Conserved Protein Domain Family
mutL

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PRK00095: mutL 
DNA mismatch repair endonuclease MutL
Statistics
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PSSM-Id: 234630
Aligned: 563 rows
Threshold Bit Score: 495.891
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
54310432    1 MPIQILPARLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIDRGGSRTIRIRDNGKGIAKDELGLALSRHATSKI 80 
222056190   3 TRIKILPEQLTNKIAAGEVVERPASVVKELVENALDAGCSEVMVEIEAGGKRLIRVSDTGCGMTREDALLALERHATSKI 82 
253701877   3 TKIRILPENLTNKIAAGEVVERPASVAKELVENALDAGSKEVVVEIESGGRRLIKVSDTGCGMSRDDALLALERHATSKI 82 
78223260   31 TQIRILPENLTNKIAAGEVVERPASVVKELVENSLDAGCRDIIVEIEAGGRRLIRVTDDGSGMSREDALLSLERHATSKI 110
39997099    3 HRIRILPEILTNKIAAGEVVERPASVVKELVENALDAGCGEIIVEIEGGGRRLIRITDDGCGMSREDALMALERHATSKI 82 
197117368   3 TKIRILPENLTNKIAAGEVVERPASVAKELVENALDAGSKEVVVEIESGGRRLIKVSDTGCGMSRDDALLALERHATSKI 82 
148263827   3 TRIKILPENLTNKIAAGEVVERPASVVKELVENALDAGCSEVVVEIEAGGRRLIKVTDSGCGMTREDALLALERHATSKI 82 
153004950   2 PRIQVLPPGLVNQIAAGEVVERPASVVKELVENALDAGATSVSIDVEEGGLALVRVADDGCGMSADDAQLALERHATSKL 81 
197122538   2 PRIHVLPPGLVNQIAAGEVVERPASIVKELVENALDAGATSVGVDVEEGGLALVRVADDGSGMDRDDALLALERHATSKL 81 
220917323   2 PRIHVLPPGLVNQIAAGEVVERPASIVKELVENALDAGATSVGVDVEEGGLALVRVADDGSGMDRDDALLALERHATSKL 81 
54310432   81 SSLdDLEAIVSLGFRGEALASISSVSRLTLTSRTATQEEAWSA-YAEGrdMDVQLKPAAHPIGTTIEVLDLFFNTPARRK 159
222056190  83 ANDeDLFSLATLGFRGEALPSVASVSRFTLATREKGSLEGTEIyAEGG--RIKEVKACGMAEGTVISVRNLFFNTPARLK 160
253701877  83 ATDeDLFSLCTLGFRGEALPSVASVSRLTISTRTSDSVEGTEIyAEGG--RIKEVKECGMAVGTVISVRNLFFNTPARLK 160
78223260  111 ASDdDLFSLCTLGFRGEALPSIASVSRFSLATRQRGAIEGTEIyAEGG--RIKEVKACGMAEGTVITVRNLFFNTPARLK 188
39997099   83 ATDdDLFSLATLGFRGEALPSVASVSRFTLATRERGSIEGTEIyAEGG--KIREVKACGMAEGTVVSVRNLFFNTPARLK 160
197117368  83 ATDeDLFSLCTLGFRGEALPSVASVSRLTISTRTSDSVEGTEIyAEGG--RIKEVKECGMAVGTVISVRNLFFNTPARLK 160
148263827  83 ASDsDLFGLATLGFRGEALPSIASVSRFALATREKGAIEGTEIyAEGG--RVKEVKVCGMAEGTVISVRNLFFNTPARLK 160
153004950  82 RDAeGLAAIATMGFRGEALPAIASVARFRLDTAPAEDGAGTRVeVEGG--GRPSSGPVARPRGTTIEVRDLFFNTPARRK 159
197122538  82 RDAeGLAAIGTMGFRGEAVPAIASVSRFRLDTSAGEDGAGTRVeIEGG--VLGEVAPVARPRGTTVEVRDLFFNTPARRK 159
220917323  82 RDAeGLAAIGTMGFRGEAVPAIASVSRFRLDTSAGEDGAGTRVeIEGG--VLGEVAPVARPRGTTVEVRDLFFNTPARRK 159
54310432  160 FLRTEKTEFNHIDELLKRIALSRFDVSITLRHNGKTIRQYRASqtqIQKERRLVSACGQSFLQHALAVELEHGDLNLSGW 239
