Conserved Protein Domain Family
RT_G2_intron

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cd01651: RT_G2_intron 
RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable element with both gag-like and pol-like genes. This subfamily of proteins appears to have captured the RT sequences from transposable elements, which lack long terminal repeats (LTRs).
Statistics
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PSSM-Id: 238828
Aligned: 144 rows
Threshold Bit Score: 103.82
Created: 3-May-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activeputativeputative NTP
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based primarily on the structure of the stalled complex of HIV-1 RT bound to NTP and DNA primer-template (1RTD).
  • Citation:PMID 9831551

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
NP_982096   101 KRVFIPKanggqRPLGIp--------tIEDRIIQQMMKQVLEPVLEAQFfk--------------ySFGFRPERTTYHAL 158 Bacillus cereus ...
NP_937600    60 RPLTIQPnekktRQLAIp--------tVADRIIHTAIAQKLVAKFEPEFeh--------------iSYGYRPNRSYTHAI 117 Vibrio vulnificu...
ZP_00766283  78 RRVAIAKasggeRAIAIl--------tIRDRIAQRAVQQVLTPLFEPLFld--------------cSYGSRLAVGVPEAI 135 Chloroflexus aur...
ZP_01425057  75 RRLFLDKrdggkRSIAIl--------aVRDRIAQRAVLQILEPEIEPTFld--------------cSYGFRPYVGVPHAL 132 Herpetosiphon au...
YP_014936    61 KRIEEKNpefdnRPIKTkdrvi-myagHMDNFIYKYYAEVLNKDFYNKFcmekg--------iddcVSAYRNNKVGKSNI 131 Listeria monocyt...
YP_516914    59 NNGISPKt----RELCYs--------aHIDRYIFQYYGYKLNQLYNERVvndgind---sviayrdNLKKSNIHFAKKAI 123 Desulfitobacteri...
YP_695460    60 NKKKDPKg----RNIFYs--------sHVDGYIYQYYGQLVNEYYDKKSielg---------inkvATAYRNNLRGKCNI 118 Clostridium perf...
ZP_01244536  64 RNPSGKRr----RIIGTpkirniyyssHLDSLIFSYYNYLLSENYKELMklknfnnsivayrkiplFEGSEKNKCNIDFA 139 Flavobacterium j...
ZP_01457859  61 EGEIVPKnk--sRPISYa--------aHTDSHIYSYYATLLQPIYEKFIekhglgt---nitgfrkLDGECNIDFAHRAF 127 Desulfovibrio vu...
YP_661311    62 KLIKHKKp----RPIAYa--------aHSDAAIYSYYAQLLSKEYEVKVaelnldd----nvlafrSKGKSNIHFANDAF 125 Pseudoalteromona...
Feature 1                            ######                                                     
NP_982096   159 Ervkvlv---hntgyHWIVEGDIRQFFDKVNHRILIKKLwsmgikdrrilclite------------------------- 210 Bacillus cereus ...
NP_937600   118 Rhieql----rnqgyLYVLDADIKGYFDHICHKRLKQILqkylednwvesimtlll------------------------ 169 Vibrio vulnificu...
ZP_00766283 136 Ervvry----teqglIWVIDGDIRAYFDSIDHGILLGLLrqridepailhliaqwlavgsvhtetpdetlpdsplvallr 211 Chloroflexus aur...
ZP_01425057 133 Triery----rqqglQWVAHADISDCFGTIDHQILLSQLhqrisdravveligqwlsvgvmedaatteasnwwddgedll 208 Herpetosiphon au...
YP_014936   132 DfaaeiinqmvnykeAYILVGDFTNYFDKINHELLKKHLaevlnqprlskdwfnvfrsitkygyyeksflneeyg----- 206 Listeria monocyt...
YP_516914   124 Dfird-------tksCFIVVGDFTNFFDNLDHKYLKKMLkeligglpedyyavfknitrystwdmehilklnglp----- 191 Desulfitobacteri...
YP_695460   119 HfakevfefickcnnAFIYVSDFKGFFDNLDHNYLKEKLeyvlnvsklpidqyviyknitkytyielsdiksvk------ 192 Clostridium perf...
ZP_01244536 140 Kdtfeyie-knkekkLSVIVADVTSFFDNLNHKILKKQWsrllnektlpdchfnvfkaltnlryvesdqlfnsyfgtmiv 218 Flavobacterium j...
ZP_01457859 128 Nairs-------mtpCIALSFDVKSFFDEIDHSILKQAWctilektllpedhfaifkslttysyvdrddafnafg----- 195 Desulfovibrio vu...
YP_661311   126 Eainq-------vgpCTAIGYDVSKFFDTLDHGVLKSQWqtllgvktlpddhykvfksltkftqvdkcklfgslgl---- 194 Pseudoalteromona...
Feature 1                                                                                       
NP_982096       --------------------------------------------------------------------------------     Bacillus cereus ...
NP_937600       --------------------------------------------------------------------------------     Vibrio vulnificu...
ZP_00766283 212 rsgelihealnapsdplptaydypdlsr----------pasphsgiptglfaalslaqpafeiarqltpllkrigaqrla 281 Chloroflexus aur...
ZP_01425057 209 erlakhgedllwpnqgypqagpsyapqmldfeanrtdslrkralqglasnaalwgithskrvisglrslaplfkqvpggs 288 Herpetosiphon au...
