Conserved Protein Domain Family
DUF4422

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pfam14393: DUF4422 
Domain of unknown function (DUF4422)
This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 255 and 371 amino acids in length.
Statistics
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PSSM-Id: 433931
Aligned: 80 rows
Threshold Bit Score: 233.959
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_013405179   10 IINVFHKKYY--QFDNDLYFKIQAGSALS--K-ENLAMYKDNS-----GDNISNKNPYYSELTAQYWFWKNyn--ySNLD 77   Halanaerobium...
wustl:BV3861    7 ILVCAHKDSR--LPQHEYFCPIQVGASLT--S-ARFFPVLDNT-----GDNISDRNPHFCELTAHYWAWKNl-----KCD 71  
WP_013757454   13 ILVCCHKQCElpLNTDNIFLPIHVGAAIN--S-IDLKMQRDDQvngvlCDNISSKNKSFCELTAMYWAWKNikklyPSLE 89   Treponema bre...
WP_004329633    6 ILVCAHKQDA--CLKTPPYQPVQVGRAISq-T-ELPFAVGDDT-----GDNISDRNRHYCELTAHYWAWKNl----HDAD 72   Alistipes put...
WP_118366891   12 IYISCSATND--KPTFPFIYNIYAGAALNnnT-IDSDTLKDNI-----GDNISEKNPYYCELTVHYYAWKN-----TNAD 78   Clostridium s...
WP_015263542    8 IYVSCHKDYY--VPIHPLLYPIQVGAALSp-R-RLEGMLYDDT-----GDSISLKNKSYCELTAQYWVWKNd-----KAD 73   Desulfitobact...
CDD58915        9 IFIACHKPTY--VPENPIFYPVQVGTALTe-KrLEHMAYRDNE-----GDNISGKNPDYCELTAQYWAWKNi-----DCD 75  
CDD55665        6 ILVACHKDTA--LLKSNILLPIQVGAALGk-R-KLDNMLMDNT-----GENISEKNSMYCELTAQYWAWKNl-----NAD 71  
WP_012809197  390 IFITSHKDVD--VPESNYLQPIQVGPGQKt-N-RFSYMLHDDE-----GDNITEKNPMYCEMTTQYWAWKNi----TNER 456  Lancefieldell...
AGI85280      333 IFISCHKDTE--YVKNDIFKPIQVGTALSg---KKLDMLHDDE-----GENISFKNKSYCELTAQYWAWKNc-----SVN 397 
WP_013405179   78 YIGLCHYRRYFAFLNAKnkikknikylkfivkkyflknnltfsyfptlylnydeADKELENF-NDQIIDQLPTFDIFLP- 155  Halanaerobium...
wustl:BV3861   72 IIGLNHYRRFFDFHRPFpafspd-------------------------rsfiniDSFLKETYrFPDLETLLNDYDIILS- 125 
WP_013757454   90 YIGLNHYRRYFAFEKYYglrd-----------------------------iypeTDVLNYIInMKRLTHFLAEGYTIIP- 139  Treponema bre...
WP_004329633   73 YIGLNHYRRYFDFEGGSacslr----------------------------tvrsEAFFSASHpVPDFDRLFSRCDIVMA- 123  Alistipes put...
WP_118366891   79 YLGFFHSRRYISFNRQNlvdksyskrklp--------------kpyivkdfptkELLEKNGYdKENIISLLKIYPIIGV- 143  Clostridium s...
WP_015263542   74 YVGFFHYRRYLCFDERYlvdlntqsshkp-------------vipykifdeptpETLDALKFnVEGLSRLISRYEVIAP- 139  Desulfitobact...
CDD58915       76 YYGFFHYRRYLTFHRVCpvmasgrilgkr--------------qhpyieldsvwDDLTPYWMeAEWMAQQIMKYDLLTV- 140 
CDD55665       72 YYGFFHYRRYLNFSDRRyredrwgn---------------------vrenilseEMKEKYGLsDGKIEALVSSYDLVIS- 129 
WP_012809197  457 YVGFGHYRRYFNFTDTIypenpfge---------------------vmddfideDAIKKYGLdDQTIAQCIEGYDLITTg 515  Lancefieldell...