222056190 161 FMKSSETEAGHVGDLLTRLAISRPDIRFIYTNDGKTVFRALN----ADLRERVATLLGRTLSQDLYPLDFCDGQLNVTGL 236
253701877 161 FMKSAETEGGHVGELLTRLAISRPEVRFTYKNDGKVMFRALD----ADLKERVATMLGRSISSFLYPVSYQEGGLKVSGL 236
78223260  189 FMKSAETEAGHVGDLLTRLAISRPEVRFTYVNDGKTVFRALN----GTMEERVAALLGRTIAGALYPLDSTVEGVTVRGL 264
39997099  161 FMKSVETEGGHVADLVTRLALSRPEVRFTCVSDGKTLFRALD----GTLLDRVAALLGKTVASALHPVDLATEGVRVTGL 236
197117368 161 FMKSAETEGGHVGELLTRLAISRPEVRFTYKNDGKVVFRALD----ADLKERVATMLGRSIASFLYPVSYQEGGLKVSGL 236
148263827 161 FMKSSDTEAGHVGDLLTKLAISRPDVRFIYNNDGRTIFRALD----ADLRERVATLLGRALSADLYPLDFHDGPLGVTGL 236
153004950 160 FMRAAATESGHVTEAVVRLALARPDVGFTLRSAGRLVLGSRAG---AAAADRAAQALGRDAHRHLVPVDAGRGNVRVRGL 236
197122538 160 FMRAASTEAGHVSEAVIRLALARPDVGFTLRSGGRLVLGARAG---GGLADRAGQALGREAHRHLLPVDARRGEVRVHGL 236
220917323 160 FMRAASTEAGHVSEAVIRLALARPDVGFTLRSAGRLVLGARAG---GGLADRAGQALGREAHRHLLPVDARRGEVRVHGL 236
54310432  240 ICTPQGSRSQNDVQYCYVNGRMMKDKLINHAIRQAYEANLASDQYSAYVLFIEVDPHQVDVNVHPAKHEVRFHQARLVHD 319
222056190 237 VGKPECSRSAASHVYTYINGRFIRDKVVQHAVLQAYRNFMERGRYPVVVLFISVPAAEVDVNVHPTKHEVRFREQGRVHD 316
253701877 237 VAAPECSRSAGSHLYTYINGRFIKDKVVQHAILQAYRNFLERGRYPVVAVFIDIAPGEVDVNVHPTKHEVRFREQGRVHD 316
78223260  265 VARPDVSRSAAGHLYTFINGRFIRDRVVQHAVLQAYRNFLERGRYPVVVLFIQVPAGDVDVNVHPTKHEVRFRQQGVVHD 344
39997099  237 VARPDVSRSAASHLYTYINGRFIRDRVVQHAILQAYRNFLERGRYPVVVLFIEVSPGEVDVNVHPTKHEVRFRQQGIVHD 316
197117368 237 VAAPECSRSAGSHLYTYINGRFIKDKVVQHAILQAYRNFLERGRYPVVAVFIEIAPGEVDVNVHPTKHEVRFREQGRVHD 316
148263827 237 IAKPECSRSAASHLYTYINGRFIKDKVVQHAVLQAYRNFMERGRYPVVVLFITVPADEVDVNVHPTKHEVRFREQGRVHD 316
153004950 237 VCSPDHSEATGRALYLFVNGRYVRDRGAAHAVLRAFAGTLPPGRHPAGVLFVELPLDRVDVNVHPQKLEVRFAEAREVYD 316
197122538 237 ICSPDHSEATGRALYLFVNGRYVRDRAAAHAVLRAFAGTLPPGRHPAGVLFVELPLHRVDVNVHPQKLEVRFAEGREVFD 316
220917323 237 ICSPDHSEATGRALYLFVNGRYVRDRAAAHAVLRAFAGTLPPGRHPAGVLFVELPLHRVDVNVHPQKLEVRFAEGREVFD 316
54310432  320 FIYQGIQSALQQGAMDDQqsy---------haPQRASAIAAPYADTASESMESAHSHQIAEAAPALQAIADTPNYPNKAQ 390
222056190 317 AIQEAVESVLRSSPWVKT--------------QPVVQKTQASTSIAAARIAQVRESLTQYRPQKTTQQSFKM-------- 374
253701877 317 AIQKAVESVLKETPWLKRsavaaa--srpaekGGGALRPFSSMEASQAALPVTPQPRPALTPGHPDPPPQAQLQQPLVSE 394
78223260  345 VIQGVIEEALRPTPWLRK----------------------------ESQSTVSSPPPERREPATSSERVAEVRELLVNYR 396
39997099  317 VIQGAVEETLRLTPWIRR-------------------SESPVAAPLAVPRPQQYVQGTGARQVEEVRELLENYRPAVAPH 377
