRSPETEAFVRNL----DRPPQMPAMRFVYLYCLCK------QIQEFSGETG------------- 64  Epstein-Barr virus
Q01013  20 DQQTQLCSSSFSH-FLKHPKVQHFISTY----SELVKMPTIRYVYFYYLFK------KIGGFIGNEK------------- 75  Herpesvirus saimiri (...
Q2HR95  27 dQQAVLASLSFSK-FLKHAKVRDWCAQA----KIQPSMPALRMAYNYFLFS------KVGEFIGSED------------- 82  Human herpesvirus 8 s...
Q66641  20 ETKCKLEEFTFSN-FLKARRVREFLR-A----HAVAKLPAMRYVYVYYLFS------RIGDYIGDDT------------- 74  Equid herpesvirus typ...
P09253  29 FVKTDINTINVEHhFIDTLQKTSPNMDCr--gMTAGIFIRLSHMYKILTTLe-----SPNDVTYTTPg------------ 89  Human herpesvirus 3 s...
P24447   9 TLSSVAEEEPLTM-FLLDKLYAIREK------IKQVPFSIVRLCHVYCMLI------KYNASNNNCI------------- 62  Human herpesvirus 6 (...
F5HF49  17 rLLAVWDDEPLSL-FLMNTFLLHQEG------FRNLPFTVLRLSYAYRIFAkm--lrAHGTPVAEDFmt----------- 76  Human herpesvirus 5 s...
P04294  34 PKRPRPNSLPLTTtFRPLPPPPQTTSAVdpssHSPVNPPRDQHATDTADEKpraaspALSDASGPPTpdiplspggthar 113 Human alphaherpesviru...
O36386  20 EQVKKLATYTFSN-FIRCPEVQQAIASG----EIRNDMPHLRFVYIFYLFK------KIQDFIGDTE------------- 75  Alcelaphine herpesvir...
2W45_B  65 ---------------FCDFVSSLVQENDSKD-----------------------------GPSLKSIYWGl--------- 91  Epstein-Barr virus
Q01013  76 ---------------IGTYFSKNVCNNIAAKg----------------------------VPKLADVYKAc--------- 103 Herpesvirus saimiri (...
Q2HR95  83 ---------------VCNFFVDRVFGGVR-------------------------------LLDVASVYAAc--------- 107 Human herpesvirus 8 s...
Q66641  75 ---------------VLAIFGEFMGVSDAGKargegdgesdvhgegeeegdgggeaepgvGPDIPEVYRVc--------- 130 Equid herpesvirus typ...
P09253  90 --------------sTNALFFKTSTQPQEPR-----------------------------PEELAS-------------- 112 Human herpesvirus 3 s...
P24447  63 ---------------LGRKLIEEMQQFLCGTrvdgse------------------dismdLSELCKLYDYcpll------ 103 Human herpesvirus 6 (...
F5HF49  77 --------------rVAALARDEGLRDILGQrhaaea------------------sraeiAEALERVAERcddrhggsd- 123 Human herpesvirus 5 s...
P04294 114 dpdadpdspdldsmwSASVIPNALPSHILAEtferhlrgllrgvr-aplaigplwarldyLCSLAVVLEEagmvdrglgr 192 Human alphaherpesviru...
O36386  76 ---------------VFGIYEKVMGVERAN------------------------------SAKLVDVVQAc--------- 101 Alcelaphine herpesvir...
2W45_B  92 -----------QEATDEQRTVLCSYVESMTRGQSENLMWDILRNGIISSSKLLSTIK---NGPTKVFEPAPISTNHYFGG 157 Epstein-Barr virus
Q01013 104 -----------EKMNLRQQSEICLLIEEVTRGQYLNSLWDALRDGTISSSKFYWATKk-qNSTKKIFEPWPIKNDYYVAG 171 Herpesvirus saimiri (...
Q2HR95 108 -----------SQMNAHQRHHICCLVERATSSQSLNPVWDALRDGIISSSKFHWAVKq-qNTSKKIFSPWPITNNHFVAG 175 Human herpesvirus 8 s...
