1WDJ


Conserved Protein Domain Family
Uma2
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pfam05685: Uma2 
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Putative restriction endonuclease
This entry includes a group of putative nuclease, including hypothetical protein TT1808 (also known as Uma2 or TTHA1514), an AT-rich DNA-binding protein from Thermus thermophilus. This domain has a 3-layer alpha/beta/alpha topology similar to that found in restriction endonucleases. The nuclease domain is ubiquitously found in enzymes involved in metabolism of nucleic acids, mostly in nucleases with diverse biological functions.
Links
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Statistics
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PSSM-Id: 428585
Aligned: 139 rows
Threshold Bit Score: 59.7284
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1WDJ_B  14 EELRRLSElNPGYQWERsPEGRLWV-SPTG-GESGRRSLQLAYQLARWNEErg-lgVVFDS-STGFKFp-DGSILSPDAA 88  Thermus thermophilus
Q8YNG7  14 EEYFIWEe-KQQLRHEY-LNGEVYA-MTGGtQNHGRIASNIIFIVKGHLRGgg--cQVGNS-DCRINIfeTKDYVYPDVS 87  Nostoc sp. PCC 7120
P72821  16 EEYLQWEE-RQREKHEY-FDGQIYAmGGGS-KNHSVISVRLSTLFCNHLDGgd--cEIGNS-DLKIQIvnTQNYTCPDVS 89  Synechocystis sp. PCC...
Q8YZF4  14 EEYFAWEE-QQLEKHEY-INGEVYAmTGGS-INHGRIGIRFTAMFDSHLENtg--cITGNS-DVKLNIfgSNNYTYPDAS 87  Nostoc sp. PCC 7120
Q8YWY2  14 EEYLAWEp-LQDLRYEY-VNGEVFAmTGGT-IPHNDIALNFYRALYPHLRArg--cRVNVS-DVKVQVtpQSPYYYPDVI 87  Nostoc sp. PCC 7120
Q7NKB7  13 QEYFEWEa-LQEYKHEY-VDGEVFEvTGGT-IPHAAVTLNLAFSLKLHLRGgp--cRVFSS-DAKVGVseQGPFLYPDVV 86  Gloeobacter violaceus
Q8YMM1  13 QEYLEWEe-RQDIKYEY-VNGEVFAmTGGT-LPHTTIALNLASALKSHVRGgs--cRAFMS-DAKVAVseGMSFHYPDVV 86  Nostoc sp. PCC 7120
Q7NM95  11 AEYIEWEt-HQQIRHEY-VNGEIFAmTGSS-IAHNTIAVNVARLIGNYLEDsrspcRVFVS-DVKAQIteDGPFYYPDVM 86  Gloeobacter violaceus
Q7NHF6  13 EQFLRWEr-EQPQKYEY-RYGRIFSmAGGS-KSHNLIAVNVTAAVHGHLIDsl--cRVFNSdQKVACSp-AGPFYYPEVS 86  Gloeobacter violaceus
P73844  13 AEYLQREe-QATEKSEF-IQGEIIPiAGAS-ANHNRLTFNLSRLL---PLEigdrqYEIFVsDMRLWIaeSESYFYPDVM 86  Synechocystis sp. PCC...

1WDJ_B  89 FVERGaWEALSEAeregF-PPLAPKAVFEVRSASQDpEELRAKMGIYL-RNGVLLGVLVDPYARAVEVFRPG-----KPP 161 Thermus thermophilus
Q8YNG7  88 VTCDE--RDRTAI----Q-AIQYPCLIVEVLSPSTAsYDRGDKFRLYRrNPSLQDYLLVDAEKIAIDLYRKNergnwEIF 160 Nostoc sp. PCC 7120
P72821  90 VTCDP--RDRKST----Q-FITYPCLVVEVLSPSTEaYDRGGKFRLYAhNPMLQDYLLVSSTSVEIDLYHKNddgdwLIL 162 Synechocystis sp. PCC...
Q8YZF4  88 VTCDD--RDKTTT----R-YITYPCLIVEVLSKTTEaYDRGGKFRMYRqNPALIDYLLVSSTSIEIDLYHKNdagdwLII 160 Nostoc sp. PCC 7120
Q8YWY2  88 VSCDP--QDINAR----R-FIQNPKIIAEVLSPGTSgKDRGEKFTNYLkIPSLQEYLLIDSETISVERYCRGegrmwLYY 160 Nostoc sp. PCC 7120
Q7NKB7  87 VTCDE--RDRNAA----R-AIHFPTLVIEVLSPTTEaYDRGTKFRRYRrIETLSEYVLVDAERVGVDCFRRNpvgiwELH 159 Gloeobacter violaceus
Q8YMM1  87 VSCDE--RDKQAT----K-FLQYPCLIVEVLSPSTEaYDRGAKFKQYRrIQTLKEYVLIDAEKINLDCFRLNengiwELY 159 Nostoc sp. PCC 7120
Q7NM95  87 ATCDE--RDRNAV----Y-TIRHPCLIVEVLSPTTEaFDRGDKFGDYRrIDTLQEYMLFDSRKLAVEHYRREsertwKLV 159 Gloeobacter violaceus
Q7NHF6  87 VSCDD--REEPTG----Y-MLQYPCLIVEVLSKNTAeFDRSVKFRDYGkIETLQEYLLLDSQVVAASLYRRQginlwQVQ 159 Gloeobacter violaceus
P73844  87 VIAEE-PKFTDNS----QmAVTNPSLIAEVLSTSAAgFDKNQKFGFYRtIPKLQEYLLID-----QFCYRVEh---yQKV 153 Synechocystis sp. PCC...

1WDJ_B 162 LRl-eGVERVSLdPELP-GFALS 182 Thermus thermophilus
Q8YNG7 161 NYq--LGDNIKL-QSI--DLSFP 178 Nostoc sp. PCC 7120
P72821 163 NYq--ASDRLEL-KSI--GLSFA 180 Synechocystis sp. PCC 6803 substr. Kazusa
Q8YZF4 161 NYk--PGDTIEL-KSI--NLSFP 178 Nostoc sp. PCC 7120
Q8YWY2 161 PYt--EGDTITL-SSI--EFELA 178 Nostoc sp. PCC 7120
Q7NKB7 160 PYteeDHEIRFAsLDLR----VS 178 Gloeobacter violaceus
Q8YMM1 160 SYe-eGNEVYLQsVDFR----FP 177 Nostoc sp. PCC 7120
Q7NM95 160 LYa--AEDTMHL-ESL--DCELA 177 Gloeobacter violaceus
Q7NHF6 160 LFe--EAEVLHL-DSI--AMELP 177 Gloeobacter violaceus
P73844 154 GD---RQWLLTElMGENaEIEFS 173 Synechocystis sp. PCC 6803 substr. Kazusa
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