197117368 317 AIQNAVESVLKETPWLKRpavaavsrptekdaAAARAVLEGSQAPLPVTPQPRPALTSEKPVPAPQAQPQQSSISEARVA 396
148263827 317 AIQAALESVLRATPWVRK--------------QAAPQPFASPPPASEASATRVAEVRETLARYSPEKHLQQSFTVP---- 378
153004950 317 ALFHAIAGTLRTAPWLAH----------------GRAGGSAPPGPVALTPPGGAGSDETAAVLAWAREAHAPEGS----- 375
197122538 317 ALFHTVAGALRTAPWLRArpqp------gdgvPVGDGGGPAPVPVAGEEAAEVLAWARAARPPEGSGATLV--------- 381
220917323 317 ALFHTVAGALRTAPWLRArpqp------gdgvPAGNGGGPAPVPVAGEEAAEVLAWARAARPPEGSGATLV--------- 381
54310432  391 PEEWLSSSVASKSasntqhqerndkrvrdyraversdymsdkrisgslspqgksrdesgrssqsnydapqrrnnagyqpe 470
222056190     --------------------------------------------------------------------------------    
253701877 395 SRVAEVRELLVNFqprpqpp------------------------------------------------------------ 414
78223260  397 PS------------------------------------------------------------------------------ 398
39997099  378 RPLF---------------------------------------------------------------------------- 381
197117368 397 EVRELLVDFQPRPqpslrpq------------------------------------------------------------ 416
148263827     --------------------------------------------------------------------------------    
153004950     --------------------------------------------------------------------------------    
197122538     --------------------------------------------------------------------------------    
220917323     --------------------------------------------------------------------------------    
54310432  471 sapskqevaayqrliqtppsipshaSSLGSPAKASTTLTGESRSTAVTRQNVVDTQVGVGLGK-----ALSIVAERYLLV 545
222056190 375 -------------------------STPAVPASFRETSLPDPVPVADAAPAPEVERGYFSGLS-----VIGQFNAAYILC 424
253701877 415 -------------------lrpqyrGSVAPREGSPYAPIAAAPVPASEPQSAAQDSDHVAAGYfsslgVIGQFNASYILC 475
78223260  399 -------------------------PAPSRPFFQPLPAVVPAPDQSAEEPDRPMDRGYFSRLA-----IIGQFHASYILC 448
39997099  382 -------------------------APQPAPQPDREPPLPDSGSRMLDDTAVRRHGGYFSSLA-----VIGQYNASYILC 431
197117368 417 -------------------yqgsvtSKEALPYAPMAAPVPVREPETAAPEPDPAAAGYFSSLG-----VIGQFNASYILC 472
148263827 379 -------------------------PAATFQRQQGAVSLPVAAREDDTASDKTESKGYYCSLS-----VIGQFNAAYILC 428
153004950 376 -------------------------GALVPPPSPVPGASGTFAFAIPDEAGLARPAGYFASLR-----YVGQHARTYLLC 425
197122538 382 -------------------------QPAPGAWATGRLAFPVVPAPGAGPEAGPRPEGYFAGLR-----YVGQHARTYLLC 431
220917323 382 -------------------------QPAPGAWATGRLAFPVAPAPGAGPEAGPRPEGYFAALR-----YVGQHARTYLLC 431