Q66641 131 -----------ECLPVRTKCRISLAIEAITRGQYENNLWEIFRDGIISSSKFYHAVRq-qNSSKKLFQPWPIVNNYYPLS 198 Equid herpesvirus typ...
P09253 113 ------------KLTQDDIKRILLTIESETRGQGDNAIWTLLRRNLITASTLKWSVSg-pVIPPQWFYHHNTTDTYGDAA 179 Human herpesvirus 3 s...
P24447 104 -------csalCRAPCVSVNKLFKIVERETRGQSENPLWHALRKYTVTATKLYDIY-----TT-RCFLE--YKGQQFFGE 168 Human herpesvirus 6 (...
F5HF49 124 --dyvwlsrllDLAPNYRQVELFQLLEKESRGQSRNSVWHLLRMDTVSATKFYEAFVsgcLPGAAAADGSGGGGSHYTGS 201 Human herpesvirus 5 s...
P04294 193 hlwrltrrgppAAADAVAPRPLMGFYEAATQNQADCQLWALLRRGLTTASTLRWGPQg-pCFSPQWLKHNASLRPDVQSS 271 Human alphaherpesviru...
O36386 102 -----------TEMRPHIQAQICEHIERLTRGQGENVLWEVLRDGVISSSKLLKFVKq-qTPDSKIFNPIPIQKNHYVAS 169 Alcelaphine herpesvir...
2W45_B 158 ------PVAFGLRCEDTVKDIVCKLICg------DA-----------------------------SANRQFGFMISPTDG 196 Epstein-Barr virus
Q01013 172 ------PLAFGLRCEEVIKTVLNELICt------PKq----------------------------ASCFDCGFMQSPLDG 211 Herpesvirus saimiri (...
Q2HR95 176 ------PLAFGLRCEEVVKTLLATLLH-------PDe----------------------------ANCLDYGFMQSPQNG 214 Human herpesvirus 8 s...
Q66641 199 ------PLAFGLRCEDAVKTLLAEFVC-------GRk----------------------------EVMCDVGFLQSPKDG 237 Equid herpesvirus typ...
P09253 180 ------AMAFGKTNEPAARAIVEALFIdpadirtPDhltpeattkffnfdmlntkspsllvgtprIGTYECGLLIDVRTG 253 Human herpesvirus 3 s...
P24447 169 ------AVIYGAKHERVIRHLVATFYVk------R------------------------------EVKETLGLLLDPSSG 206 Human herpesvirus 6 (...
F5HF49 202 ragvspGIQFGIKHEGLVKTLVECYVMh-----gRE-----------------------------PVRDGLGLLIDPTSG 247 Human herpesvirus 5 s...
P04294 272 ------AVMFGRVNEPTARSLLFRYCVgr----aDDggeagadtrrf--------ifhepsdlaeENVHTCGVLMDGHTG 333 Human alphaherpesviru...
O36386 170 ------PVAFGVRNETVVKKLISELVVe------EGi----------------------------GCVTEFGFMLSPNDG 209 Alcelaphine herpesvir...
2W45_B 197 IFGVSLDLCVN----VESQGDFILfTDRSCIYEIKCRFKYLFSKSE-FDPIYPSYTALYKRPCKRSFIRFINSIARPTVE 271 Epstein-Barr virus
Q01013 212 IFGVSLDYCTNv---ETNKDNLLVfHPDTEVYEIKSRFKYLFDKSE-CDTLYKKYKELYSNPCVKTLIKFIFSVSKPAIE 287 Herpesvirus saimiri (...
Q2HR95 215 IFGVSLDFAANv---KTDTEGRLQfDPNCKVYEIKCRFKYTFAKME-CDPIYAAYQRLYEAPGKLALKDFFYSISKPAVE 290 Human herpesvirus 8 s...
Q66641 238 IFGVSLDMCANv---SVGRDNLLEfRADAEIYEIKCRFKYNYSKIE-CDPLYQKYVSLYNSPSKTTLIRFLSGINRPAVE 313 Equid herpesvirus typ...