YP_014936   207 ----------------------------------------------------------------------sdesikrsnk 216 Listeria monocyt...
YP_516914   192 ----------------------------------------------------------------------nnkkgiqeln 201 Desulfitobacteri...
YP_695460   193 ------------------------------------------------------------------------dkndnkvn 200 Clostridium perf...
ZP_01244536 219 ekgipn------------------------------------------------------sdkkeykrikinsnkyfkek 244 Flavobacterium j...
ZP_01457859 196 ----------------------------------------------------------------------itksskkngi 205 Desulfovibrio vu...
YP_661311   195 ----------------------------------------------------------------------sihnpkvqnk 204 Pseudoalteromona...
Feature 1                                    ##                                                 
NP_982096   211 -----------flkagifkniirndnGTPQGGiLSPLLANVYLHSFDkwvakqfeefttrheyskhdhklrglkssnlkp 279 Bacillus cereus ...
NP_937600   170 ---------sqqmpaqtllfgvelgrGIPQGSpLSPLLANLYLDGFDealld--------------------------rg 214 Vibrio vulnificu...
ZP_00766283 282 vggalavgtvllselvhraqashdrrGTLQGGpLSPLLANIYLHPFDlamta--------------------------hg 335 Chloroflexus aur...
ZP_01425057 289 ltwgaagiatlaliplsqrllrqherGTLQGGaISPMLANIYLDSFDramte--------------------------rg 342 Herpetosiphon au...
YP_014936   217 ksyfeniskfrefqknnktlcnknkfGIPQGSaISAVFANIYASEFDlklkeia----------------------defs 274 Listeria monocyt...
YP_516914   202 qkdlaltlsqfkkykskyqkpntkgyGIPQGSaISAVLSNIYMLYFDnmindyv----------------------kkhn 259 Desulfitobacteri...
YP_695460   201 akakyfntqefrsfkknnlkknkeeyGIPQGAsISSVYSNIYMIDFDkkvndyv----------------------tsnk 258 Clostridium perf...
ZP_01244536 245 navaycsksdflknnlnliisanstkGIPQGSpISATLANVYMMDFDqevydki----------------------vsnk 302 Flavobacterium j...
ZP_01457859 206 rricnplefrsilrpaglikrnknsyGIPQGSpISGLLSNIYLFEFDkaisyfa----------------------sdtk 263 Desulfovibrio vu...
YP_661311   205 rlctaeqfrkyvrennlisknprpnkGIPQGTpISALLSNIYMLDFDqrvkeal----------------------egqg 262 Pseudoalteromona...
Feature 1            # ##                                                                       
NP_982096   280 gyLIRYADDWVLVTNNksh------ayRWKTVIKNFLq---kELKLELSEEKTRItnir------------------hkp 332 Bacillus cereus ...
NP_937600   215 eqIVRYADDFVVLVTHeqq------aqHCLAFVTQYLa----SLKLQLNTEKTRVvsf-------------------qdg 265 Vibrio vulnificu...
ZP_00766283 336 arMVRFVDDFVVMCPDrtt------aeHTLVLVERQLa----TLRLTLNPQKTRIvay-------------------agg 386 Chloroflexus aur...
ZP_01425057 343 hiLVRFADDFVLLGAHqaa------veQALADATNVLk----RLRLATKESKTGVqhf-------------------ndg 393 Herpetosiphon au...
YP_014936   275 giYRRYSDDFILVIPKsdivn-eqkirRIETDTRRVAs----EYKIELHKDKTGLylyendkif-------diisnevsh 342 Listeria monocyt...
YP_516914   260 glYMRYSDDFIIILPEnnks----lfvEQYGFLVKTIn---sVDRLNLQPDKTQVfqydnnqilscneivspgvingkdi 332 Desulfitobacteri...
YP_695460   259 glYRRYCDDLIIIIPIrddeefnneciEYGNKIESIVq---dTPRLELSPEKTEKfiysdckdkk-----ltnlkenkdi 330 Clostridium perf...
ZP_01244536 303 gfYQRYSDDLIIICEQef-------edDIIKFVRDRIq---nLVKLEISESKTKVyrfe------------------eln 354 Flavobacterium j...
ZP_01457859 264 shYYRYCDDIIIICNEeh-------eeLFKNLVSDELk----KLNLRTNEKNVIRkffmgcd-----------gpecdkp 321 Desulfovibrio vu...
YP_661311   263 gvYFRYCDDMLFIIPDaa--------kQFVSSIDQFVtdaieSLKIEINHGKTEKrqfvlkgs----------elfsnkp 324 Pseudoalteromona...
Feature 1          ##   
NP_982096   333 IEFLGFKY 340 Bacillus cereus ATCC 10987
NP_937600   266 FTFLGVSF 273 Vibrio vulnificus YJ016
ZP_00766283 387 IEFLGQAL 394 Chloroflexus aurantiacus J-10-fl
ZP_01425057 394 LTFLGHRF 401 Herpetosiphon aurantiacus ATCC 23779
YP_014936   343 LDYLGFVF 350 Listeria monocytogenes str. 4b F2365
YP_516914   333 LDYLGFSF 340 Desulfitobacterium hafniense Y51
YP_695460   331 INYLGFSF 338 Clostridium perfringens ATCC 13124
ZP_01244536 355 GKFLGFEI 362 Flavobacterium johnsoniae UW101
ZP_01457859 322 IQYLGFVF 329 Desulfovibrio vulgaris subsp. vulgaris DP4
YP_661311   325 LQYLGFLF 332 Pseudoalteromonas atlantica T6c

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