54310432  546 SRHDG-IHVLSLDHAQRLHHKGQLRLAATE-GLKPQPLLIPHSVPVEPDLITCAEQHALLLKQLGINLKAKGKSGLIILS 623
222056190 425 QDGNS-LVIIDQHAAHERVAFERLKTQHAAmGVESQRLLFPETVEFSFKEGAVIREHQTELDRVGFSLEEFGGSTWLLNA 503
253701877 476 QRGTD-LILIDQHAAHERVAFEKLKGQFAGrEVDSQGLLFPETMEFSFRESAVLREHQAELARLGFEFEEFGGNTWLLKG 554
78223260  449 QDGSD-LVIIDQHAAHERVAFERLKAQFAAgGVEGQGLLFPDTLELSHREVAELREHGEELRRIGFDLDEFGGTTWVVKG 527
39997099  432 QDGSD-LVIIDQHAAHERVAFERLKTQFAAgRVEGQGLLFPETVELSHRESAVVREHGGELGRLGFDLEDFGGTTWIVKG 510
197117368 473 QRGTD-LVLIDQHAAHERVAFEKLKGQFAGrEVDSQGLLFPETMEFSFRESAVLREHLAELARLGFEFEEFGGNTWLLKG 551
148263827 429 QDGTD-LVIIDQHAAHERVAFEKLKAQFAAaQVESQRLLFPETIELSFKEGATLREHLAELGRLGFSLEEFGGATWLLNA 507
153004950 426 EAQGGtLVVIDQHASHERLLFQRLREVFRTrKLPVQPFLLPQVVTLPPAVARALEGGLPELARLGFDVEPFGGDSFAVKG 505
197122538 432 EAPGGtLVVIDQHASHERMLFHRLREAFRArRIPVQPFLLPQVVTLPPAAARALEAGLAELGRLGFDAEPFGGEAFAVKG 511
220917323 432 EAPGGtLVVIDQHASHERMLFHRLREAFRArRIPVQPFLLPQVVTLPPAAARALEAGLAELGRLGFDAEPFGGEAFAVKG 511
54310432  624 VCLPLRQQNLQQLIPNLLTYLLSIAEDPDAQgw--dkLWDWLATQCVMPVDTFSLSQAIQLVTELEQLWGSDIEQHNQYL 701
222056190 504 VPHLLSGNDYVKTLRDILEELQSLGRSRSFQdilediLARIACHSVVRGSHCLSQQEIKALFQQMDTTEFSSNCPHGRPV 583
253701877 555 VPQVLSATRYVDTIRDILEELGSLSRSRAFSdiqedlLARIACHSVVRGKRTLSPVEIAALFKQMDETDFSSNCPHGRPV 634
78223260  528 VPRLLAGKDYLRILRDTLEEFQAVGANRSVAdaveeiLTRIACHSVVRGEHPLTTAQIEALFAQMDATDYSTNCPHGRPV 607
39997099  511 IPRLLAGTDYLRLLRDTLEELQSLGASRSIAdavediLTRVACHSVVRGEHPLTTGEIEALFAHMDATDFSTNCPHGRPV 590
197117368 552 VPQVLSATRYVDTIRDILEELGSLSRSRAFSdiqedlLARIACHSVVRGKRTLSQVEITALFKQMDETDFSSNCPHGRPV 631
148263827 508 VPRLLSGTDYLRTLRDILEELQTLGRSRTFAdaleeiLSRIACHSVVRGIHPLNGQEISALFAQMDATEFSSNCPHGRPV 587
153004950 506 APAALAGVDLEALLLDLSAQLELVGSGTAVDealhdlLATMACHAAVRANQEVAPEEARALLDGLDAIDFKARCPHGRPV 585
197122538 512 APAALAGVDLTALLTDLGSQLAEVERGSAVDdafhdlLATMACHAAVRANQDVSPEEARALLDGLDAIDFKARCPHGRPV 591
220917323 512 APAALAGVDLTALLTDLGSQLAEVERGSAVDdafhdlLATMACHAAVRANQDVSPEEARALLDGLDAIDFKARCPHGRPV 591
54310432  702 LRPVDVSTAIEAFLYE 717
222056190 584 LHTLTLAEIERMFKR- 598
253701877 635 MQTLTLAEVEKMFKRI 650
78223260  608 LQRLTLAEVERMFKR- 622
39997099  591 LQRLTLGEVEKMFKRV 606
197117368 632 MQTLTLAEVEKMFKRI 647
148263827 588 LRSLTLPEIERMFKR- 602
153004950 586 VFELPLAELERRVGRR 601
197122538 592 VFELSLADLERRVGRR 607
220917323 592 VFELSLADLERRVGRR 607
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