P09253 254 LIGASLDVLVCdrdpLTGTLNPHPaETDISFFEIKCRAKYLFDPDDkNNPLGRTYTTLINRPTMANLRDFLYTIKNPCVS 333 Human herpesvirus 3 s...
P24447 207 VFGASLDACFGi---SFNEDGFLMvKEKALIFEIKFKYKYLRDKE---DHFVS---ELLKNPTEKSFSDFILSHPVPVIE 277 Human herpesvirus 6 (...
F5HF49 248 LLGASMDLCFGv--lKQGSGRTLLvEPCARVYEIKCRYKYLRKKE---DPFVQ---NVLRRHDAAAVASLLQSHPVPGVE 319 Human herpesvirus 5 s...
P04294 334 MVGASLDILVCpr-dIHGYLAPVP-KTPLAFYEVKCRAKYAFDPMDpSDPTASAYEDLMAHRSPEAFRAFIRSIPKPSVR 411 Human alphaherpesviru...
O36386 210 IFGVSLDMCTNa---SMSDHNTVEfTSTTTIYEIKCRYKYLFSKCD-YDPIYQAYQKLYNSPGRQELIDFIQSIQKPTVE 285 Alcelaphine herpesvir...
2W45_B 272 YVPDGRLPSEGDYLLTQDEAWNlk-dVRKRKLGPGHDL---VADSLAANRGVESMLYVMT------DPSENAGRIGI--- 338 Epstein-Barr virus
Q01013 288 FVPSGRLPSESDYLLAYDEEWNlr-pTKKRKLNASHEM---IKKCIEYNSYAGSQIYILS------DPAENNGQITV--- 354 Herpesvirus saimiri (...
Q2HR95 291 YVGLGKLPSESDYLVAYDQEWEac-pRKKRKLTPLHNL---IRECILHNSTTESDVYVLT------DPQDTRGQISI--- 357 Human herpesvirus 8 s...
Q66641 314 YVPPGKLPTKNDFLLTSDRDWDls-pKRKRNLTPAHKS---LYDCLRANEHASSQVLILS------DPSETEGKIDI--- 380 Equid herpesvirus typ...
P09253 334 FFGPSANPSTREALITDHVEWK------RLGFKGGRALtelDAHHLGLNRTISSRVWVFN------DPDIQKGTITTiaw 401 Human herpesvirus 3 s...
P24447 278 FRERGKIPSSREYLMTYDFQYRpq-rKLRTCPTPAILAp-hIKQLLCLNETQKSTVIVFDck---sDLCEQKLSVFQ--- 349 Human herpesvirus 6 (...
F5HF49 320 FRGERETPSAREFLLSHDAALFratlKRARPLKPPEPLreyLADLLYLNKAECSEVIVFDakhlndDNSDGDATITInas 399 Human herpesvirus 5 s...
P04294 412 YFAPGRVPGPEEALVTQDQAWS----EAHASGEKRRCSa-aDRALVELNSGVVSEVLLFG------APDLGRHTISPvsw 480 Human alphaherpesviru...
O36386 286 YVSRGRLPTQNDYLLSFDRSWDfgppKRKRKLTSGHKI---TEQCMKYNCYTESKVIILT------DPALTSGKIEV--- 353 Alcelaphine herpesvir...
2W45_B 339 ----------------------------------------------KDRVPVNIFINPRHNYFYQVLLQYKIV-GDYVRH 371 Epstein-Barr virus
Q01013 355 ----------------------------------------------KSKFKAGIFMNPRHTYFYQVALQHRVV-QSYIGL 387 Herpesvirus saimiri (...
Q2HR95 358 ----------------------------------------------KARFKANLFVNVRHSYFYQVLLQSSIV-EEYIGL 390 Human herpesvirus 8 s...
Q66641 381 ----------------------------------------------KARFDVDVFINPEHSYFYQILLQYKVV-KNYIQY 413 Equid herpesvirus typ...
P09253 402 -------------------------------------------atgDTALQIPVFANPRHANFKQIAVQTYVLsGYFPAL 438 Human herpesvirus 3 s...