AGI85280      398 YYGFLHYSRYFNFTETIfpeigynn---------------------invsnitdELIDKFGWtEKQIIECISGYDVVTT- 455 
WP_013405179  156 --YKVI-----FSNFNIEEQYIYS--HI-YQDFEIIKEVLLRKNKNYQESMETVL-NQNK-FLA-YNMFIMRKDIFVEYN 222  Halanaerobium...
wustl:BV3861  126 --PKRH-----YP-YNVATQYAIF--HL-VNDLNLLKEVIQHLTPEYAEAFHTFM-YHCN-AYSgYNMFITGRKHFDEYS 192 
WP_013757454  140 --KRKI------YPYPLQIDYSVC--HV-SEDIRTLRKVIIDLYPEYITSYDHVLlHNNK-LAH-YNMLIMEYSHFDSYS 206  Treponema bre...
WP_004329633  124 --RPKI-----Y-PYNLYTDYCKC--HI-ESDLLTARQVIAEKYPAYLPDFDRVF-FRNNrLSH-FNMFVLPRERFEAYS 190  Alistipes put...
WP_118366891  144 --IPEK-----M-PETTYEHLIRTq-KNgKTEFKLIEEKLKLNYPEFLPAFNEYM-SSRY-LYF-CNMYVMHRDIFDKYC 211  Clostridium s...
WP_015263542  140 --IAEE-----MYV-SIYNHYKDTa-FNfIEDLDLILSIISEKFPNFTESANEYM-NNTK-HYF-CNMFIMKKEIFNSYC 207  Desulfitobact...
CDD58915      141 --YRER-----I-NTTVYRQYCQY--HE-AEELNHMLEIINRIYPEYTDVAKAYM-SSKD-IYY-MNMYIMKKELFHTYM 206 
CDD55665      130 --EEKNvasmpGKASNVYEQYQYGdaLH-IEDLKCVSDIVREKYPDYAEDMELYL-KGKY-TCF-CNMYIMKKELFFEYM 203 
WP_012809197  516 vkDIRKf---pGSANTPLEQYHAAplLH-PKDMDTMAALIVERHPEYAEDVNAFL-NGYE-QCF-CNMYIMRRELFDRYA 588  Lancefieldell...
AGI85280      456 --FSANtq-ivQKKKDVYENYCDAayLH-EKDLLTLTQIIEEKYPKFSKYVEQYL-LGQR-AIF-CNMYILRKDIFNDYC 528 
WP_013405179  223 KWLFNILFEIEKKAKISKY-NYQARLLAFAAERLFNIYIH--KlkqDK 267  Halanaerobium hydrogeniformans
wustl:BV3861  193 QWLFSVLFELEKRVKLSAYpD-QARLFGYLSERLINVYCI--R---HR 234 
WP_013757454  207 DWLFSILFEAEKRIDIHCYnDIQMRIFGYMSERLFCVWLY--H---NK 249  Treponema brennaborense
WP_004329633  191 AWLFDILFEVERRIEIQDd-PVQGRVMGYLSERLLSVWVR--H---NR 232  Alistipes putredinis
WP_118366891  212 SWLFDILEYVDAN-----MpQRIERDDGMMAERLFGVFMT--Yikkeg 252  Clostridium sp. AM09-51
WP_015263542  208 AWLFSILTEFDRIADYSKYsGKASRVDGFLGERLFGIYYTwlKkqphv 255  Desulfitobacterium dichloroeliminans
CDD58915      207 EWLFTLLDTFEQE-RKEINkPQEPRLYGYLAERLFGIFYF--Y---QR 248 
CDD55665      204 EWLFDILFEFEKRANMRDYsIEGRRTPGHLGERLLTLYYM--HlkrTR 249 
WP_012809197  589 AWVFPLVDEWTARTDMSTYsKEALRTPGHLTERLFNIWRM--Hmlrte 634  Lancefieldella parvula
AGI85280      529 TWLFDILDEFVKRTDMSLYtVNEMRTPGHLSERMFGIYLLylQn-eRK 575 
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