P24447 350 ----------------------------------------------KAVFTVNVFVNPKHRYFFQSLLQQYVMtQFYIND 383 Human herpesvirus 6 (...
F5HF49 400 lglaagdaagggadhhlrgspgdspppipfedentpellgrlnvyeVARFSLPAFVNPRHQYYFQMLIQQYVLsQYYIKK 479 Human herpesvirus 5 s...
P04294 481 -------------------------------------------ssgDLVRREPVFANPRHPNFKQILVQGYVLdSHFPDC 517 Human alphaherpesviru...
O36386 354 ----------------------------------------------KGSFFVDIYINPRHAYYHQCMLQYKIV-TNYVQL 386 Alcelaphine herpesvir...
2W45_B 372 SGGGkp-gRDCSPRVNIVTAFFRK---RSPLDPATCTLGSDl--LLDASVEIPVAVLVTPVVLPDS-VIRKTLSTAAGSW 444 Epstein-Barr virus
Q01013 388 SESPk---SLGTQKNFIVSSFFRK---RHFSDPPVCYVGKK---QLEKTVEIPVFIIITPVYIPRS-ALLETISQAVNFW 457 Herpesvirus saimiri (...
Q2HR95 391 DSGIp---RLGSPKYYIATGFFRK---RGYQDPVNCTIGGD---ALDPHVEIPTLLIVTPVYFPRG-AKHRLLHQAANFW 460 Human herpesvirus 8 s...
Q66641 414 HSSP----GLGSLKTFIVSGFFRK---RNHSDPLECSIGGRg--TLDSACEIPVLLILTPVYIPHC-VVTESLKKASQYW 483 Equid herpesvirus typ...
P09253 439 KLRP----FLVTFIGRVRRPHEVGvplRVDTQAAAIYEYNWp--TIPPHCAVPVIAVLTPIEVDVPrVTQILKDTGNNAI 512 Human herpesvirus 3 s...
P24447 384 HNNPeyieSTEVPSVHIVTAFFRR---R-TEEERSLHLVIDe--TEYIEEEIPLALIVTPVAPNPE-FTCCVITDICNLW 456 Human herpesvirus 6 (...
F5HF49 480 HPDPeridFRDLPTVYLVSAIFRE---R-EESELGCELLAGg--RVFHCDHIPLLLIVTPVVFDPQ-FTRHAVSTVLDRW 552 Human herpesvirus 5 s...
P04294 518 PPHP----HLVTFIGRHRTSAEEGvtfRLEDGAGALGAAGPskaSILPNQAVPIALIITPVRIDPE-IYKAIQRSSRLAF 592 Human alphaherpesviru...
O36386 387 TKGDs--cKHTHPGVFLVSAFFRK---RNSADFPKTYIKTEr-sFVDASVEIPVLLIITPVFVPHG-PLVDTLEQAIKFW 459 Alcelaphine herpesvir...
2W45_B 445 K-AYADNTFDTA-PWVPSGL 462 Epstein-Barr virus
Q01013 458 E-ESAKEAFTEY-PWAPCAL 475 Herpesvirus saimiri (strain 11)
Q2HR95 461 S-RSAKDTFPYI-KWDFSyl 478 Human herpesvirus 8 strain GK18
Q66641 484 N-QSAEEEFSHP-PWVSSSL 501 Equid herpesvirus type 2 strain 86/87
P09253 513 TsALRSLRWDNLhPAVEEES 532 Human herpesvirus 3 strain Dumas
P24447 457 E-NNICKQTSLQ-VWAQSAV 474 Human herpesvirus 6 (strain Uganda-1102)
F5HF49 553 S-RDLSRKTNLP-IWVPNSA 570 Human herpesvirus 5 strain Merlin
P04294 593 D-DTLAELWASRsPGPGPAA 611 Human alphaherpesvirus 1 strain 17
O36386 460 Q-VAVKEEFNHW-PWAPTSL 477 Alcelaphine herpesvirus 1 strain C500
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